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Category: biotech/medical – Page 2,007

Turning on the ‘off switch’ in cancer cells

A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer.

The discovery marks a critical step toward developing a potential new class of anti– drugs that enhance the activity of a prevalent family of tumor suppressor proteins, the authors say.

The findings, which appear in the leading life sciences journal Cell, are less a story of what than how.

New therapeutic options for multiple sclerosis in sight

Multiple sclerosis (MS) is known as “the disease with a thousand faces” because symptoms and progression can vary dramatically from patient to patient. But every MS patient has one thing in common: Cells of their body’s own immune system migrate to the brain, where they destroy the myelin sheath—the protective outer layer of the nerve fibers. As a result, an electrical short circuit occurs, preventing the nerve signals from being transmitted properly.

Many MS medications impair immune memory

Researchers don’t yet know exactly which are involved in stripping away the myelin sheath. Autoreactive T and B , which wrongly identify the myelin sheath as a foreign body, travel to the brain and initiate the disease. “Up until now, MS drugs have essentially targeted these T and B cells, both of which are part of the acquired ,” says Dr. Alexander Mildner, a scientist at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the senior author of the paper now published in Nature Immunology.

DARPA-funded microchip technology optimizes convalescent plasma therapy for COVID-19 patients

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Doctors and researchers are just beginning to document and understand the effects of heart disease in complicating and endangering recovery from the COVID-19 virus, as well as the potential impact of COVID-19 on the heart. In a new Loyola Medicine video, “Heart Disease and COVID-19,” cardiologist Asim Babar, MD, recommends that individuals with heart disease take especially good care of their health and heart during this pandemic.

Israeli researchers: Hackers aiming to exploit government financial aid

#Hackers are seeking to exploit the roll-out of government financial relief plans to fill their own pockets at the expense of businesses and affected workers, Israeli cyber researchers have revealed.

Hackers are exploiting the rollout of governmental financial relief to fill their pockets at the expense of businesses and affected workers, according to Israeli cyber researchers.

In recent weeks, governments have sought to ease cash-flow shortages and avoid a recession with ambitious stimulus packages and grants to households, including a massive $2 trillion economic package in the United States.

According to researchers at Israeli cybersecurity giant Check Point, a major increase in malicious and suspicious domains related to relief packages has been registered in recent weeks. The hackers aim to scam individuals into providing personal information, thereby stealing money or committing fraud.

“To do this, they are evolving the scam and phishing techniques that they have been using successfully since the start of the pandemic in January,” the researchers wrote in a recent report.

Kentucky reports highest coronavirus infection increase after a week of protests to reopen state

Democratic Kentucky Governor Andy Beshear announced Sunday that the state had set a grim record with 273 new confirmed cases of the coronavirus, the highest single-day rise to date. Kentucky’s increase in infected individuals comes after protesters took to the streets throughout the week to call for the state to be reopened.

With the 273 additional confirmed infections, Kentucky now has 2,960 cases of the novel virus and 1,122 recoveries. Beshear also announced four new deaths on Sunday, bringing the total number of fatalities across the state to 148.

“We are still in the midst of this fight against a deadly and highly contagious virus,” the governor said during his daily news conference. “Let’s make sure, as much as we’re looking at those benchmarks and we’re looking at the future, that we are acting in the present and we are doing the things that it takes to protect one another.”

MIMIVIRE is a defence system in mimivirus that confers resistance to virophage

👽 Giant Viruses : “Mimiviruses”

(Jan 2016)

Fyodor R., issue 3, refund institute

Biologist Didier Raoult is one of the leading experts in Microbiology, he is all over TV right now in France, providing leadership during this Covid outbreak of 2020.

👽 What are they?

Mimiviruses are so large that they are visible under a light microscope. Around half a micrometre across, and first found infecting amoebae living in a water tower, they boast genomes that are larger than those of some bacteria. They are distantly related to viruses that include smallpox, but unlike most viruses, they have genes to make amino acids, DNA letters and complex proteins.

Gigantic mimiviruses fend off invaders using defences similar to the CRISPR system deployed by bacteria and other microorganisms, French researchers report. They say that the discovery of a working immune system in a mimivirus bolsters their claim that the giant virus represents a new branch in the tree of life.

Continue reading “MIMIVIRE is a defence system in mimivirus that confers resistance to virophage” | >

Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019

The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated.

Methods

A total of 173 patients with SARS-CoV-2 infection were enrolled. Their serial plasma samples (n=535) collected during the hospitalization were tested for total antibodies (Ab), IgM and IgG against SARS-CoV-2. The dynamics of antibodies with the disease progress was analyzed.

CRISPR Therapeutics braces for ‘severe impact’ from COVID-19 crisis

April 1, 2020

It was supposed to be an exciting time of next-gen science, where CRISPR gene editing was being used in the first series of human trials in the hope this tech could help cure a range of diseases.

But one of its proponents, CRISPR Therapeutics, has, alongside a growing number of biopharmas, admitted the spreading COVID-19 pandemic is starting to see it be “adversely affected.”

In a Securities and Exchange Commission filing Tuesday, the biotech said: “We are conducting a number of clinical trials for product candidates in the fields of severe hemoglobinopathies and immuno-oncology in geographies which are affected by the coronavirus pandemic.