Lifeboat Foundation

Very cool!

As we age, tiny blood vessels in the brain stiffen and sometimes rupture, causing “microbleeds.” This damage has been associated with neurodegenerative diseases and cognitive decline, but whether the brain can naturally repair itself beyond growing new blood-vessel tissue has been unknown. A zebrafish study published on May 3 in Immunity describes for the first time how white blood cells called macrophages can grab the broken ends of a blood vessel and stick them back together.

“Microbleeding occurs very often in the human brain, particularly in elderly people,” says Lingfei Luo, a developmental geneticist at Southwest University in China. “We believe that this macrophage behavior is the major cellular mechanism to repair ruptures of blood vessels and avoid microbleeding in the brain.”

To simulate a human brain microbleed, Luo and his colleagues shot lasers into the brains of live zebrafish to rupture small blood vessels, creating a clean split in the tissue with two broken ends. Then, the researchers used a specialized microscope to watch what happened next.

Cambridge’s new nano-scale light-powered piston engine that may one day energize devices to treat diseases directly or deliver drugs.

At the University of Cambridge researchers have developed a nano-scale light-powered piston engine that may one day energize devices to treat diseases directly or deliver drugs in powerful new ways. The device consists of charged gold nanoparticles within a polymer that bends and relaxes in response to heat changes. The polymer absorbs water when cooled, expanding in size, while heating the gold nanoparticles using a laser raises the temperature of the polymer, shedding the absorbed water and relaxing in response. This process happens in a fraction of a second, and as long as a laser is made to flip between being on and off, the engine keeps working.

According to the researchers, the force generated given the weight of the device is quite huge, at least a hundred times greater than existing motors or even muscle cells.

Continue reading “Scientists Develop Powerful Bio-Compatible Nano-Motor” »

A groundbreaking trial to see if it is possible to regenerate the brains of dead people, has won approval from health watchdogs.

A biotech company in the US has been granted ethical permission to recruit 20 patients who have been declared clinically dead from a traumatic brain injury, to test whether parts of their central nervous system can be brought back to life.

Scientists will use a combination of therapies, which include injecting the brain with stem cells and a cocktail of peptides, as well as deploying lasers and nerve stimulation techniques which have been shown to bring patients out of comas.

Continue reading “Dead could be brought ‘back to life’ in groundbreaking project” »

Nanomachines could revolutionize technology and modern medicine, if only we had viable power sources to make them move where we wanted them to go. Now scientists at the University of Cambridge have built the world’s tiniest engines, powered by light, as described in a new paper in the Proceedings of the National Academy of Sciences.

Dubbed “ANTs” (for actuating nano transducers), these itsy-bitsy devices could one day realize the vision of the 1966 classic film Fantastic Voyage, in which a miniaturized submarine crew travel through the body of an injured scientist to repair a blood clot in his brain—except there would be no need for shrunken human pilots. Like real ants, these nano engines can produce very large forces relative to their weight, according to lead researcher Jeremy Baumberg.

It works a bit like a spring mechanism. At the heart of the device are lots of charged gold nanoparticles, held together by a polymer gel that responds to changes in temperature. The gel is heated by zapping it with a laser. The polymer gel responds by expelling all its water in a fraction of a second and collapsing, much like coiling a spring. This stores elastic energy as the gold nanoparticles are smushed together into tight clusters.

Continue reading “The World’s Tiniest Light-Powered Engines Could Revolutionize Medicine” »

When tweaking its architecture, the adult brain works like a sculptor—starting with more than it needs so it can carve away the excess to achieve the perfect design. That’s the conclusion of a new study that tracked developing cells in an adult mouse brain in real time.

New brain cells began with a period of overgrowth, sending out a plethora of neuronal branches, before the brain pruned back the connections. The observation, described May 2, 2016 in Nature Neuroscience, suggests that new cells in the adult brain have more in common with those in the embryonic brain than scientists previously thought and could have implications for understanding diseases including autism, intellectual disabilities and schizophrenia.

“We were surprised by the extent of the pruning we saw,” says senior author Rusty Gage, a professor in Salk’s Laboratory of Genetics and holder of the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease.

