Lifeboat Foundation

Sensory hypersensitivity in mice with the Grin2b gene mutation found in patients is related to hyperactivity of the anterior cingulate cortex (ACC) and hyperconnectivity between the ACC and other brain regions. Credit: Institute for Basic Science.

Director Kim Eunjoon states, “This new research demonstrates the involvement of the anterior cingulate cortex (ACC), which has been known for its deep association with cognitive and social functions, in sensory hypersensitivity in autism.”

The hyperactivity of the ACC was also associated with the enhanced functional connectivity between the ACC and other brain areas. It is believed both hyperactivity and the hyperconnectivity of the ACC with various other brain regions are involved with sensory hypersensitivity in Grin2b-mutant mice.

Enhanced neuron growth in the hippocampus, achieved through exercise or genetic methods, aids mice in forgetting strong, maladaptive memories, offering potential for new treatments for PTSD or drug addiction.

Researchers at the University of Toronto, Canada, and Kyushu University, Japan, discovered that enhancing neuron production and subsequently altering neural connections in the hippocampus—through exercise or genetic intervention—enables mice to forget memories associated with trauma or drugs. The findings, reported in the journal Molecular Psychiatry, could offer a new approach to treating mental health conditions like post-traumatic stress disorder (PTSD) or drug addiction.

PTSD is a mental health condition that can be triggered by experiencing or seeing a traumatic event, such as a natural disaster, serious accident, or attack. Worldwide, around 3.9% of the general population has PTSD, with symptoms including vivid flashbacks and avoidance behaviors, such as staying away from places or pushing away people that remind them of the traumatic event.

Our guest in this episode is Dr. Mark Kotter. Mark is a neurosurgeon, stem cell biologist, and founder or co-founder of three biotech start-up companies that have collectively raised hundreds of millions of pounds: bit.bio, clock.bio, and Meatable.

In addition, Mark still conducts neurosurgeries on patients weekly at the University of Cambridge.

Continue reading “Stem cells, lab-grown meat, and potential new medical treatments, with Mark Kotter” »

The human genome is massive, and it contains many highly repetitive sequences that confounded researchers for years. Many of these repeats were simply written off as junk DNA that had no function. However, new research is revealing that many of these regions are much more important than we thought. Some of the repetitive portions of the genome are known to be human endogenous retroviruses (HERVs). These sequences originated from viruses that infected human germ cells millions of years ago and affected our evolution. About eight percent of our genome is thought to be made up of HERVs. These HERVs have also been associated with a variety of psychiatric disorders, although the connection is unclear.

A new study reported in Nature Communications has suggested that HERVs are making a significant but unappreciated contribution to the development of psychiatric disorders, and that they may help explain a genetic component of these disorders that is thought to exist but has not yet been identified.

Dive into the intriguing world of Sentient Singularity Theory, a groundbreaking framework that seeks to explain the interconnected nature of consciousness, cosmology, and metaphysics. Created by Tyler Goldstein, this theory posits that every particle and atom in the universe is a conscious participant in the grand dance of existence. Discover how the universe is viewed not just as a mechanical construct but as a living organism, where space, time, matter, and force emerge from the interactions of sentient beings. Join us as we explore the Four Primary Perspectives, the concept of infinite-oneness, and the idea of a self-simulating universe. Through this journey, we’ll challenge conventional understandings and delve deep into the philosophical and metaphysical implications of a Theory of Everyone. Don’t miss this thought-provoking exploration into the very fabric of reality.

#SentientSingularityTheory #Consciousness #Metaphysics #Cosmology #TheoryOfEverything.

Continue reading “Tyler Goldstein’s Theory of Everyone: Sentient Singularity” »

The research team found that long-term urolithin A treatment in mice significantly improved their learning, memory and olfactory function. The treatment also reduced amyloid beta (Aβ) and tau pathologies and improved cellular lysosomal function [1].

The researchers’ findings also suggest that urolithin A is as effective as NAD in promoting mitophagy, positioning it as a potential therapeutic agent for Alzheimer’s disease.

“Our study on mouse models with AD shows that urolithin A, which is a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia,” says Bohr. “Even though the study was conducted on mouse models, the prospects are positive. So far, research has shown promising results for the substance in the muscles, and clinical trials on humans are being planned [3].”

An Engineering team at the University of Hong Kong (HKU) has developed a novel microfluidic technique capable of greatly enhancing applications in materials science and biomedical engineering.

‘Hervs’ date back hundreds of thousands of years – and play an important role in regulating genes.

All the parts of our bodies share an inherent connectivity. This goes much further than “the foot bone’s connected to the … leg bone.” For instance, both hands and feet are connected to a constantly flowing bloodstream, and a nerve network that makes their muscles kick.

So what about the connection recently proposed by some news outlets regarding a simple test involving your palm and thumb? Could it really help diagnose a silent, yet potentially serious problem?

An aneurysm is what we’re referring to here. This is a ballooned segment of an artery—the vessels that supply oxygenated blood to your body tissues. Aneurysms may cause no problems, but if they grow larger, they can weaken, burst and bleed. This is bad enough in most arteries, but imagine if the artery involved were the biggest in your body?