Lifeboat Foundation

Harvard University’s David Sinclair, world renowned for his anti-aging research, sees no limit on human life span and is collaborating on a clinical trial to evaluate the effectiveness of a new drug aimed at slowing the aging process…

“There is no maximum human life span,” says Sinclair, Ph.D., who is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. “Anyone who says that doesn’t know what they are talking about.”

Sinclair hopes to demonstrate what he has been researching, – and talking about, for the past 20 years – that aging is a disease, which can be treated.

Continue reading “Harvard’s David Sinclair Treats Aging as a Disease and Plans to Launch a Clinical Trial to Prove It” »

Summary: A new study didn’t find much of a difference between healthy low-carb and low-fat diets. The people on both diets lost about the same amount of excess weight. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]

Is cutting carbs or cutting fat is better? A new study published in the Journal of the American Medical Association, suggest that it may not matter much.

A team of researchers led by Christopher Gardner, a professor of medicine at the Stanford University School of Medicine, followed 609 overweight adults ages 18 to 50. The researchers put the study participants, consisting of equal numbers of men and women, on either a low-carb diet or low-fat diet for 12 months.

Summary: UCSF scientists discover a protein in young blood that rejuvenates an aging brain. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]

Scientists have long been searching for the factors in young blood that give it its rejuvenating powers to drug form for widespread public use.

A team of researchers led by Saul Villeda, Ph.D., an assistant professor of anatomy at UC San Francisco discovered a brain-rejuvenating enzyme that improved memory in adult mice when restored to youthful levels. The researchers say the new protein could lead to new therapies for maintaining the healthy brain function of humans.

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The Germany-born scientist, who arrived in the U.S. in 1962 and never left, was an opera-loving bon vivant who would have stood out in any field. His discovery of how proteins navigate the body provided a foundation for today’s research into treatments for cancer and myriad other diseases.

Credit: Hashem Al-Ghaili

In our weekly news roundup: researching immunity to CRISPR, this year’s flu season, the legal battle over frozen embryos, and more.

Ann Donnelly was utterly confused the first time she examined her protein. On all counts, it behaved like an enzyme—a protein catalyst that speeds up biological reactions in cells. One could argue that enzymes, sculpted by eons of evolution, make life possible.

There was just one problem: her protein wasn’t evolved. It wasn’t even “natural.” It was, in fact, a completely artificial construct made with random sequences of DNA—something that’s never existed in nature before.

Donnelly was looking at the first artificial enzyme. An artificial protein that, by all accounts, should not be able to play nice with the intricate web of biochemical components and reactions that support life.

Continue reading “Enzyme Designed Entirely From Scratch Opens a World of Biological Possibility” »

Lab-grown tumor tissue matched response of the patient’s tumor to cancer treatment.