Lifeboat Foundation

A research team at the University of Washington has harnessed complex computational methods to design customized proteins that can self-assemble into 120-subunit “icosahedral” structures inside living cells—the biggest, self-booting, intracellular protein nanocages ever made. The breakthrough offers a potential solution to a pressing scientific challenge: how to safely and efficiently deliver to cells new and emerging biomedical treatments such as DNA vaccines and therapeutic interfering particles.

The work, funded by DARPA in a lead-up to the new INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program, “opens the door to a new generation of genetically programmable protein-based molecular machines,” the researchers report in this week’s issue of the journal Science. The research paper is available here: http://ow.ly/LW8F302tOp3

Anyone familiar with the role-playing games Dungeons and Dragons and Munchkin need only picture the 20-sided die to understand what an organic, icosahedral cargo container looks like—symmetrical, triangle-shaped panels folded evenly on each side. Unlike a die that can be held in your hand, however, these creations are the size of small viruses and are designed to interact with cells in the same way viruses might—that is, by delivering their caged contents into a cell, albeit in this case with positive, customizable outcomes. Also, whereas dice are produced in molds on a factory assembly line, these nanocages build themselves inside cells, following with atomic precision instructions written in genetic code.

I never get tired of hearing more information on this research.

A synthetic genetic circuit programmed into an attenuated Salmonella enterica subspecies can be used to systemically deliver an anti-tumor toxin into mice with cancer. The circuit allows the bacterial cells inside a tumor to synchronously self-destruct by lysis, releasing the toxin directly in the tumor.

Researchers at the University of California San Diego and the Massachusetts Institute of Technology (MIT) have come up with a strategy for using synthetic biology in therapeutics. The approach enables continual production and release of drugs at disease sites in mice while simultaneously limiting the size, over time, of the populations of bacteria engineered to produce the drugs.

Continue reading “Engineered bacteria deliver an anti cancer tumor toxin in mice before self-destructing” »

Hope; or at least I am hoping.

A novel gene-editing technique with potential to revolutionize cancer treatment has scientists in a race to test it on humans.

As the scientific journal Nature announced last week: “Chinese scientists to pioneer first human CRISPR trial.”

Continue reading “CRISPR against cancer” »

Two years after an operation to transplant nerve cells from his nose into his severed spinal cord, a Bulgarian man is walking again.

If computers think for themselves, should they have human rights?

Heart attack patients who were not expected to live are fit and healthy after scientists regenerated their hearts with stem cells in a ground-breaking trial which could help millions of people with heart failure.

The research is the first to show that scarring of heart muscle, associated with a heart attack can be reversed, a feat which doctors believed was impossible, and which could eventually end the need for transplants.

Scarring of the heart stops the organ pumping blood effectively and can lead to further attacks and sudden death.

Continue reading “Major breakthrough against heart failure after scientists use stem cells in ‘astonishing’ trial which could help millions” »

Her computer, Karin Strauss says, contains her “digital attic”—a place where she stores that published math paper she wrote in high school, and computer science schoolwork from college.

She’d like to preserve the stuff “as long as I live, at least,” says Strauss, 37. But computers must be replaced every few years, and each time she must copy the information over, “which is a little bit of a headache.”

It would be much better, she says, if she could store it in DNA—the stuff our genes are made of.

A new blood treatment developed by researchers in Greece reportedly has the power to reverse menopause, enabling post-menopausal women to release eggs once again.

None of this has been peer-reviewed as yet, but if the results can be verified by others in the scientific community, the treatment might allow women to have offspring later in life.

It could also provide a treatment for those suffering from early menopause, a condition that affects roughly 1 percent of all women.

Continue reading “A team of scientists says they’ve found a way to reverse menopause” »

Will we live longer lives in the future? According to Ray Kurzweil, it’s only a matter of time until technology begins successfully tackling age-related disease—and life expectancy grows longer and longer. At some point, technology will annually add more than a year to our life expectancy—allowing us to indefinitely increase lifespans, and perhaps eventually live as long as we want.

“We will get to a point where our longevity, our remaining life expectancy is moving on away from us. The sands of time will run in rather than run out,” Kurzweil says.

Continue reading “Ray Kurzweil Outlines the Coming Biomedical Revolution [Video]” »