Lifeboat Foundation

Proteins are the molecular machines that sustain every cell and organism, and knowing what they look like will be critical to untangling how they function normally and malfunction in disease. Now researchers have taken a huge stride toward that goal with the development of new machine learning algorithms that can predict the folded shapes of not only proteins but other biomolecules with unprecedented accuracy.

In a paper published today in Nature, Google DeepMind and its spinoff company Isomorphic Labs announced the latest iteration of their AlphaFold program, AlphaFold3, which can predict the structures of proteins, DNA, RNA, ligands and other biomolecules, either alone or bound together in different embraces. The findings follow the tail of a similar update to another deep learning structure-prediction algorithm, called RoseTTAFold All-Atom, which was published in March in Science.

The findings, published in a study in Developmental Cell, reveal that intestinal smooth muscle originates in embryos and forms by the same process that is a hallmark of creating scar tissue when a wound heals.

The smooth muscle sits inside tiny finger-like projections called villi, which absorb fats—also known as lipids—from foods. Contractions of these smooth muscles squeeze absorbed dietary fats through lymphatic capillaries, called lacteals, which send the fats into the systemic blood circulation to produce energy.

Advances in DNA technology enable personalized approaches to healthcare, tailoring treatments and therapies based on an individual’s genetic makeup to improve efficacy and minimize side effects.

If you’re still rinsing your teeth with water after brushing them, it may be time to stop. There are actually some benefits to leaving that extra bit of toothpaste on your teeth. I used to rinse after brushing my teeth — and even went back over them with a wet toothbrush — to remove any remnants of toothpaste left in my mouth. But then I found out from a dentist’s TikTok video that doing that isn’t the most effective method of keeping your chompers in good shape.

Instead, I now spit out as much toothpaste as I can without swishing with water, so I can allow the toothpaste to do its job just a little longer. However, I wasn’t sure why I was doing this — or what the benefits were — until I spoke with an expert.

I talked to Dr. Edmond Hewlett, consumer advisor for the American Dental Association and a professor at UCLA School of Dentistry, to find out why you shouldn’t rinse your mouth with water after brushing your teeth. Here’s the answer. For more tips, here’s why you should floss before brushing your teeth.

The Silicon Hospital is OpenWater’s revolutionary open-source software and hardware platform.

Drug delivery researchers at Oregon State University have developed a device with the potential to improve gene therapy for patients with inherited lung diseases such as cystic fibrosis.

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier. Their goal is to kill primary breast cancer tumors and brain metastases in one treatment, and their research shows the method can shrink breast and brain tumors in laboratory studies.

The team, led by Dipanjan Pan, Dorothy Foehr Huck & J. Lloyd Huck Chair Professor in Nanomedicine and professor of materials science and engineering and of nuclear engineering, published their work —the first of its kind, they said—in ACS Nano.

“Borophene is a very interesting material, as it resembles carbon very closely including its atomic weight and electron structure but with more remarkable properties. Researchers are only starting to explore its applications,” Pan said.

“To the best of our knowledge, this is the first study to understand the biological interactions of borophene and the first report of imparting chirality on borophene structures.”

Researchers have developed a new vaccine technology that has been shown in mice to provide protection against a broad range of coronaviruses with potential for future disease outbreaks—including ones we don’t even know about. The results are published in the journal Nature Nanotechnology.