A new analysis indicates that a type of psychotherapy delivered by videoconference may help prevent some of the long-term memory issues caused by chemotherapy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings point to a noninvasive way to help cancer survivors manage some of the negative effects of their treatment.

It’s estimated that approximately half of cancer patients who receive chemotherapy develop long-lasting changes in memory function such as trouble remembering conversational content or steps in a task. While the memory problems tend to be mild, they diminish quality of life in areas of job performance and family and social life well beyond cancer treatment. The causes of this problem and reasons why it does not affect every survivor remain unknown, and there is currently limited research on treatments for it.

A team led by Robert Ferguson, PhD, who is currently at the University of Pittsburgh Cancer Institute but was at the Eastern Maine Medical Center and Lafayette Family Cancer Center in Bangor, Maine, while conducting this research, developed a cognitive-behavioral therapy called “Memory and Attention Adaptation Training” (MAAT), which helps cancer survivors to increase awareness of situations where memory problems can arise and to develop skills to either prevent memory failure or to compensate for memory dysfunction.

Silicon Valley’s newest valley member; wonder if Google or eBay will send a “Welcome Basket” to the FDA?

Helmy Eltoukhy’s company is on a roll. The start-up is a leading contender in the crowded field of firms working on “liquid biopsy” tests that aim to be able to tell in a single blood draw whether a person has cancer.

Venture investors are backing Guardant Health to the tune of nearly $200 million. Leading medical centers are testing its technology. And earlier this month, it presented promising data on how well its screening tool, which works by scanning for tiny DNA fragments shed by dying tumor cells, worked on an initial group of 10,000 patients with late-stage cancers.

Continue reading “FDA new sheriff in town in Silicon Valley” »

What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism? I’m guessing you’d be like: surprised .

So, here’s the deal. My biohacker friends led by Peter Fedichev and Sergey Filonov in collaboration with my old friend and the longevity record holder Robert Shmookler Reis published a very cool paper. They proposed a way to quantitatively describe the two types of aging – negligible senescence and normal aging. We all know that some animals just don’t care about time passing by. Their mortality doesn’t increase with age. Such negligibly senescent species include the notorious naked mole rat and a bunch of other critters like certain turtles and clams to name a few. So the paper explains what it is exactly that makes these animals age so slowly – it’s the stability of their gene networks.

What does network stability mean then? Well, it’s actually pretty straightforward – if the DNA repair mechanisms are very efficient and the connectivity of the network is low enough, then this network is stable. So, normally aging species, such as ourselves, have unstable networks. This is a major bummer by all means. But! There is a way to overcome this problem, according to the proposed math model.

Continue reading “10 responses to ‘Hacking Aging’” »

A study performed at IRB Barcelona offers an explanation as to why the genetic code stopped growing 3,000 million years ago. This is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins. The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life. The discovery could have applications in synthetic biology.

Nature is constantly evolving—its limits determined only by variations that threaten the viability of species. Research into the origin and expansion of the genetic code are fundamental to explain the evolution of life. In Science Advances, a team of biologists specialised in this field explain a limitation that put the brakes on the further development of the genetic code, which is the universal set of rules that all organisms on Earth use to translate genetic sequences of nucleic acids (DNA and RNA) into the amino acid sequences that comprise the proteins that undertake cell functions.

Headed by ICREA researcher Lluís Ribas de Pouplana at the Institute for Research in Biomedicine (IRB Barcelona) and in collaboration with Fyodor A. Kondrashov, at the Centre for Genomic Regulation (CRG) and Modesto Orozco, from IRB Barcelona, the team of scientists has demonstrated that the genetic code evolved to include a maximum of 20 amino acids and that it was unable to grow further because of a functional limitation of transfer RNAs—the molecules that serve as interpreters between the language of genes and that of proteins. This halt in the increase in the complexity of life happened more than 3,000 million years ago, before the separate evolution of bacteria, eukaryotes and archaebacteria, as all organisms use the same code to produce proteins from genetic information.

Continue reading “Discovery of a fundamental limit to the evolution of the genetic code” »