Lifeboat Foundation

Researchers at Duke University have managed to create functional human muscle tissue using skin cells as the starting point[1]. This research builds on their previous work from 2015, when they grew the first functioning muscle tissue using cells obtained from muscle biopsies[2].

Being able to create muscle cells using non-muscle tissue opens the door for scientists to grow muscle cells in bulk, provides an easier path to genome editing and gene therapies, offers a supply for basic research studies, and could help create personalized models for rare muscle diseases, leading to better patient outcomes.

http://www.playboy.com/articles/dna-to-find-the-one

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The 2018 Undoing Aging Conference is focused on the cellular and molecular repair of age-related damage as the basis of therapies to bring aging under full medical control.

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Today’s vision of a smart home has more to do with what’s technologically possible than what people really need.

Thus the endless parade of internet-connected wine openers, water bottles, meat thermometers and refrigerators, and a dearth of automation that would clean and fold our laundry, pick up things around the house or assist aging people as their physical strength wanes.

Not that some tinkerers aren’t trying to come up with life-changing tools. The annual Consumer Electronics Show, which opened in Las Vegas on Tuesday, is a showcase of the latest innovations from big corporations and tiny startups. Some of these inventions could soon be useful to consumers. Others look outlandishly impractical — or maybe it’s too soon to tell.

Crowdsourcing the fight against drug-resistance infection.

Canadian doctors just reversed severe MS using stem cells.

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J147 is an experimental drug that has been shown to treat Alzheimer’s disease, and it also appears to reverse some aspects of aging. It is also poised to enter human clinical trials in the near future, although how it works has been somewhat of a puzzle.

A new study published in the journal Aging Cell has changed all that, and the results are quite intriguing[1]. Researchers at the Salk Institute have solved the mystery of how J147 works and why it makes old flies, mice, and cells more youthful.

Microsoft has built an AI tool that predicts the accuracy of CRISPR so that researchers can avoid making incorrect edits of DNA.

Missing the target: CRISPR uses two components: a cutting protein and a guide RNA that directs it to the part of a genome you want to cut. The guide RNA is about 20 letters long. Problem is, multiple sites in a genome can have the same series of letters, so CRISPR could snip the wrong section—known as an “off target” effect.

Why that matters: Off-target effects are one of the biggest safety concerns with CRISPR. Making incorrect cuts in a genome could, say, switch on a cancer-causing gene.

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