Lifeboat Foundation

Aging is a battle that humans have known they can’t win since the beginning of history. We can hate it or (eventually) accept it but ultimately we can’t avoid growing old. However, over the years scientists have been trying to pinpoint the roots of this biological process and work out if there is any way to stop or reverse it. There have been some minor successes along the way and a new study adds to these.

The researchers were able to reverse the aging process of some old human cells by delivering a specific molecule to their mitochondria, the structures within cells where energy is produced. This approach stops the cells from becoming senescent, a point at which they can no longer duplicate. Some researchers believe that the accumulation of these cells in organs is key to the aging process.

“We still don’t fully understand why cells become senescent as we age, but damage to DNA, exposure to inflammation and damage to the protective molecules at the end of the chromosomes – the telomeres – have all been suggested,” the authors wrote in a post on The Conversation. “More recently, people have suggested that one driver of senescence may be loss of our ability to turn genes on and off at the right time and in the right place.”

Continue reading “Scientists Have Successfully Reversed The Aging Of Human Cells In The Lab” »

Shares in German chemicals and pharmaceuticals giant Bayer tumbled more than 10 percent as markets opened Monday, as investors reacted to a shock US ruling against freshly-acquired Monsanto.

Stock in the Leverkusen-based group fell 10.4 percent to 83.61 euros ($95.19) around 9:25 am (0725 GMT), after a California jury on Friday awarded a dying groundskeeper damages of almost $290 million, saying Monsanto should have warned buyers that its flagship Roundup weedkiller could cause cancer.

While observers have predicted thousands of other claims could follow, Bayer said the jury’s findings went against scientific evidence and that other courts might “arrive at different conclusions”.

To learn more about the conference and see more talks like this please visit us at: https://www.leafscience.org/ending-age-related-diseases-2018/

Barbra Streisand is not alone. At a South Korean laboratory, a once-disgraced doctor is replicating hundreds of deceased pets for the rich and famous. It’s made for more than a few questions of bioethics.

By

• David Ewing Duncan

Aging (Albany NY). 2018 Jul 19;10:1666–1681. doi: 10.18632/aging.101500.

Latorre E, Torregrossa R, Wood ME, Whiteman M, Harries LW.

1University of Exeter Medical School, University of Exeter, UK.2College of Life and Environmental Sciences, University of Exeter, UK.

#mTOR (mammalian target of rapamycin) Inhibiting TORC1 has been shown to increase lifespan.

Today, we are pleased to announce that the results are in from a human trial that targets the aging immune system and that an immune system-boosting drug appears to be effective.

Targeting TORC1 to boost the immune system

Continue reading “ResTORbio Announces Results in Phase 2b Human Trial” »

Denis Aabo Sørensen lost his left hand nine years ago, while handling fireworks. Since then, he has used prosthetic hands, but never one like this. Last year, a team of European engineers created for him a prosthetic hand that connects directly to the remaining nerves in his upper arm. That means the hand is able to send sensations of touch back through his arm and into his brain. Plus, when Sørensen wanted to grab something, he could move the hand by simply thinking about it.

By combining quantum mechanical quirks of light with a technique called photonic force microscopy, scientists can now probe detailed structures inside living cells like never before. This ability could bring into focus previously invisible processes and help biologists better understand how cells work.

Photonic force microscopy is similar to atomic force microscopy, where a fine-tipped needle is used to scan the surface of something extremely small such as DNA. Rather than a needle, researchers used extremely tiny fat granules about 300 nanometers in diameter to map out the flow of cytoplasm inside yeast cells with high precision.

To see where these miniscule fat particles were, they shined a laser on them. Here, the researchers had to rely on what’s known as squeezed light. Photons of light are inherently noisy and because of this, a laser beam’s light particles won’t all hit a detector at the same time. There is a slight randomness to their arrival that makes for a fuzzy picture. But squeezed light uses quantum mechanical tricks to reduce this noise and clear up the fuzziness.

Scientists have developed gene therapy that lets deaf mice hear whispers – and humans could be next.

An extreme form of inherited deafness has been cured in the rodents, which could pave the way for life-changing treatments for humans born with gene defects that affect hearing and balance.

In a groundbreaking experiment, scientists used a laboratory-made virus to deliver corrective DNA into the inner ear.

Continue reading “Revolutionary gene therapy could be a miracle cure for deafness” »