Lifeboat Foundation

Genetic transcription is a data problem, and AI is on the case.

Study finds measuring levels of a protein could be just as good at detecting disease as lumbar punctures.

Three years old boy with reassuring development had presented to the Pediatric Neurology clinic with a referral due to a large head. Occipito-frontal circumference was more than 97th centile with an unremarkable neurological examination. MRI brain exhibited an acute on chronic large right frontoparietal subdural hematoma with prominent mass effect. Consequentially, the hematoma was evacuated by the neurosurgeon. Postoperative recovery stayed satisfactory. Hematology workup showed normal coagulation and clotting factors levels. Whole exome sequencing (WES) study revealed heterozygous variant c.5187G>A p.(Trp1729• in gene FBN1 — pathogenic for Marfan syndrome. However, this variant has not yet been reported in association with cerebral arteritis/intracerebral bleed. On follow-up, the child remained asymptomatic clinically with static head size.

By Chuck Brooks

Computing paradigms as we know them will exponentially change when artificial intelligence is combined with classical, biological, chemical, and quantum computing. Artificial intelligence might guide and enhance quantum computing, run in a 5G or 6G environment, facilitate the Internet of Things, and stimulate materials science, biotech, genomics, and the metaverse.

Computers that can execute more than a quadrillion calculations per second should be available within the next ten years. We will also rely on clever computing software solutions to automate knowledge labor. Artificial intelligence technologies that improve cognitive performance across all envisioned industry verticals will support our future computing.

Continue reading “Computational Capabilities That Will Transform the World” »

The new virus is thought to eliminate dormant bacteria, providing significant hope against the predicted 10 million annual deaths expected by 2050.

When bacteria encounter a lack of nutrients or experience stress induced by the antibiotics, they undergo a regulated shutdown of their metabolism, entering a dormant resting state.

This ETH Zurich-led discovery significantly advances addressing the global superbug crisis.

Continue reading “Researchers discover new virus warrior slaying deadly superbug in sleep” »

See why new discoveries about water on Mars and water on the Moon are great news for the future of space settlement!

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The study hypothesizes that ‘pre-digested’ foods contributed to the development of larger brains. The large, capable human brain is a marvel of evolution, but how it evolved from a smaller primate brain into the creative, complex organ of today is a mystery. Scientists can pinpoint when our evolutionary ancestors evolved larger brains, which roughly tripled in size as human ancestors evolved from the bipedal primates known as Australopithecines.

Short, toxic RNAs kill brain cells and may allow Alzheimer’s to develop.

Cedars-Sinai Cancer investigators have used a unique precision medicine and artificial intelligence (AI) tool called the Molecular Twin Precision Oncology Platform to identify biomarkers that outperform the standard test for predicting pancreatic cancer survival. Their study, published in Nature Cancer, demonstrates the viability of a tool that could one day guide and improve treatment for all cancer patients.

“Molecular Twin, which we developed at Cedars-Sinai, can be used to study any tumor type, including pancreatic cancer, which is notoriously difficult to treat,” said Dan Theodorescu, MD, Ph.D., director of Cedars-Sinai Cancer and the PHASE ONE Foundation Distinguished Chair, and senior author of the study. “Using our Molecular Twin technology, we anticipate creating tests that can be used even in locations that lack access to advanced resources and technology, pairing patients with the most effective therapies and expanding the availability of precision medicine.”

Investigators used the Molecular Twin platform to analyze blood and tissue samples from 74 patients with the most common and most aggressive pancreatic cancer type, pancreatic ductal adenocarcinoma. The disease begins in the cells lining ducts that carry digestive enzymes from the pancreas to the small intestine.