Lifeboat Foundation

Engineers at the University of California San Diego have developed the first flexible wearable device capable of monitoring both biochemical and electric signals in the human body. The Chem-Phys patch records electrocardiogram (EKG) heart signals and tracks levels of lactate, a biochemical that is a marker of physical effort, in real time. The device can be worn on the chest and communicates wirelessly with a smartphone, smart watch or laptop. It could have a wide range of applications, from athletes monitoring their workouts to physicians monitoring patients with heart disease.

Nanoengineers and electrical engineers at the UC San Diego Center for Wearable Sensors worked together to build the device, which includes a flexible suite of sensors and a small electronic board. The device also can transmit the data from biochemical and electrical signals via Bluetooth.

Nanoengineering professor Joseph Wang and electrical engineering professor Patrick Mercier at the UC San Diego Jacobs School of Engineering led the project, with Wang’s team working on the patch’s sensors and chemistry, while Mercier’s team worked on the electronics and data transmission. They describe the Chem-Phys patch in the May 23 issue of Nature Communications.

May turn out to be the “fountain-of-youth gene,” say researchers.

University of Virginia School of Medicine have discovered that a gene called Oct4 — which scientific dogma insists is inactive in adults — actually plays a vital role in preventing ruptured atherosclerotic plaques inside blood vessels, the underlying cause of most heart attacks and strokes.

Continue reading “Gene helps prevent heart attack, stroke; may also block effects of aging” »

The visible impacts of depression and stress that can be seen in a person’s face—and contribute to shorter lives—can also be found in alterations in genetic activity, according to newly published research.

In a series of studies involving both C. elegans worms and human cohorts, researchers from the Indiana University School of Medicine and the Scripps Research Institute have identified a series of genes that may modulate the effects of good or bad mood and response to stress on lifespan. In particular, the research pointed to a gene known as ANK3 as playing a key role in affecting longevity. The research was published May 24, 2016 in the Nature Publishing Group journal Molecular Psychiatry, the top ranked journal in the field of psychiatry.

“We were looking for genes that might be at the interface between mood, stress and longevity”, said Alexander B. Niculescu III, M.D., Ph.D., professor of psychiatry and medical neuroscience at the IU School of Medicine. “We have found a series of genes involved in mood disorders and stress disorders which also seem to be involved in longevity.

Continue reading “Researchers identify genes linked to the effects of mood and stress on longevity” »

(Medical Xpress)—A large team of researchers from a host of research facilities across Japan has found some genetic variants in some cancer cells that lead to enhanced PD-L1 protein production—which results in increased protection against attacks by the immune system. In their paper published in the journal Nature, the team describes their sequencing study involving adult T-cell leukemia/lymphoma cases, what they found and the possibility that such variants could be used as identifying markers in cancer patients.

Prior studies have shown that an increase in the expression of the protein PD-L1 by cancer cells confers enhanced protection against attacks by the human immune system—PD-1 receptors on T cells bind with PD-L1 causing the immune cells to become unresponsive, preventing them from attacking tumors. In this new effort, the researchers conducted a genetic analysis of a particular type of cancer cell to learn more about the genetic process involved in causing an increase in expression of PD-L1.

The team conducted whole-genome sequencing on samples given by 49 adult patients suffering from leukemia or lymphoma, looking specifically for variations that might account for an increase in expression of PD-L1. In so doing, they found that variations such as duplications, inversions or translocations in 13 of the samples, representing 27 percent of those tested, existed on a certain part of chromosome 9, which prior research had found was the part of the genome responsible for the expression of PD-L1. They report that such alterations seemed to cut off the gene’s 3’ untranslated region of the protein and in some cases led to rearranging the gene’s open reading frame, which allowed more of the protein to be expressed.

Continue reading “Genetic variants isolated that lead to enhanced PD-L1 protein production in cancer cells” »

“The possibility to selectively activate genes using various engineered variants of the CRISPR-Cas9 system left many researchers questioning which of the available synthetic activating Cas9 proteins to use for their purposes. The main challenge was that all had been uniquely designed and tested in different settings; there was no side-by-side comparison of their relative potentials,” said George Church, Ph.D., who is Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University, leader of its Synthetic Biology Platform, and Professor of Genetics at Harvard Medical School. “We wanted to provide that side-by-side comparison to the biomedical research community.”

In a study published on 23 May in Nature Methods, the Wyss Institute team reports how it rigorously compared and ranked the most commonly used artificial Cas9 activators in different cell types from organisms including humans, mice and flies. The findings provide a valuable guide to researchers, allowing them to streamline their endeavors.

The team also included Wyss Core Faculty Member James Collins, Ph.D., who also is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at the Massachusetts Institute of Technology (MIT)’s Department of Biological Engineering and Norbert Perrimon, Ph.D., a Professor of Genetics at Harvard Medical School.

Continue reading “A Guide to CRISPR Gene Activation” »

Oct4, a gene, thought to be inactive in adults, may actually play a vital role in preventing heart attacks and strokes and could also delay some of the effects of ageing, scientists have found. They said the gene could also prove critical in the field of regenerative medicine.

Representative photo.

AR for plastic surgery.

ILLUSIO, the next generation in computer imaging for plastic surgery, will be presenting at the 2016 Virtual Reality Summit in Seoul, South Korea on June 22. The conference is expected to attract thousands of people interested in the latest applications for virtual reality and augmented reality.

ILLUSIO CEO Ethan Winner will present the Company’s use of augmented reality for plastic surgery imaging. ILLUSIO combines the latest in 3D augmented reality technology with real-time morphing animation, providing a platform for plastic surgeons and their patients to visually communicate.

Continue reading “ILLUSIO to Present at 2016 Virtual Reality Summit in Seoul, South Korea” »

More information on ANTs.

In the minuscule world of nanotechnology, big steps are rare. But a recent development has the potential to massively improve our lives: an engine measuring 200 billionths of a metre, which could power tiny robots to fight diseases in living cells.

Life itself is proof of the extreme effectiveness of nanotechnology — the manipulation of matter on a molecular or atomic scale — in which DNA, proteins and enzymes can all be considered as machinery. In fact, researchers have managed to make micro-propellers using tiny strands of DNA. These strands can be stitched together so freely and precisely that the practise is known as “DNA origami”. However, DNA origami lacks force and operational speed (it takes time measurable in seconds), reducing its robotic function.

Continue reading “Powering nanotechnology with the world’s smallest engine” »

US biochemical engineer Frances Arnold on Tuesday won a million-euro technology prize in Finland for her work on “directed evolution”, a method of rewriting DNA to improve medicines and develop green fuels.

“Frances Arnold receives the 2016 Millennium Technology Prize in recognition of her discoveries that launched the field of ‘directed evolution’, which mimics natural evolution to create new and better proteins in the laboratory,” the Technology Academy Finland, which awards the prize at two-year intervals, said in a statement.

Arnold, 59, who is a professor of chemical engineering at California Institute of Technology, said her work made it possible to “solve human problems”, such as replacing toxic chemicals like fossil fuels.