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Category: biotech/medical – Page 1,947

Scientists find a switch to flip and turn off breast cancer growth and metastasis

Researchers at Tulane University School of Medicine identified a gene that causes an aggressive form of breast cancer to rapidly grow. More importantly, they have also discovered a way to “turn it off” and inhibit cancer from occurring. The animal study results have been so compelling that the team is now working on FDA approval to begin clinical trials and has published details in the journal Scientific Reports.

The team led by Dr. Reza Izadpanah examined the role two genes, including one whose involvement in cancer was discovered by Tulane researchers, play in causing triple negative breast cancer (TNBC). TNBC is considered to be the most aggressive of breast cancers, with a much poorer prognosis for treatment and survival. Izadpanah’s team specifically identified an inhibitor of the TRAF3IP2 gene, which was proven to suppress the growth and spread (metastasis) of TNBC in mouse models that closely resemble humans.

In parallel studies looking at a duo of genes—TRAF3IP2 and Rab27a, which play roles in the secretion of substances that can cause —the research teams studied what happens when they were stopped from functioning. Suppressing the expression of either gene led to a decline in both and the spread of cancer to other organs. Izadpanah says that when Rab27a was silenced, the tumor did not grow but was still spreading a small number of cancer cells to other parts of the body. However, when the TRAF3IP2 gene was turned off, they found no spread (known as “metastasis” or “micrometastasis”) of the original tumor cells for a full year following the treatment. Even more beneficial, inhibiting the TRAF3IP2 gene not only stopped future tumor growth but caused existing tumors to shrink to undetectable levels.

Chasing immortality | The Future is Now

#Eternal life might not be attainable in the near future, but genetic engineers and doctors are working on new life extension technology. The research could lead to keeping our bodies young, and scientists are developing ways of downloading our brain’s consciousness onto digital media once the body is at the end of its life cycle.

#RT #Documentary offers you in-depth documentary films on topics that will leave no one indifferent. It’s not just front-page stories and global events, but issues that extend beyond the headlines. Social and environmental issues, shocking traditions, intriguing personalities, history, sports and so much more – we have documentaries to suit every taste. RTD’s film crews travel far and wide to bring you diverse and compelling stories. Discover the world with us!

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Genetically Modifying Humans to Reverse Aging — Today – EP15: Liz Parrish (BioViva)

SEE MORE EPISODES like this https://podcast.hyperwellbeing.com/

In this fifteenth episode, Liz Parrish shares her quest for radical life extension and details her two completed gene therapies. She describes the regenerative medical tourism available today for increased lifespan and costs. She relates her company’s mission to create a human that regenerates faster than they degenerate. She details her upcoming gene therapies, including upgraded IQ.

➢ Episode show notes https://bit.ly/2BztscJ
➢ Episode transcript https://bit.ly/2A2adrN

Twitter @hyperwellbeing
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Quantified Health, Wellness & Aging is a podcast about the latest products and services, technologies and people — pushing forward a new frontier. The audience is two-fold. Industry professionals who wish to track a trillion-dollar shift and new growth markets. Savvy consumers who wish to stay at the forefront, live longer and in an optimal state. Bimonthly, Lee S Dryburgh hosts a pioneer for an in-depth discussion.

Wear masks in public, WHO says in new advice

The World Health Organization (WHO) has changed its advice on face masks, saying they should be worn in public where social distancing is not possible to help stop the spread of coronavirus.

The global body said new information showed they could provide “a barrier for potentially infectious droplets”.

Some countries already recommend or mandate face coverings in public.

Scientists find link between COVID-19 severity and genetics

Chinese scientists also found that patients with blood type A were more likely to develop a severe case of COVID-19, according to the Times.

While the Chinese study does support the new study, questions remain on why blood type affects the severity of the illness. “That is haunting me, quite honestly,” said Franke.

The locus where the blood-type gene is located also contains DNA that acts an on-off switch for a gene producing a protein that triggers strong immune responses.

Coronavirus vaccine: White House narrows focus, a billionaire scientist jumps in the race

Global efforts to develop a coronavirus vaccine continue, even as mass protests against racial injustice and police brutality persist in cities across the United States and around the world, raising concerns that the gatherings could spark new waves of infection.

As the number of confirmed coronavirus cases rose to nearly 6.3 million worldwide, experts reaffirmed their hope that at least one promising vaccine candidate could be identified by the end of the year.

