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Mar 28, 2024

Groundbreaking study shows how lifestyle changes can reverse biological aging

Posted by in categories: biological, genetics, life extension

In a groundbreaking study led by Dr. Karen Fitzgerald, six women between the ages of 45 and 65 experienced a remarkable reduction in their biological age by an average of five years in just eight weeks. The findings offer promising insights into the potential of lifestyle changes to combat aging.

The study, which focused on the distinction between chronological age and biological age, revealed that while chronological age remains fixed, biological age — the age of one’s cells — can be influenced and even reversed through targeted interventions.

Using Dr. Steven Horvath’s epigenetic clock, which measures 353 markers associated with methylation changes linked to aging, the researchers assessed the participants’ biological age before and after the intervention.

Mar 28, 2024

Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

Posted by in categories: biotech/medical, life extension

Antibody-mediated depletion of myeloid-biased haematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system.

Mar 27, 2024

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

Posted by in categories: biotech/medical, life extension

Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the in vivo effects of senescent cells on intestinal fitness. Here, we identify the accumulation of senescent cells in the aging gut and, by harnessing senolytic CAR T cells to eliminate them, we uncover their detrimental impact on epithelial integrity and overall intestinal homeostasis in natural aging, injury and colitis. Ablation of intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged ISCs. This intervention improves epithelial integrity and mucosal immune function. Overall, these results highlight the ability of senolytic CAR T cells to rejuvenate the intestinal niche and demonstrate the potential of targeted cell therapies to promote tissue regeneration in aging organisms.

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Mar 27, 2024

Multiomic approach boosts disease prediction accuracy beyond traditional methods

Posted by in categories: biotech/medical, genetics, life extension

🧬🔬📊


In a recent study published in the journal Nature Aging, researchers assessed the added predictive value of integrating polygenic risk scores (PRSs) and gut microbiome scores with conventional risk factors for common diseases in a long-term cohort study.

Analysis: Integration of polygenic and gut metagenomic risk prediction for common diseases. Image Credit: remotevfx.com / Shutterstock.

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Mar 26, 2024

Chronic musculoskeletal pain may accelerate brain aging

Posted by in categories: life extension, neuroscience

In a study published in Nature Mental Health, scientists from China and the United States have found that individuals suffering from chronic musculoskeletal pain (CMP) may face a higher high risk of brain aging.

Mar 25, 2024

To Live Past 100, Mangia a Lot Less: Italian Expert’s Ideas on Aging

Posted by in category: life extension

Valter Longo, who wants to live to a healthy 120 or 130, sees the key to longevity in diet — legumes and fish — and faux fasting.

Mar 24, 2024

Taurine Extends Lifespan (In Mice): What’s My Data? (6-Test Analysis)

Posted by in category: life extension

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgartenUse Code: C…

Mar 23, 2024

Newly discovered ‘fountain of youth’ phenomenon may help stars delay death by billions of years

Posted by in category: life extension

Recent observations show that some white dwarf stars suddenly stop cooling. Now, scientists propose a ‘fountian of youth’ mechanism that may explain how these stellar husks avoid death for billions of years.

Mar 23, 2024

Anti-Aging Breakthrough? This FDA-Approved Procedure Reversed Aging in Multiple Clocks In Human Trial

Posted by in categories: biotech/medical, life extension, neuroscience

Plasma exchange human trials.


TPE Treatment, is an FDA-approved treatment for many autoimmune diseases, shows age reversal identified by multiple biological clocks. It improved both physical strength and mental health in human clinical trial(unpublished data) presented by Dr. Kiprov.

Continue reading “Anti-Aging Breakthrough? This FDA-Approved Procedure Reversed Aging in Multiple Clocks In Human Trial” »

Mar 22, 2024

Is Aging a Disease? Epigenetics with David Sinclair & Neil deGrasse Tyson

Posted by in categories: biotech/medical, genetics, life extension

A time question and answer starting at 32:22 (5−6 years)


Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.

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