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Category: biotech/medical – Page 1,845

Neanderthal and Denisovan Y Chromosomes Sequenced – Surprise When Compared to Modern Human DNA

Neanderthals have adopted male sex chromosome from modern humans.

In 1997, the very first Neanderthal DNA sequence — just a small part of the mitochondrial genome — was determined from an individual discovered in the Neander Valley, Germany, in 1856. Since then, improvements in molecular techniques have enabled scientists at the Max Planck Institute for Evolutionary Anthropology to determine high quality sequences of the autosomal genomes of several Neanderthals, and led to the discovery of an entirely new group of extinct humans, the Denisovans, who were relatives of the Neanderthals in Asia.

However, because all specimens well-preserved enough to yield sufficient amounts of DNA have been from female individuals, comprehensive studies of the Y chromosomes of Neanderthals and Denisovans have not yet been possible. Unlike the rest of the autosomal genome, which represents a rich tapestry of thousands of genealogies of any individual’s ancestors, Y chromosomes have a peculiar mode of inheritance — they are passed exclusively from father to son. Y chromosomes, and also the maternally-inherited mitochondrial DNA, have been extremely valuable for studying human history.

160 Genes Linked to Brain Shrinkage in Study of 45,000 Adults

Researchers have identified 160 genes linked to brain shrinkage in adults. The genes appear to be involved in brain development, vascular and neurodegenerative diseases, and some psychiatric conditions.0 genes linked to brain shrinkage in adults. The genes appear to be involved in brain development, vascular and neurodegenerative diseases, and some psychiatric conditions.0 genes linked to brain shrinkage in adults. The genes appear to be involved in brain development, vascular and neurodegenerative diseases, and some psychiatric conditions.

Epigenetic Clocks: Which Has The Best Correlation For Aging and Age-Related Diseases?

11 epigenetic clocks have been published since 2011, but which is best for predicting aging and age-related disease? In this video, I present findings from a recent publication, “Underlying features of epigenetic aging clocks in vitro and in vivo”, that compared data for 11 epigenetic clocks, and derived a new epigenetic clock, the meta-clock.

University Obtains New Patent for Poison Ivy, Oak Vaccine

Circa 2019

OXFORD, Miss. – The University of Mississippi has been issued its fourth patent for a product that could prevent the painful itching and rash due to exposure to poison ivy, poison oak and poison sumac.

The compound is based on research conducted in the UM School of Pharmacy and at ElSohly Laboratories Inc. Hapten Sciences, a Memphis-based biopharmaceutical company, obtained a worldwide, exclusive license for the technology from the university in 2010 and has conducted extensive preclinical and clinical development work since then.

“We are delighted to be a partner with the University of Mississippi to develop this novel and important product candidate, and look forward to continued development to seek regulatory approval so that we can provide it to people that suffer from contact dermatitis caused by poison ivy, oak and sumac,” said Raymond J. Hage Jr., CEO and president of Hapten Sciences.

Humans live much longer than chimps due to a slower epigenetic ‘clock’

Lil bits of info on DNA methylation, clocks.

Breakthrough advances in medicine and better nutrition have dramatically improved the longevity of the average human over the past two centuries. But that’s not to say that some couldn’t go on to live a long life even before the advent of modern medicine. As long as they were spared by disease, wars, and other risks that can bring an untimely death, humans could live to see their 70s, 80s, and even reach 100 years old as far back as ancient Rome.

The longevity of humans is somewhat exceptional among primates. Chimpanzees, our closest living relatives, rarely make it past age 50, despite them sharing over 99% of our DNA. In a new study, researchers think they’ve found our secret: chemical changes along our genome that occurred around 7–8 million years ago when our ancestors branched away from the lineage of chimps.

Slower ticker

There are tens of thousands of genes in the human genome, but that doesn’t mean all of them are active. For instance, through the methylation of DNA across certain sites of the genetic sequence, genes are locked in the “off” position. These modifications, known as epigenetic changes (‘epi’ means ‘above’ in Greek), do not alter the DNA sequence itself but, rather, simply regulate the activity of genes.

How China Is Closing In on Its Own Digital Currency

While there’s no launch date yet, the People’s Bank of China is likely to be the first major central bank to issue a digital version of its currency, the yuan, seeking to keep up with — and control of — a rapidly digitizing economy. Trials have been held this year in a handful of cities and tests have started with some e-wallets and online apps, with the Covid-19 pandemic and need for social distancing providing a new sense of urgency. Unlike cryptocurrencies such as Bitcoin, dealing in the digital yuan won’t have any presumption of anonymity, and its value will be as stable as the physical yuan, which will be sticking around too. Behind China’s rush is a desire to manage technological change on its own terms. As one PBOC official put it, currency isn’t only an economic issue, it’s also about sovereignty.

Not all the details are out, but according to new patents registered by the PBOC and official speeches, it could work something like this: Consumers and businesses would download a digital wallet onto their mobile phone and fill it with money from their account at a commercial bank — similar to going to an ATM. They then use that money — dubbed Digital Currency Electronic Payment, or DCEP — like cash to make and receive payments directly with anyone else who also has a digital wallet. Some questions remain, including the impact on Big Tech companies such as Ant Group Co. and Tencent Holdings Ltd. that already offer payment services.

World’s smallest fine particle air pollution sensor fits inside a phone

Air pollution involving very fine dust, such as PM2.5 particles, poses a serious threat to human health. Scientists in Austria have developed what they call the smallest particle sensor in the world, designed specifically to detect these harmful pollutants and offer a highly localized picture of air quality by being integrated into wearables and mobile devices.

According to the World Health Organization, air pollution contributes to more than four million premature deaths each year. While PM10 particles with a diameter of 10 microns or less can also make their way into their lungs, the finer PM2.5 particles are even more dangerous, as they can penetrate the lung barrier, slip into the blood stream and, through chronic exposure, cause severe forms of cardiovascular and respiratory disease, along with other health problems.

Concentrations of PM2.5 particles can be gauged through monitoring stations positioned around cities and regions, in fact the US Environmental Protection Agency uses a nationwide network of these stations to track air quality trends. But scientists from Austria’s Graz University of Technology (TU Graz) have been working on a more cost-effective, compact and versatile solution that can alert individual users of dangerous conditions in real time.