Lancet, NEJM retract Covid-19 studies that sparked backlash

The Lancet, one of the world’s top medical journals, on Thursday retracted an influential study that raised alarms about the safety of the experimental Covid-19 treatments chloroquine and hydroxychloroquine amid scrutiny of the data underlying the paper.

Just over an hour later, the New England Journal of Medicine retracted a separate study, focused on blood pressure medications in Covid-19, that relied on data from the same company.

The journals said the authors of the paper were unable to complete an independent audit of the data underpinning their analyses.

The Safety of Stimulant Medication Use in Cardiovascular and Arrhythmia Patients

· 24 mins ·

Safety was the reason the WHO stopped clinical trials of a drug that is not even an amphetamine. This happened before the racial divide, distraction, and mass confusion.

So let US think with a clear head. If Hydroxychloroquine is unsafe because of heart concerns, why give children amphetamines for ADHD, when marijuana and other natural measures offer many more safer alternatives? I know of them, why don’t the WHO and FDA, who know more than I do know as well? I can start a w… See More.

First-line stimulant class medications, such as methylphenidate and amphetamine formulations are FDA approved for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. It is estimated that 4.4% of US adults experience some symptoms and disabilities of ADHD. However adults receive 32% of all issued stimulant prescriptions.1 Off-label treatment for conditions including weight management, fatigue related to depression, stroke, traumatic brain injury, or hyper-somnolence due to Obstructive Sleep Apnea (OSA) may account for the high prevalence of stimulant use in adults. Such conditions are frequently associated with history or risk of cardiovascular disease. Of note, OSA and other forms of sleep-disordered breathing have unfavorable effects on cardiovascular physiology, predisposing affected individuals to cardiovascular disease and cardiac arrhythmias.2,3

Due to reports of cardiovascular adverse events and observed physiological effects, the package inserts for stimulant drugs warn against use in patients with preexisting heart disease or cardiac structural abnormalities due to risk of sudden death, stroke, and myocardial infarction (MI).4–6 Furthermore, the FDA issued a safety announcement in 2011 stating that stimulant products and atomoxetine should not be used in patients with serious heart problems, or for whom an increase in blood pressure (BP) or heart rate (HR) would be problematic.7 Table 1 summarizes the available stimulant and stimulant-like medications, including those referenced by the FDA. Debate remains on the safety of stimulants in the cardiovascular population. Specifically, the use of stimulants in patients with history of or susceptible to arrhythmias has not been studied. In an effort to elucidate risk, interpretation of current evidence surrounding stimulant and stimulant-like drugs is offered.

Optimising Performance of the Human Body and Mind with Defense Advanced Research Projects

Ira Pastor, ideaXme life sciences ambassador, interviews Dr. Eric Van Gieson, Program Manager in the Biological Technologies Office (BTO) at DARPA. https://www.darpa.mil/staff/dr-eric-van-gieson

Ira Pastor Comments

On several recent ideaXme episodes, we have spent time on different topics pertaining to human health, disease, degeneration and aging, focused on a variety of therapeutic and preventative interventions being developed in the private sector of the economy, both here in the U.S. and more broadly globally.

We’ve also had representatives from various independent agencies of the United States Federal Government, the UK government (UKRI), and other foreign governmental agencies, join us to discuss many of the exciting public sector discoveries and development occurring, that possess massive trickle down benefits to the general public.

For example, over the last few months ideaXme has had several guests that have worked in different roles within NASA (U.S. National Aeronautics and Space Administration) talking about how research in space, can help improve the lives of us on Earth, where topics have included the bio-dynamics of sub-orbital flight training, astrobiology on the International Space Station (ISS), and even isolation chamber training for physical / psychological dynamics pertaining to future missions back to the Moon and Mars.

DARPA:

Continue reading “Optimising Performance of the Human Body and Mind with Defense Advanced Research Projects” | >

Way too many Americans have gargled with bleach, sprayed their bodies with disinfectants to prevent COVID-19

Nearly 4 in 10 American adults reported engaging in dangerous cleaning practices to prevent COVID-19, such as washing food with bleach, using household disinfecting products on their skin or intentionally inhaling vapors from cleaning products, according to a recent survey.

A report from the Centers for Disease Control and Prevention (CDC) follows an earlier study describing an increase in calls to poison control centers regarding exposure to household cleaners, during the COVID-19 pandemic.