Lifeboat Foundation

We are making good progress in identifying neural circuits in our brain, small areas responsible for the execution of specific tasks. It is not always the case, actually several tasks are involving many areas in different regions of the brain. Also in this case, however, specific regions host neural circuits whose activity spread around influencing other neural networks. The malfunctioning of these “networks” results in disabilities and the good news is that researchers are starting to find ways to restore (in some cases) the correct working of these neural circuits using drugs.

The problem, however, is that these drugs cannot be delivered through the blood vessels since they would reach “the whole brain” and what is good for a “faulty” circuit may be bad for a “good” circuit. Besides, many drugs cannot flow across the membrane separating the arteries and veins from the brain (the so called blood-brain barrier). This obstacle is exploited by new technologies based on ultrasound beams that can be focussed in a specific place of the brain resulting in the opening of the blood vessels membrane in that area thus letting the drug reach the neurones. This is great but in mot cases it is not enough because the area “flooded” by the drug is still quite large (on a neuronal scale).

Continue reading “Delivering right on the spot … in the brain” »

The International Papillomavirus Society has announced that Australia could become the first country to eliminate cervical cancer entirely.

According to a new study, Australia’s efforts to distribute a human papillomavirus (HPV) vaccine for free in schools have been a resounding success.

The sexually transmitted infection causes 99.9 percent of cases of cervical cancer.

Continue reading “Australia Is Set to Become The First Country to Completely Eliminate One Type of Cancer” »

Some cancer cells express some of the same genes that senescent cells do, so it makes sense that drugs that destroy senescent cells may also destroy cancer cells. This was what the researchers in this new study set out to test.

However, in this experiment, the researchers discovered that the chosen senolytic drugs were not effective at destroying cancer cells with senescence-associated gene expression. While cancer cells and senescent cells do share some common properties, they are also quite different at an epigenetic level.

The researchers did, however, demonstrate that a so-called “suicide gene therapy” that causes both senescent cells and cancer cells to kill themselves worked by targeting senescence-associated p16Ink4a. This approach is similar to that of SENS spin-off company Oisin Biotechnologies, which is using a suicide gene therapy to eliminate senescent cells.

Two pivotal conferences on the topic of “death” coming up!!

First at the INSERM Liliane Bettencourt School on March 16–18 will be “Death: From Cells to Societies — Aging, Dying, and Beyond” -

Then, April 11–13 at Harvard Medical School, will be “Defining Death: Organ transplantation and the 50-year legacy of the Harvard report on brain death”

Continue reading “Bioquark Inc. — Conferences on Death / Death Reversal — Ira Pastor” »

http://www.creativefuturism.com/bioengineering-superhumans-fact-not-fiction/

Frozen corpses could be brought back to life and made to look YOUNGER than when they died using stem cell injections, claims expert…

EXCLUSIVE: Dennis Kowalski, President of the Michigan-based Cryonics Institute, has claimed scientists could revive a frozen human corpse by using stem cells to help repair damaged cells.

Continue reading “Humans frozen” »

On the run up to Undoing Aging 2018, Nicola Bagalà from LEAF did an interview to learn a bit more about our foundation and the story of our involvement in life extension.

As our readers probably already know, from March 15 to March 17 this year, the Undoing Aging 2018 Conference will be held at the Umspannwerk Alexanderplatz in Berlin, Germany. The event is intended to bring together scientists working on repair-based therapies for aging as well as to give life sciences students—and anyone else who may be interested, really—an occasion to deepen their understanding of the current state of rejuvenation research.

Organised by the Forever Healthy Foundation and the SENS Research Foundation, the conference will feature eminent researchers among its many speakers, such as the director of the Wake Forest Institute for Regenerative Medicine, Dr. Anthony Atala; Dr. Kristen Fortney, who is an expert on computational drug discovery and aging biomarkers; Dr. Michael West, co-CEO of BioTime and founder of Geron Corporation; Dr. James Kirkland, a world-class expert on cellular senescence; and Dr. Vera Gorbunova, a pioneer of the comparative biology approach to the study of aging and co-director of the Rochester Aging Research Center. In addition to its scientific, educational, and networking value, UA2018 will no doubt greatly contribute to the popularisation of this area of research and help spread awareness, both about the problem represented by age-related diseases and the great opportunity we have to finally bring aging under comprehensive medical control within a relatively short time frame.

Continue reading “Undoing Aging With Michael Greve” »

The Pentagon is hoping to tap into the incredible survival techniques of some of nature’s hardiest creatures to ‘slow biological time’ on the battlefield.

DARPA’s new program, dubbed Biostasis, aims to develop ways to buy extra time for wounded soldiers between the moment of injury and first medical treatment.

Continue reading “DARPA’s new program is looking for ways to ‘slow biological time’” »

A research team composed of scientists from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) and IBM Research has produced a new synthetic molecule that can target and kill five multidrug-resistant bacteria. This synthetic polymer was found to be non-toxic and could enable entirely new classes of therapeutics to address the growing problem of antibiotic-resistant superbugs.

The synthetic molecules are called guanidinium-functionalized polycarbonates and were found to be both biodegradable and non-toxic to human cells. Essentially, the positively-charged synthetic polymer enters a living body and binds specifically to certain bacteria cells by homing in on a microbial membrane’s related negative charge. Once attached to the bacteria, the polymer crosses the cell membrane and triggers the solidification of proteins and DNA in the cell, killing the bacteria.