Lifeboat Foundation

Scientists show the approach can kill cells that cause hardening of heart tissue in mice.

Ira Pastor, ideaXme longevity and aging ambassador and Founder of Bioquark, interviews Robin Farmanfarmaian, medical futurist, bestselling author, professional speaker, and CEO and Co-Founder of ArO.

Ira Pastor Comments:

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In experiments in mice, Johns Hopkins Medicine researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.

A report on the research, published Sept. 16 in the journal Brain, details the new approach, which selectively circumvents the immune response against foreign cells, allowing transplanted cells to survive, thrive and protect brain tissue long after stopping immune-suppressing drugs.

The ability to successfully transplant healthy cells into the brain without the need for conventional anti-rejection drugs could advance the search for therapies that help children born with a rare but devastating class of genetic diseases in which myelin, the protective coating around neurons that helps them send messages, does not form normally. Approximately 1 of every 100,000 children born in the U.S. will have one of these diseases, such as Pelizaeus-Merzbacher disease. This disorder is characterized by infants missing developmental milestones such as sitting and walking, having involuntary muscle spasms, and potentially experiencing partial paralysis of the arms and legs, all caused by a genetic mutation in the genes that form myelin.

The replacement of animals as test subjects is one step closer to reality with the successful testing of multi-organ “human-on-a-chip” models to recapitulate the 28-day experiments typically used in animals to evaluate the systemic toxicity of drug and cosmetic compounds. As published and featured as a frontispiece in the prestigious peer-reviewed scientific journal Advanced Functional Materials, the microfluidic device with interlinking modules containing human-derived heart, liver, skeletal muscle and nervous system cells was able to maintain cellular viability and record cellular function in real-time for 28 days.

The University of Central Florida (UCF) in collaboration with the Florida biotech firm Hesperos, Inc., has shown that one of its innovative four-organ in vitro (out of body) model systems is able to realistically replicate in vivo (in body) responses to sustained drug dosing of human cells.

“The technology could allow us, in the very near future, to move chronic drug experiments from animal models to these novel human in vitro models,” said Hesperos Chief Scientist James J. Hickman, who is a Professor at UCF’s NanoScience Technology Center.

Another magical flavonoid!

Researchers have created a compound, that when tested in mice, was able to promote the reconstruction of the myelin sheath surrounding neuronal axons. These findings could pave the way to a new treatment for combating demyelinating conditions such as multiple sclerosis (MS). The findings were published in Glia. “I think we’ll know in about a year if this is the exact right drug to try in human clinical trials,” explained senior study author Larry Sherman, Ph.D., in a recent press release.

“If it’s not, we know from the mouse studies that this approach can work. The question is, can this drug be adapted to bigger human brains?”

Continue reading “Compound Created to Help Reconstruct Myelin in Multiple Sclerosis” »

Anybody can cook, even if it’s only a fried egg – but not just anyone has the discipline to fast. This ancient practice of abstaining from eating for a day, or sometimes even a week or more has a history of curing a whole host of health problems, but even a brief fast can completely re-boot your immune system.

This practice isn’t without criticism by modern nutritionists and unbelievers, but research implies that when the body is hungry in short spurts, it can kick-start stem cells into producing new white blood cells.

White blood cells, also known as leukocytes, are the cells which the immune system uses to fight against foreign invaders like viruses and bad bacteria.

“DNA is like a computer program but far, far more advanced than any software ever created.” Bill Gates wrote this in 1995, long before synthetic biology – a scientific discipline focused on reading, writing, and editing DNA – was being harnessed to program living cells. Today, the cost to order a custom DNA sequence has fallen faster than Moore’s law; perhaps that’s why the Microsoft founder is turning a significant part of his attention, and wallet, towards this exciting field.

Bill Gates is not the only tech founder billionaire that sees a parallel between bits and biology, either. Many other tech founders – the same people that made their money programming 1s and 0s – are now investing in biotech founders poised to make their own fortunes by programming A’s, T’s, G’s and C’s.

The industry has raised more than $12.3B in the last 10 years and last year, 98 synthetic biology companies collectively raised $3.8 billion, compared to just under $400 million total invested less than a decade ago. Synthetic biology companies are disrupting nearly every industry, from agriculture to medicine to cell-based meats. Engineered microorganisms are even being used to produce more sustainable fabrics and manufacture biofuels from recycled carbon emissions.

Lifeb.

Once tooth enamel breaks or wears away it’s over – it doesn’t grow back. That’s why dentists have to plug in the gaps with artificial fillings. But now, a team of scientists from China’s Zhejiang University and Jiujiang Research Institute says it has finally figured out how to regrow tooth enamel, a development that could totally upend dental care. The team developed a gel that has been found to help mouse teeth regrow enamel within 48 hours. The research has been published in the journal Science Advances.

What exactly is enamel and why can’t it regrow? It is a mineralized substance with a highly complicated structure that covers the surface of teeth. The structure is made up of enamel rods interwoven with inter-rods in a fish scale pattern which makes it the hardest tissue in the human body. It is initially formed biologically but once mature it becomes acellular, meaning it becomes devoid of the ability to self-repair. This is why cavities (tooth decay) are one of the most prevalent chronic diseases in humans.

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