Lifeboat Foundation

A stem cell researcher who founded his startup with the psychedelic-loving German billionaire Christian Angermayer, Peyer believes that aging is a disease that humans can fight with pharmaceuticals. He plans to prove it first by identifying disorders and diseases that mimic aging, such as those that cause loss of muscle mass, and then partner with researchers studying medicines for said diseases.

A bold proposal: that by 2050, a 70-year-old will look and feel like they’re 50.

That’s the gamble that 35-year-old James Peyer is taking with this Cambrian Biopharma “longevity startup,” the Times of London reports.

Continue reading “Tech Bro Thinks He’s Close to Cheating Death” »

An ancient Greek drug derived from the saffron plant could improve the treatment of people with severe COVID-19 and reduce the COVID mortality rate by as much as 50%, according to a report published earlier this month in the European Journal of Internal Medicine by an Israeli researcher from the Hebrew University of Jerusalem and Hadassah Medical School.

The drug, colchicine, dates back thousands of years to ancient Egypt, where it was known for its special healing properties. It is one of a few medicines that survived until modern times. Most recently, it has been used to treat and prevent inflammation caused by gout that can lead to painful arthritis and Familial Mediterranean Fever (FMF), which is common among Jewish people of North African descent.

Prof. Ami Schattner researched and analyzed all patients treated in controlled trials of this ancient drug for the past 20 years. He found that among its uses and potential uses, colchicine also appears effective in treating COVID-19.

Continue reading “Ancient Greek drug could cut COVID-19 deaths” »

Their inner workings reside in the realm of physics, but lasers make everyday life possible. Talking on a cell phone or googling COVID stats while your apples and oranges are scanned at the checkout counter—lasers at every step.

Lasers emit intense light at specific wavelengths. At one wavelength, laser beams etch patterns on computer chips that define their circuitry. At telecom wavelengths, lasers fire the enormous volumes of data through optical fibers that make ours the information age.

In 2017, a new kind of laser invented by electrical engineer Boubacar Kante, Ph.D., was recognized as one of the breakthrough inventions of the year by Physics World. With his Bakar Fellows support, Kante is preparing to fabricate a prototype of the new laser and demonstrate its potential for a range of applications from microsurgery to satellite telemetry.

The first volunteer in a Phase I clinical trial of an oral COVID-19 vaccine developed by an Israeli-American company has been screened and enrolled, according to Oravax Medical, a subsidiary of Oramed Pharmaceuticals.

The trial is taking place in South Africa.

Oramed Pharmaceuticals, a clinical-stage pharmaceutical company, is based on technology developed by Hadassah-University Medical Center and run by Israeli CEO Nadav Kidron.

Continue reading “Israeli co. kicks off COVID oral vaccine trial in South Africa” »

Sorry if re-post…

A team of researchers affiliated with a large number of institutions in Japan has developed a vaccine that tricks the immune system into removing senescent cells. In their paper published in the journal Nature Aging, the group describes their vaccine, how it works and how effective it was when given to test mice.

Prior research has shown that part of the aging process is the development of senescent cells —cells that outlive their usefulness but fail to die naturally. Instead, they produce chemicals that can lead to inflammation, aging and a host of other ailments. Prior research has shown that senescence occurs when cells stop dividing. Prior research has also shown that senescent cells can lead to tumor growth in some instances and tumor suppression in others. Senescence also plays a role in tissue repair, and its impacts on the body vary depending on factors such as overall health and age. It is suspected that senescence is related to telomere erosion, and in some cases, environmental factors that lead to cell damage. In this new effort, the researchers have developed a vaccine that creates antibodies that attach to senescent cells, marking them for removal by white blood cells.

Continue reading “A new vaccine that alters senescent cells in a way that pushes the immune system into removing them” »

Fumarate is a terminal electron acceptor in the mammalian electron transport chain, and its reduction sustains mitochondrial functions in hypoxia.

A new report from the Harvard Kennedy School found that China’s rapidly gaining steam in the realms of AI, 5G, quantum computing, biotechnology, and more.

Findings suggest way to help patients heal from dangerous C. difficile.

New research from the University of Virginia School of Medicine sheds light on why a fecal transplant can benefit patients with dangerous recurrent C. difficile infections – and suggests a way to improve patient outcomes.

C. difficile infection causes life-threatening diarrhea, and it often takes hold in patients in hospitals and nursing homes as a result of long-term antibiotic use. Doctors have known that fecal transplants – literally transplanting fecal material from a healthy person into the sick – can improve C. difficile outcomes, but they haven’t fully understood why. The new UVA research offers important answers.

This research can also offer a glimpse at how other forms of thinking might be organized. “It lets us get at this issue of what are the options for a nervous system or behavior,” Weissbourd says. It’s hard to put yourself into the mind of a jellyfish—their life cycle of polyps and spores is utterly alien, their weird array of sensory organs have no analogues to our own. Clytia have specialized balance organs called statocysts; other species of jellyfish have sensors called rhopalia that detect light or chemical changes in the surrounding water.

Researchers have observed some things that could be thought of as akin to our emotional states; for example, Clytia display a unique set of behaviors when spawning, and they perform their feeding action more quickly when they’re hungry. “But they might have a totally different set of nervous system states,” Weissbourd says.

These gene-tweaked jellies are an exciting new platform for research, says Sprecher. Future experiments will improve our understanding of modular nervous systems, not only in jellyfish but in more complex species too. These are ancient creatures, but we know so little about how they see the world, or if it even makes sense to think of them as “seeing” in the way that mammals do. Literally peering inside them could help provide the answers.