A team of researchers has reported in Aging Cell that longer-lived Chinese women have less epigenetic noise in crucial areas of the genome. Order and disorder We have previously reported that the accumulation of epigenetic noise appears […].
For as long as superheroes have been imagined, there’s been a superhero who can regrow limbs. Other animals (like salamanders and sharks) do it, why couldn’t we? Scientists have also tackled this question because, obviously, humans don’t naturally regrow limbs. But before we move on to regrowing limbs ourselves, we need to understand how other species do it.
In a new study, researchers mapped the proteins that kick off limb creation in mice and chicks, finding that a cocktail of just three proteins performs the initial magic.
“People in the field have known a lot of the proteins critical for limb formation, but we found that there are proteins we missed,” said study co-first author ChangHee Lee, research fellow in genetics in the lab of Cliff Tabin at Harvard Medical School.
Long suspected to exist, cancer stem cells were discovered in solid tumors about 20 years ago. Is this the long-sought root cause of cancer? Thousands of scientists now believe so. Then why haven’t you heard about this from your oncologist? We delve into the debate on CSCs, and explore which foods and food supplements are most effective in the lab at killing or blocking cancer stem cells.
Treated participants’ risk of heart attack or stroke dropped by 58%.
The trial: Mesoblast has now tested the therapy, called “rexlemestrocel-L,” in a double-blind, randomized phase 3 trial, which it says is the largest trial of a cell therapy in patients with chronic heart failure. The results have been published in the Journal of the American College of Cardiology.
During this trial, 537 patients with HFrEF received an injection of about 150 million MPCs straight into the muscular tissue of their hearts — or a sham treatment with no injection. All of the participants were also receiving standard heart failure treatment at the time of the trial.
JAMA Network Open commentary focuses on the relationship of pain, depression, and anxiety.
Chronic pain is often accompanied by depression and anxiety. In an invited commentary published in JAMA Network Open, Kurt Kroenke, M.D., of Regenstrief Institute and Indiana University School of Medicine, discusses the relationship between pain, the most common symptom for which individuals visit a physician, and depression and anxiety, the two most prevalent mental health conditions worldwide. He highlights the importance of not neglecting psychological symptoms in patients experiencing pain.
Understanding the Connection.
A collaborative research team has developed a method to connect lab-grown brain tissues, enhancing the understanding of brain development and functions, and paving the way for potential advancements in treating neurological conditions.
The idea of growing a functioning human brain-like tissues in a dish has always sounded pretty far-fetched, even to researchers in the field. Towards the future goal, a Japanese and French research team has developed a technique for connecting lab-grown brain-mimicking tissue in a way that resembles circuits in our brain.
Advancements in Neural Studies.
EPFL researchers have developed GEMLI, a pioneering tool that could democratize and vastly improve how we study the journey of cells from their embryonic state through to specialized roles in the body, as well as their changes in cancer and other diseases.
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Study explores the differences in gut microbiome composition between prediabetic patients and healthy individuals, revealing significant variations that correlate with altered metabolic functions and potential diabetes progression.
Anyone who needs an unusual mole on their skin checked out may soon get to skip a surgical biopsy, and instead have a virtual biopsy. This tool could be a quick, uninvasive way to identify cancerous cells, as well as reveal any cancerous tissue that might be present and left behind during a surgery. This new tool uses lasers to and generate a three-dimensional reconstruction of cells in a tissue under analysis. Cross-sectional images of that tissue can then be assessed, like slides on a microscope. This work may one day be used not only on skin, but on other parts of the body. The work has been reported in Science Advances.
“We’ve not only created something that can replace the current gold-standard pathology slides for diagnosing many conditions, but we actually improved the resolution of these scans so much that we start to pick up information that would be extremely hard to see otherwise,” said senior study author Adam de la Zerda, PhD, an associate professor of structural biology at Stanford University.
Nanomaterials manufacturing, 3D bioprinting, and astronaut eye health were the main research topics aboard the International Space Station on Friday. The Expedition 71 crew members also continued servicing spacesuits and conducted an emergency drill.
The SpaceX Dragon cargo spacecraft recently delivered to the orbital outpost a biotechnology study to demonstrate the in-space production of nanomaterials that mimic DNA. NASA Flight Engineers Jeanette Epps and Mike Barratt worked on the second portion of that experiment on Thursday mixing then treating the research samples for analysis. Epps began her day mixing solutions in the Life Science Glovebox to create specialized nanomaterials. During the afternoon, Barratt applied sound and light treatments to the samples then stowed them aboard Dragon for analysis back on Earth. Results may lead to advanced therapies for space-caused and Earthbound health conditions.
The duo partnered back together at the end of the day for eye scans using standard medical imaging gear found in an optometrist’s on Earth. Barratt operated the hardware with guidance from doctors on the ground peering into Epp’s eyes and examining her retina and optic nerve for the B Complex eye health investigation.
