Lifeboat Foundation

Dev Genes Evol. 2012 Mar;222:29–44. doi: 10.1007/s00427-011‑0387-z. Epub 2012 Feb 23.

Gap junctional proteins are important components of signaling pathways required for the development and ongoing functions of all animal tissues, particularly the nervous system, where they function in the intracellular and extracellular exchange of small signaling factors and ions. In animals whose genomes have been sufficiently sequenced, large families of these proteins, connexins, pannexins, and innexins, have been found, with 25 innexins in the nematode Caenorhabditis elegans Starich et al. (Cell Commun Adhes 8: 311–314, 2001) and at least 37 connexins in the zebrafish Danio rerio Cruciani and Mikalsen (Biol Chem 388:253–264, 2009). Having recently sequenced the medicinal leech Hirudo verbana genome, we now report the presence of 21 innexin genes in this species, nine more than we had previously reported from the analysis of an EST-derived transcriptomic database Dykes and Macagno (Dev Genes Evol 216: 185–97, 2006); Macagno et al. (BMC Genomics 25:407, 2010).

“Corona is the foe. You and I are bros. No discrimination, I’m not virus.”

African students in Shandong, China create a music video to express their best wishes for China amid the #coronavirus outbreak. #StayStrongChina

Optical technologies that can be used to modulate neuronal activity are opening up exciting possibilities for research in neuroscience and biology. Optical tools allow neuroscientists to excite and inhibit neurons or areas of the brain at will. They can thus be used to investigate the function of specific brain circuits or regions, as well as to identify new potential treatments for neurological and psychiatric diseases.

The generation of tethered azobenzene photoswitches targeted at membrane bilayers or linked to ion channels is a pioneering optical technique that could further aid the study of the human brain. This technique, however, particularly when implemented at high light intensities, can lead to a considerable increase in temperature and can thus be harmful to neurons when used repeatedly.

To overcome this limitation, researchers at the Italian Institute of Technology (IIT) in collaboration with Politecnico di Milano, have recently created a new light-sensitive azobenzene compound, dubbed Ziapin2, which can be used to build photoswitches that do not increase in temperature when irradiated with visible light. This new compound, introduced in a paper published in Nature Nanotechnology, partitions into the plasma membrane with a high stability, enabling its thinning and an increased capacitance at a steady state.

Changing a single word can alter the way an AI program judges a job applicant or assesses a medical claim.

Scientists discover a new link between a protein and an eye condition which affects 1.5 million people.

I’ve been reading an excellent book by David Wood, entitled, which was recommended by my pal Steele Hawes. I’ve come to an excellent segment of the book that I will quote now.

“One particular challenge that international trustable monitoring needs to address is the risk of more ever powerful weapon systems being placed under autonomous control by AI systems. New weapons systems, such as swarms of miniature drones, increasingly change their configuration at speeds faster than human reactions can follow. This will lead to increased pressures to transfer control of these systems, at critical moments, from human overseers to AI algorithms. Each individual step along the journey from total human oversight to minimal human oversight might be justified, on grounds of a balance of risk and reward. However, that series of individual decisions adds up to an overall change that is highly dangerous, given the potential for unforeseen defects or design flaws in the AI algorithms being used.”

The fifteen years from 2020 to 2035 could be the most turbulent of human history. Revolutions are gathering pace in four overlapping fields of technology: nanotech, biotech, infotech, and cognotech, or NBIC for short. In combination, these NBIC revolutions offer enormous new possibilities: enormous opportunities and enormous risks.

Department of Homeland Security (DHS) whistleblower Philip Haney was found dead in Amador County, Calif., on Friday, according to local authorities.

Haney, 66, “appeared to have suffered a single, self-inflicted gunshot wound,” the Amador County Sheriff’s Office said in a release. Sheriff and coroner Martin A. Ryan shared the initial details of the case.

“On February 21, 2020 at approximately 10¹² hours, deputies and detectives responded to the area of Highway 124 and Highway 16 in Plymouth to the report of a male subject on the ground with a gunshot wound,” the release read.

“Science hasn’t yet found a way to make complex animals like dogs live forever, so the next best thing we can do is find a way to maintain health for as long as possible during the aging process,” said Church.

And the goal was for this to hit a market and use the income to pay for human trials lasting 10 years.

Combination gene therapy developed at Wyss Institute and Harvard Medical School treats four age-related conditions.

Continue reading “Rejuvenate Bio launches to help dogs live longer, healthier lives” »

An AI algorithm found an antibiotic that wipes out dozens of bacterial strains, including some of the most dangerous drug-resistant bacteria in the world.