Lifeboat Foundation

An investigational drug in clinical trials for rheumatoid arthritis also prevents a common, life-threatening side effect of stem cell transplants, new research shows.

Studying mice, the researchers found the drug prevented what’s known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body’s own organs or tissues.

About half of patients receiving donor stem cells develop graft-versus-host disease, which can linger for months or years after their transplants. In some cases, patients die not from their cancer but from the complication itself. Current treatments are not effective.

Scientists at Wake Forest Baptist Medical Center and the University of Southern California (USC) have demonstrated the successful implementation of a prosthetic system that uses a person’s own memory patterns to facilitate the brain’s ability to encode and recall memory.

In the pilot study, published in today’s Journal of Neural Engineering, participants’ short-term memory performance showed a 35 to 37 percent improvement over baseline measurements. The research was funded by the U.S. Defense Advanced Research Projects Agency (DARPA).

Jeffrey Tibbetts prepped for implantation and scrubbed in, methodically sudsing up to his elbows, scraping the dirt from under his fingernails and scouring his hands with a rough brush to render his body sterile before donning a pair of beige latex surgical gloves.

Behind him, a twentysomething tea barista in a black baseball cap waited pensively, his left ring finger exposed from under a surgical drape, a tourniquet wrapped tightly around it. For months, an implanted magnet had been uncomfortably bulging out of the side of Zac Shannon’s finger. Tibbetts picked up a scalpel and began cutting, gently scraping away at the flesh until the incision was deep enough to expose the magnet. With the very steady hands of a practiced surgeon, he pulled out the tiny hunk of metal.

Tibbetts plopped another magnet into the finger, sutured it shut, and removed the tourniquet. The small wound began to gush blood.

Continue reading “I Spent a Weekend With Cyborgs, and Now I Have an RFID Implant I Have No Idea What to Do With” »

Experts have equipped biotech workhorse bacteria with feedback control mechanism to balance growth with making protein products.

Medicines like insulin and interferon are manufactured using genetically engineered bacteria, such as E. coli. E. coli grow quickly and can be given DNA that instructs them to make proteins used in medicines and other materials.

However, the extra burden of producing new proteins hampers bacterial growth, which slows production. Solving this problem is an area of great interest for biotechnology and synthetic biology.

Continue reading “E. coli rewired to control growth as experts let them make proteins for medicine” »

Whole genome sequencing is more precise than other methods, and it just keeps getting faster and cheaper. Joel Sevinsky, head of the Molecular Science Laboratory at the Colorado Department of Public Health and Environment (CDPHE), told the Associated Press his lab can sequence the genome of a suspected pathogen in less than 72 hours.

Whole genome sequencing is already helping researchers address food-borne outbreaks, including a 2017 salmonella outbreak that stretched across 21 states, and the current romaine outbreak.

Continue reading “You Know That Romaine-Linked Outbreak? DNA Tech Is Fixing It” »

The device can already detect antibodies for measles and rubella.

• By Helen Branswell, STAT on April 26, 2018

NIH-funded study closes in on personalized drug testing for neurological disorders.

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AI can discover new drugs because biology is messy and complex, not in spite of that fact, says Andrew Hopkins.

Today, we have a new study showing that a common, plant-based compound could help clear out unwanted senescent cells, which accumulate with age and produce inflammatory signals that drive age-related disease progression.

Taking out the trash

A new study has investigated a natural, plant-based compound for its ability to destroy senescent cells [1]. These cells accumulate with age due to the aging immune system becoming increasingly poor at removing them; this leads to a build-up of these cells and the secretions they produce, which cause chronic inflammation. These proinflammatory secretions are known as the senescence-associated secretory phenotype (SASP).

Continue reading “Goldenrod Extract has a Marginal Senolytic Effect in Cell Culture Study” »