Lifeboat Foundation

H/T Dr. Jason Williams

Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research.

The study, conducted in mice and published in the Journal of Experimental Medicine, is the first to show that creatine uptake is critical to the anti-tumor activities of CD8 T cells, also known as killer T cells, the foot soldiers of the immune system. The researchers also found that creatine supplementation can improve the efficacy of existing immunotherapies.

“Because oral creatine supplements have been broadly utilized by bodybuilders and athletes for the past three decades, existing data suggest they are likely safe when taken at appropriate doses,” said Lili Yang, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and the study’s senior author. “This could provide a clear and expedient path forward for the use of creatine supplementation to enhance existing cancer immunotherapies.”

https://youtube.com/watch?v=Hw4GWnM2VXY

Brain-connected machines that capture and translate electrical signals are showing great promise across a number of areas, but one with massive potential is the world of prosthetics. Scientists exploring these possibilities at Johns Hopkins University are now reporting a big breakthrough, demonstrating a system that enables a quadriplegic to control two prosthetics arms at once using only his thoughts, and also feel a sense of touch coming back the other way.

The team at Johns Hopkins University has been making some exciting progress in this area through its Revolutionizing Prosthetics program, which was launched by DARPA in 2006. In 2016, we saw a double amputee use his brain to control two of the team’s Modular Prosthetic Limbs (MPLs), bilateral shoulder-level prosthetics that enabled him to do things like move cups between shelves, a first for this kind of research.

Continue reading “First bilateral brain implant gives paraplegic a two-handed sense of touch” »

Researchers now have shown that they are instead made up of many individual bioelectric units generating energy- like a Tesla Battery. https://embopress.org/doi/10.15252/embj.2018101056&h=AT3…nuqUCir7ik

https://bit.ly/2J4Tkho&h=AT1YJICM5AliiHbU1dzQWsUOBj2Pv4x…AZG5eAMbU–\-\DuoKFZH11ht3gbqMTwxduJkRJYCYZr7uE11trWGGCm-ecSp9kMw

The Burzynski Patient Group mission is to raise public awareness of Dr. Stanislaw Burzynski’s breakthrough treatment for cancer using Antineoplastons and gene-targeted therapy.

Genetic differences in the immune system shape the collections of bacteria that colonize the digestive system, according to new research by scientists at the University of Chicago.

In carefully controlled experiments using germ-free mice populated with microbes from conventionally raised mice, the researchers showed that while the makeup of the microbial input largely determined the resulting microbiome of the recipients, genetic differences between strains of mice played a role as well.

“When the input is standardized, you can compare mice of different genetic strains and see what these genetics do to the microbiome in recipient mice,” said microbiome researcher Alexander Chervonsky, MD, Ph.D., a senior author of the new study, published in Cell Reports. “This approach allowed us to tell whether there was a genetic influence, and indeed there is. So, the next question was what mechanisms are involved?”

As investors await results from the first U.S. clinical trials of the gene-editing system known as Crispr, scientists are focused on finding ways to administer it directly into humans, according to the technology’s co-inventor, Jennifer Doudna.

Right now, in studies using Crispr that have treated patients, researchers have had to extract their cells to be able to make edits to faulty DNA before infusing them back into the body for treatment. Being able to do precise edits directly inside humans, animals or plants could open the door to new applications, Doudna said.

A chance finding 10 years ago led to the creation by researchers of the Spanish National Cancer Research Centre (CNIO) of the first mice born with much longer telomeres than normal in their species. Telomeres shorten throughout life, so older organisms have shorter telomeres. Given this relationship between telomeres and aging, the scientists launched a study generating mice in which 100 percent of their cells had hyper-long telomeres. The findings are published in Nature Communications and show only positive consequences: The animals with hyper-long telomeres live longer and in better health, free from cancer and obesity. This marks the first time that longevity has been significantly increased without any genetic modification.

