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Scientists can now discover how the fine details of gene activity differ from one cell type to another in a tissue sample, thanks to a technique invented by Weill Cornell Medicine researchers.

The technique, described in a paper published Oct. 15 in Nature Biotechnology, will enable biologists to better understand the distinct molecular workings of different cell types in the body. It may also enable the improved understanding and treatment of diseases caused by abnormal gene activity.

“An individual gene can ‘say’ different things, and the true meaning often requires listening to entire phrases, rather than single words,” said senior study author Dr. Hagen U. Tilgner, assistant professor of neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine. “Our new method essentially allows us to record complete phrases, called isoforms, that each gene expresses in each cell.”

I just love it when the reductionists are wrong…again. I can not help myself. bigsmile

University of Nebraska-Lincoln researchers have found revolutionary evidence that an evolutionary phenomenon at work in complex organisms is at play in their single-celled counterparts, too.

Species most often evolve through DNA mutations inherited by successive generations. A few decades ago, researchers began discovering that multicellular species can also evolve through epigenetics: traits originating from the inheritance of cellular proteins that control access to an organism’s DNA, rather than genetic changes.

Continue reading “Evolution sans mutation discovered in single-celled archaea” »

Space, Oceans, Literature, Entertainment, Sports, Medicine, Fashion, Longevity — Honored to be among this group of thinkers, coming up with the innovative ideas that shape the future — http://radioideaxme.com

A ground-breaking study has shown it takes a matter of hours for billions of minute plastic nanoparticles to become embedded throughout the major organs of a marine organism.

The research, led by the University of Plymouth, examined the uptake of nanoparticles by a commercially important mollusc, the great scallop (Pecten maximus).

After six hours exposure in the laboratory, billions of particles measuring 250nm (around 0.00025mm) had accumulated within the scallop’s intestines.

Continue reading “Billions of nanoplastics accumulate in marine organisms within six hours” »

Matter is all around us. As human beings, we’re made of it. Matter is the “stuff” that makes up the physical world as we know it; a collection of atoms made up of particles called protons, electrons and neutrons.

Part of my work, as a post-doctoral researcher at iThemba LABS (Laboratory for Accelerator Based Sciences) in Cape Town, South Africa, focuses on neutrons. These are subatomic particles that can penetrate through matter, which means they can be harnessed for all sorts of important work.

For example, high-energy neutrons may be used to destroy tough tumours that can’t be killed by the usual x-rays that are available in hospitals.

Continue reading “How African researchers are adding to deeper knowledge about neutrons” »

The treatment could transform the lives of five million in the UK who have the disease.

As promising as a drug candidate may be, the unfortunate truth is that not all of them end up performing as hoped – but that doesn’t mean they’re completely useless. Researchers at Oxford University have managed to give second life to an experimental cancer drug known as tasquinimod, which has now shown promise in preventing Parkinson’s.

December 1 is World AIDS Day, an annual event dedicated to raising awareness and money to fight AIDS around the world.

Over the last four decades, HIV and AIDS have been at the forefront of advocacy and research. But despite medical advances, AIDS remains one of the most destructive pandemics in history, particularly of youth.

HIV treatments have come a long way in the more than 30 years since the virus was first identified.

Powerful antiretroviral drugs (ARVs) can now keep the virus controlled at levels that current tests cannot detect in the blood. Perhaps just as important, people who take these drugs diligently soon after they’re infected are unlikely to pass the virus to others. But the treatment isn’t perfect. Those with HIV need to take a pill every day for the rest of their lives, and even if they do, the virus can easily morph to become resistant to the drugs. That’s why patients on ARV treatment should faithfully monitor their virus and cycle between different combinations of drugs.

Finding new, easier ways to more effectively treat HIV and stop its spread is therefore an urgent priority, and researchers are now looking beyond daily drugs to therapies that might provide people with more lasting protection.