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The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job of knocking out genes to cure hereditary disease. But it’s still not possible to insert whole genes into the human genome to substitute for defective or deleterious genes.

A new technique that employs a retrotransposon from birds to insert genes into the genome holds more promise for gene therapy, since it inserts genes into a “safe harbor” in the human genome where the insertion won’t disrupt essential genes or lead to cancer.

Retrotransposons, or retroelements, are pieces of DNA that, when transcribed to RNA, code for enzymes that copy RNA back into DNA in the genome—a self-serving cycle that clutters the genome with retrotransposon DNA. About 40% of the human genome is made up of this “selfish” new DNA, though most of the genes are disabled, so-called junk DNA.

Genetic Engineering and DNA alteration is an emerging technology with huge ramifications in the future, including potentially altering the DNA of adult humans, not just embryos or plants \& animals.
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CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond. And with their recent development of CRISPR-COPIES, researchers at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) are further improving CRISPR’s versatility and ease of use.

“CRISPR-COPIES is a tool that can quickly identify appropriate chromosomal integration sites for genetic engineering in any organism,” said Huimin Zhao, CABBI Conversion Theme Leader and Steven L. Miller Chair of Chemical and Biomolecular Engineering (ChBE) at the University of Illinois. “It will accelerate our work in the metabolic engineering of non-model yeasts for cost-effective production of chemicals and biofuels.”

Gene editing has revolutionized scientists’ capabilities in understanding and manipulating genetic information. This form of genetic engineering allows researchers to introduce new traits into an organism, such as resistance to pests or the ability to produce a valuable biochemical.

Find out all about about RNA editing, as two candidates have just managed to reach the clinic for the first time.

In the realm of scientific innovation, the past decade has seen the CRISPR/Cas systems emerge as a groundbreaking tool in genome editing, boasting applications that span from enhancing crop yields to pioneering gene therapy.

The recent advent of CRISPR-COPIES by the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) marks a significant leap forward, refining CRISPR’s flexibility and user-friendliness.

CRISPR-COPIES represents a cutting-edge solution designed to swiftly pinpoint ideal chromosomal sites for genetic modification across any species.

“Aging reversal is something that’s been proven about eight different ways in animals,” geneticist George Church says. So when will humans get to turn back t…

Benjamin Franklin famously wrote: “In this world nothing can be said to be certain, except death and taxes.” While that may still be true, there’s a controversy simmering today about one of the ways doctors declare people to be dead.

Bioethicists, doctors and lawyers are weighing whether to redefine how someone should be declared dead. A change in criteria for brain death could have wide-ranging implications for patients’ care.

With more than 1,000 nerve endings, human skin is the brain’s largest sensory connection to the outside world, providing a wealth of feedback through touch, temperature and pressure. While these complex features make skin a vital organ, they also make it a challenge to replicate.

By utilizing nanoengineered hydrogels that exhibit tunable electronic and thermal biosensing capabilities, researchers at Texas A&M University have developed a 3D-printed electronic skin (E-skin) that can flex, stretch and sense like human skin.

“The ability to replicate the sense of touch and integrate it into various technologies opens up new possibilities for human-machine interaction and advanced sensory experiences,” said Dr. Akhilesh Gaharwar, professor and director of research for the Department of Biomedical Engineering. “It can potentially revolutionize industries and improve the quality of life for individuals with disabilities.”