“This finding supports the idea that, when it comes to determining longevity, genes are not the only thing to consider,” says Maria Blasco, head of the CNIO Telomeres and Telomerase Group and intellectual author of the paper. “There is margin for extending life without altering the genes.”

Telomeres form the ends of chromosomes in the nucleus of each cell in the body. Their function is to protect the integrity of the genetic information in DNA. Whenever the cells divide the telomeres, they are slightly shortened, so one of the main characteristics of aging is the accumulation of shorter telomeres in cells. “Telomere shortening is considered to be one of the primary causes of aging, given that short telomeres cause aging of the organism and reduce longevity,” the authors write in a paper published in Nature Communications.

Are you ready for the future? A Transhumanist future? One where everyone around you—friends, family, and neighbors—has dipped into the transhumanist punch bowl. A future of contact lenses that see in the dark, endoskeleton attached artificial limbs that lift a half-ton, and brain chip implants that read your thoughts and instantly communicate them to others. Sound crazy? Indeed, it does. Nevertheless, it’s coming soon. Very soon. In fact, much of the technology already exists. Some of it’s being sold commercially at your local superstore or being tested in laboratories right now around the world.

We’ve all heard about driverless test cars on the roads and how doctors in France are replacing people’s hearts with permanent robotic ones, but did you know there’s already a multi-billion dollar market for brain wave reading headsets? Using electroencephalography (EEG) sensors that pick up and monitor brain activity, NeuroSky’s MindWave can attach to Google Glass and allow you to take a picture and post it to Facebook and Twitter just by thinking about it. Other headsets allow you to play video games on your iPhone just with your thoughts too. In fact, well over a year ago now, the first mind-to-mind communication took place. A researcher in India projected a thought to a colleague in France, and using their headsets, they understood each other. Telepathy went from science fiction to reality.

The history of transhumanism—the burgeoning field of science and radical tech used to describe robotic implants, prosthetics, and cyborg-like enhancements in the human being and its experience—has come a long way since scientists began throwing around the term a half century ago. What a difference a generation or two makes. Today a thriving pro-cyborg medical industry is setting the stage for trillion-dollar markets that will remake the human experience. Five million people in America suffer from Alzheimer’s, but a new surgery that involves installing brain implants is showing promise in restoring people’s memory and improving lives. The use of medical and microchip implants, whether in the brain or not, are expected to surge in the coming years. Some experts surmise as many as half of Americans will have implants by 2020. I already have one in my hand. It’s truly a new age for humans.

Engineering biology is already transforming technology and science, and a consortium of researchers across many disciplines in the international Genome Project-write is calling for more discussion among scientists, policy makers and the general public to shepherd future development. In a policy forum article published in the October 18 issue of Science, the authors outline the technological advances needed to secure the transformative future of synthetic biology and express their concerns that the implementation of the relatively new discipline remains safe and responsible.

Two researchers with the University of Tennessee Institute of Agriculture are co-authors on the piece titled “Technological challenges and milestones for writing genomes: synthetic genomics requires improved technologies.” Neal Stewart and Scott Lenaghan with the UTIA departments of Plant Sciences and Food Science, respectively, join Nili Ostrov, a Ph.D. research fellow in genetics at Harvard Medical School, and 18 other leading scientists from a number of institutions and disciplines, in outlining a potential timeline for the development of what they call transformative advances to science and society.

Stewart and Lenaghan are the co-directors of the UT Center for Agricultural Synthetic Biology (CASB). Formed in 2018, Stewart says CASB is the first synthetic biology center in the world aimed specifically at improved agriculture. A professor of plant sciences in the UT Herbert College of Agriculture, Stewart also holds the endowed Racheff Chair of Excellence in Plant Molecular Genetics. Lenaghan is an assistant professor in the Department of Food Science who also holds an adjunct position in the UT Mechanical, Aerospace, and Biomedical Engineering (MABE) Department.