Lifeboat Foundation

THE SINGULARITY IS NEARER: When We Merge With A.I., by Ray Kurzweil ______ A central conviction held by artificial intelligence boosters, but largely ignored in public discussions of the technology, is that the ultimate fulfillment of the A.I. revolution will require the deployment of microscopic robots into our veins. In the short term, A.I. may help us print clothing on demand, help prevent cancer and liberate half of the work force. But to…

Hacking my brain implant wouldn’t do much, he asserted, adding, “You might be able to see like some of the brain signals. You might be able to see some of the data that Neuralink’s collecting.”

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Norland Arbaugh did not specify the data that is being collected by Neuralink chip which is almost the size of a coin and contains thousands of electrodes that monitor and stimulate brain activity, as per the company. This information is digitally transmitted to researchers.

Using cryo-electron microscopy, the structural mechanism by which non-coding bridge RNA confers target and donor DNA specificity to IS110 recombinases for programmable DNA recombination is explored.

Summary: Researchers successfully connected lab-grown brain tissues, mimicking the complex networks found in the human brain. This novel method involves linking “neural organoids” with axonal bundles, enabling the study of interregional brain connections and their role in human cognitive functions.

The connected organoids exhibited more sophisticated activity patterns, demonstrating both the generation and synchronization of electrical activity akin to natural brain functions. This breakthrough not only enhances our understanding of brain network development and plasticity but also opens new avenues for researching neurological and psychiatric disorders, offering hope for more effective treatments.

In February 2023, Frontiers in Science published an article titled “Organoid Intelligence (OI): The New Frontier in Biocomputing and Intelligence-in-a-Dish.” Since its publication, this research has sparked significant scientific interest and gained coverage in Forbes, Financial Times, Wall Street Journal, BBC, CNN and many others.

So, what is organoid intelligence and why has this article gathered such attention?

Continue reading “Brain in a dish — the potential of organoid intelligence and biological computing” »

Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles — structures that transport waste or food within cells.

In a recent ACS Nano paper (“The Secret Ballet Inside Multivesicular Bodies”), Luis Mayorga and Diego Masone shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.

A representation of multilayer lipid vesicles inspired by “Color Study: Squares with Concentric Circles,” by the artist Wassily Kandinsky. (Image: ACS Nano 2024, DOI: 10.1021/acsnano.4c01590)

About 170 billion cells are in the brain, and as they go about their regular tasks, they produce waste — a lot of it.

The brain appears to rely on synchronized waves to wash out waste products, including toxins associated with Alzheimer’s disease.

Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), are diseases caused by a defect in one or more genes, which can sometimes result in cognitive and motor impairments. Better understanding the neural underpinning of these disorders and how they affect motor and cognitive abilities could contribute to the development of new treatment strategies.

Researchers at Stanford University and Washington University School of Medicine recently performed a study on mice aimed at investigating the impact of Nf1 gene mutations, which cause the NF1 neurogenetic disorder, on oligodendroglial plasticity, an adaptive brain process known to contribute to cognitive and motor functions.

Their findings, published in Nature Neuroscience, provide strong evidence that Nf1 mutations delay the development of oligodendroglia, a type of glial cells that support the functioning of the central nervous system, causing disruptions in motor learning.

An immunotherapy drug given before surgery instead of chemotherapy meant that over ten times more patients with a certain genetic profile were cancer-free after surgery, according to clinical trial results presented by researchers at UCL and UCLH.

The findings, presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2024, are interim results from the NEOPRISM-CRC phase II clinical trial assessing whether the immunotherapy drug pembrolizumab can improve outcomes for patients with stage two or stage three MMR deficient/MSI-High bowel cancer. The trial was a collaboration among UCL, UCLH, the Christie NHS Foundation Trust in Manchester, St. James’s University Hospital in Leeds, University Hospital Southampton and the University of Glasgow.

Bowel cancer is the fourth most common cancer in the UK, with around 42,900 cases a year. Though still predominantly a cancer that affects older people, cases among the under 50s have been increasing in recent decades.