Dr. Petr Cígler and his collaborators are working on refining molecular systems for transporting ribonucleic acid (RNA) molecules into cells. The question of how to effectively deliver RNA to a designated place in the body in order to silence a malfunctioning gene is one of the greatest challenges of the rapidly developing field of gene medicine.
Safe and high-quality fertility preservation is of growing significance for women in clinical trials. Current primary methods for cryopreserving human oocytes are slow freezing and vitrification, but existing techniques pose risks of biochemical toxicity and are restricted in large-scale clinical practice.
From Stanford, Albert Einstein, & Johns Hopkins U: a multimodal agent benchmark to evaluate AI in simulated clinical environments.
From stanford, albert einstein, & johns hopkins U
AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments abs: https://arxiv.org/abs/2405.07960 project page: https://agentclinic.github.io code: https://github.com/samuelschmidgall/agentclinic.
Continue reading “SamuelSchmidgall/AgentClinic: Agent benchmark for medical diagnosis” »
Currently, treatments are largely limited to symptomatic relief rather than addressing the underlying disease progression. Given this gap in treatment options, there is a significant need for new therapies that can protect brain cells and potentially reverse damage.
Cannabinol (CBN), a compound derived from the cannabis plant, has emerged as a candidate for such treatments due to its neuroprotective properties, which are evident without the psychoactive effects associated with other cannabinoids like THC.
Previous studies indicated that CBN could help preserve mitochondrial function in brain cells, an essential factor for cell survival and energy production. Mitochondrial dysfunction is a common feature in several neurodegenerative diseases, often leading to cell death. By focusing on CBN and its derivatives, researchers aimed to develop new pharmacological strategies to prevent or mitigate the cellular mechanisms that lead to neurodegeneration.
Some cancers exploit the protective role of telomeres. New work measuring telomeres offers accurate cancer diagnosis and shows promise for personalised cancer treatment.
In his new book, Dr Alan Herbert gives an honest account of his journey in the discovery of left-handed DNA.
Using an innovative new method, a University of Saskatchewan (USask) researcher is building tiny pseudo-organs from stem cells to help diagnose and treat Alzheimer’s.
In a recent paper published in the International Journal of Psychiatry Research, Dr. Gerard Marx from MX Biotech and Prof. Chaim Gilon from the Hebrew University of Jerusalem present an innovative integration of two notable neuroscience theories—the Global Neuronal Network (GNW) hypothesis and the Tripartite Mechanism of Memory.
As people age, their brains do, too. But if a brain ages prematurely, there is potential for age-related diseases such as mild cognitive impairment, dementia, or Parkinson’s disease. If “brain age” could be easily calculated, then premature brain aging could be addressed before serious health problems occur.
Researchers from Drexel University’s Creativity Research Lab have developed an artificial intelligence technique that can effectively estimate an individual’s brain age based on electroencephalogram (EEG) brain scans. The technology could help to make early, regular screening for degenerative brain diseases more accessible. The work is published in the journal Frontiers in Neuroergonomics.
Led by John Kounios, Ph.D., professor in Drexel’s College of Arts and Sciences and Creativity Research Lab director, the research team used a type of artificial intelligence called machine learning to estimate an individual’s brain age similar to the way one might guess another person’s age based on their physical appearance.
Scientists at the Paul Scherrer Institute (PSI) have for the first time precisely characterized the enzyme styrene oxide isomerase, which can be used to produce valuable chemicals and drug precursors in an environmentally friendly manner. The study appears today in the journal Nature Chemistry.
Enzymes are powerful biomolecules that can be used to produce many substances at ambient conditions. They enable “green” chemistry, which reduces environmental pollution resulting from processes used in synthetic chemistry. One such tool from nature has now been characterized in detail by PSI researchers: the enzyme styrene oxide isomerase. It is the biological version of the Meinwald reaction, an important chemical reaction in organic chemistry.
“The enzyme, discovered decades ago, is made by bacteria,” says Richard Kammerer of PSI’s Biomolecular Research Laboratory. His colleague Xiaodan Li adds: “But because the way it functions was not known, its practical application has been limited up to now.” The two researchers and their team have elucidated the structure of the enzyme as well as the way it works.
