Lifeboat Foundation

Northwestern Medicine scientists have discovered for the first time that the rhythm of breathing creates electrical activity in the human brain that enhances emotional judgments and memory recall.

These effects on behavior depend critically on whether you inhale or exhale and whether you breathe through the nose or mouth.

In the study, individuals were able to identify a fearful face more quickly if they encountered the face when breathing in compared to breathing out. Individuals also were more likely to remember an object if they encountered it on the inhaled breath than the exhaled one. The effect disappeared if breathing was through the mouth.

The Goldilocks zone with telomere length is the key.

Ever since researchers connected the shortening of telomeres—the protective structures on the ends of chromosomes—to aging and disease, the race has been on to understand the factors that govern telomere length. Now, scientists at the Salk Institute have found that a balance of elongation and trimming in stem cells results in telomeres that are, as Goldilocks would say, not too short and not too long, but just right.

The finding, which appears in the December 5, 2016, issue of Nature Structural & Molecular Biology, deepens our understanding of stem cell biology and could help advance stem cell-based therapies, especially related to aging and regenerative medicine.

Continue reading “Scientists find that for stem cells to be healthy, telomere length has to be just right” »

Money makes the world go round, or so they say. Payments, investments, insurance and billions of transactions are the beating heart of a fractal economy, which echoes the messy complexity of natural systems, such as the growth of living organisms and the bouncing of atoms.

Financial systems are larger than the sum of their parts. The underlying rules that govern them might seem simple, but what surfaces is dynamic, chaotic and somehow self-organizing. And the blood that flows through this fractal heartbeat is data.

Today, 2.5 exabytes of data are being produced daily. That number is expected to grow to 44 zettabytes a day by 2020 (Source: GigaOm). This data, along with interconnectivity, correlation, predictive analytics and machine learning, provides the foundation for our AI-powered future.

Continue reading “Artificial intelligence and the evolution of the fractal economy” »

The fourth Lifespan.io campaign and CellAge are using synthetic biology to create an accurate aging biomarker for senescent cells and a new therapy for precision targeting of those problem cells. Senescent cells are one of the processes of aging and this could change the way we age.

Lifespan.io is proud to present our fourth rejuvenation biotechnology project!

Continue reading “CellAge: Targeting Senescent Cells With Synthetic Biology” »

In Brief

• By observing the transparent cells of roundworms, researchers have uncovered a link between lifespan and the natural cellular process of RNA splicing.
• This research could lead to new breakthroughs in anti-aging treatments that would allow humans to indefinitely keep ourselves healthy, stalling death for as long as possible.

Though aging seems like one of the most natural things, an affair common to all living creatures, the process is actually poorly understood by scientists. A new study detailed in Nature aims to shed light on the phenomenon as a research team led by the Harvard T.H. Chan School of Public Health has uncovered a relationship between lifespan and RNA splicing, a core function of cells that allows a single gene to produce a variety of proteins.

The researchers already knew that mutations in RNA splicing could lead to disease, but they wanted to find out if the act of splicing itself had an impact on the aging process. To find out, they designed experimental setups using the roundworm Caenorhabditis elegans, which show visible signs of aging during their short three-week lifespan.

Continue reading “A New Aging Discovery Could Allow Humans to Extend Their Lifespan” »

Hemophilia is a devastating genetic condition—without the ability to form blood clots, those who have it risk bleeding to death from even the slightest cut.

Infertile women have been offered new hope after scientists found that a common cancer drug triggers the development of new eggs, an outcome which was previously thought to be impossible.

In a discovery hailed as “astonishing”, researchers at the University of Edinburgh proved it is possible to reverse the clock and coax the ovaries back into a pre-pubescent state where they begin to produce new eggs.

Women are born with all their eggs, which is why conceiving becomes harder with age, because the eggs grow old, become damaged and eventually run out entirely.

Continue reading “Infertility breakthrough as cancer drug sparks growth of new eggs in ‘astonishing’ discovery” »

The full antiaging rejuvenation toolkit of the next few decades will consist of a range of different treatments, each targeting a different type of molecular damage in cells and tissues. Fightaging predicts the likely order of arrival of some of these therapies, based on what is presently going on in research, funding, and for-profit development.

1) Clearance of Senescent Cells

Everon Biosciences, Oisin Biotechnologies, SIWA Therapeutics, and UNITY Biotechnology are all forging ahead with various different approaches to the selective destruction of senescent cells. No doubt many groups within established Big Pharma entities are also taking a stab at this, more quietly, and with less press attention. UNITY Biotechnology has raised more than $100 million to date, demonstrating that there is broad enthusiasm for this approach to the treatment of aging and age-related disease.

Continue reading “Fight Aging predicts the sequence of arrival for meaningful antiaging therapies” »

A brand new type of HIV vaccine will move onto phase II clinical trials in 2017, after phase I trials showed that it was safe to use in humans.

The potential new vaccine will be tested on 600 people in North America, to see how well it can prevent them from getting the virus.

Before we get too excited, the phase I trials were only set up to show that the vaccine was tolerated well by the human body — they didn’t demonstrate if it actually works as a preventative treatment.

Continue reading “A First-of-Its-Kind HIV Vaccine Will Move to Phase II Trials in 2017” »