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The researchers wanted to know how tardigrades protected themselves against such harsh conditions. So Kunieda and his colleagues began by sequencing the genome of Ramazzottius varieornatus, a species that is particularly stress tolerant. It’s easier to study processes within the tardigrade’s cells when the animal’s genome is inserted into mammalian cells, says Kunieda. So researchers manipulated cultures of human cells to produce pieces of the water bear’s inner machinery to determine which parts were actually giving the animals their resistance.

Eventually, Kunieda and his colleagues discovered that a protein known as Dsup prevented the animal’s DNA from breaking under the stress of radiation and desiccation. And they also found that the tardigrade-tinged human cells were able to suppress X-ray induced damage by about 40%.

“Protection and repair of DNA is a fundamental component of all cells and a central aspect in many human diseases, including cancer and ageing,” says Ingemar Jönsson, an evolutionary ecologist who studies tardigrades at Kristianstad University in Sweden.

Glioblastoma is one of the most common and aggressive forms of brain cancer, and it is particularly difficult to treat. Now, researchers from the University of Pennsylvania School of Medicine have come up with a new approach to treatment for the disease, by growing organoids based on a patient’s own tumor to find the most effective treatments. Digital Trends spoke to senior author Dr. Donald O’Rourke to learn more.

The technique uses mini-brains — pea-sized organoids grown from stem cells which recreate features of full-scale brains. The mini-brains are similar enough to real brains that they can be used for testing out medical treatments to see how a full-sized brain would respond.

The breakthrough in this research is regarding treatment individualization. One of the challenges of treating a complex disease like brain cancer is that different people respond in different ways to the various treatment options available. After surgery has been performed to remove a tumor, doctors typically begin further treatment using radiation or chemotherapy around one month later. That means there isn’t always time to use perform genetic analysis to see which treatment might be best suited for a particular patient — the doctors need to know what will work and start further treatment as soon as possible.

The Race To Find A Cure For Aging Learn about three pioneers working to turn back the clock ~ via Medium #perpetuallife

https://medium.com/discourse/the-race-to-find-a-cure-for-aging-98676b0318dc
We want to look & feel young again, and every year we spend hundreds of billions of dollars on beauty serums, cosmetic surgery, and exotic supplements in the hopes of appearing more vibrant, healthy, and desirable.

After false starts, drugs that manipulate the code of life are finally changing lives.

A new generation of “smart” implantable devices could replace traditional medication to treat a range of chronic conditions, including cardiac disease.

The results from the treatment have been nothing less than miraculous. The beta-thalassemia patient, a European native who needed 16 blood transfusions a year but hasn’t needed even one since the treatment and the sickle-cell patient doesn’t suffer from the pain attacks associated with the condition anymore.

We might one day combine tardigrade DNA into our own cells.

Scientists have developed a system of lasers that can probe inside the human body, much like an ultrasound, but from a distance.

The system can accurately image what’s going on inside a person’s body up to a depth of about six centimeters, according to an MIT press release. While that may not seem like much, it’s still an important first step in removing physical contact from ultrasound scans, as that can sometimes introduce variability in a doctor’s readings.

The system, described in research published in the journal Light: Science & Applications on Friday, uses two lasers: one to generate sound waves that bounce around inside the patient’s body, and the second to detect them as they reflect back.

The device has allowed Chou’s team to investigate how microgravity affects different diseases. The scientists report it has been tremendously effective so far in eliminating cancer cells.

“When placed in a microgravity environment, 80 to 90 per cent of the cells in the four different cancer types we tested – ovarian, breast, nose and lung – were disabled,” said Chou.

Continue reading “Scientists race to use zero gravity to kill the worst cancers” »