Lifeboat Foundation

Sometimes a drug intended for one purpose turns out to have other uses. Metformin, a treatment for type 2 diabetes, may prove effective in treating cancer.

Researchers are a step closer to figuring out how metformin may help prevent cancer.

Metformin is generally used to treat type 2 diabetes. The drug helps the body use insulin more effectively.

Continue reading “Inexpensive Diabetes Drug May Be New Weapon in War on Cancer” »

Senescent cell removal holds great potential but are all research approaches equal?

Some scientific commentary on senescent cell clearing (Senolytics) and the different approaches the research community is engaged in.

“Researchers are taking two broad approaches to cellular senescence at the present time. The first is to build therapies that can selectively destroy senescent cells, following the SENS rejuvenation model of periodic removal of damage. If the number of senescent cells is managed so as to keep that count low, then they will not cause further harm. This has the advantage of being straightforward and requiring little further research to put into practice. A range of demonstrated treatments and potential treatments already exist — gene therapies, immunotherapies, senolytic drugs, and so forth — and companies such as Oisin Biotechnologies and UNITY Biotechnology are bringing some of these technologies to the clinic.”

Continue reading “Can Cellular Senescence be Reversed in the Near Future, and is Reversal Desirable?” »

Synthetic biology meets senolytics at Lifespan.io

We are developing tools to help researchers accurately target and remove dysfunctional cells in the body that have entered a state called “senescence”, and thereby assist in restoring it to youthful functionality. Please subscribe, share, and fund our campaign today! ►Campaign Link: https://www.lifespan.io/campaigns/cellage-targeting-senescen…c-biology/ ►Subscribe: https://www.youtube.com/user/LifespanIO?sub_confirmation=1

Continue reading “CellAge: Senescent Cell Targeting Technology Video” »

Dr. Aubrey de Grey from the SENS Research Foundation was kind enough to talk in support of CellAge and their campaign on Lifespan.io

We are developing tools to help researchers accurately target and remove dysfunctional cells in the body that have entered a state called “senescence”, and thereby assist in restoring it to youthful functionality. Please subscribe, share, and fund our campaign today! ►Campaign Link: https://www.lifespan.io/campaigns/cellage-targeting-senescen…c-biology/ ►Subscribe: https://www.youtube.com/user/LifespanIO?sub_confirmation=1

Continue reading “CellAge: Dr. Aubrey de Grey Endorsement Video” »

Cellular senescence is a complicated process but here it is explained in a simple infographic. The removal of senescent cells (senolytics) is a very hot topic right now and it represents the arrival of the first of the SENS therapies.

CellAge is one of the companies engaged in senolytic research and they are running a campaign on Lifespan.io if you would like to learn more about them.

https://www.lifespan.io/campaigns/cellage-targeting-senescen…c-biology/

Continue reading “Senescent cells accumulate with age and gradually poison their neighboring cells and secrete signals that shut down your stem cells and reduce your ability to regenerate tissue” »

By removing senescent cells from culture prior to transplant.

Designing synthetic promoters for safe and precise targeting of dysfunctional “senescent” cells, with the aim of developing senolytic gene therapies to remove them.

Lilly announced today that CYRAMZA® (ramucirumab) has been approved by the Singapore Health Sciences Authority to treat people with advanced gastric cancer, whose cancer has progressed after prior chemotherapy. First country in ASEAN to approve the new biologic therapy that extends survival in patients with advanced stomach cancer after prior chemotherapy

CYRAMZA^® (ramucirumab) is now available to Singaporeans living with advanced gastric cancer. The drug gained approval by Singapore’s Health Science’s Authority (HSA) earlier this year, marking the first regulatory approval in ASEAN. CYRAMZA is already available to patients in Japan, Korea, Taiwan and Hong Kong.

Now that’s an idea; education for systems. I can see the online university advertisements now showing an autonomous car beeping and flashing its lights over the enjoyment of graduating.

What if I told you to tie your shoes, but you had no laces? Or to cook dinner, but you had no pots or pans.

There are certain tools we need to succeed, which we often don’t have access to or are held back by a gatekeeper.

Continue reading “Why Machines Should Go To The University of Google, School of Artificial Intelligence” »

Nice write on polymeric coatings as a material option consider when developing implants replicating a natural electrode charge without creating damage or disruptions. Author proposes such materials could be leveraged beyond their use today and expanded to include BMI implants. Definitely, will take a closer look at.

Jeff Hendricks Biotectix outlines how polymeric coatings can help improve the performance of medical and consumer electronic devices.