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Scientists develop anticancer drugs that target PARP proteins involved in the DNA damage response.

Why are so many young people getting cancer?

Here’s what the data say:

Clues to a modern mystery could be lurking in information collected generations ago.

Nanomedicine to Cure All!

Aortic aneurysms are bulges in the aorta, the largest blood vessel that carries oxygen-rich blood from the heart to the rest of the body. Smoking, high blood pressure, diabetes, or injury can all increase the risk of aneurysms, which tend to occur more often in Caucasian male smokers over the age of 65.

“The soft tissues that make up blood vessels act essentially like rubber bands, and it’s the elastic fibers within these tissues that allow them to stretch and snap back,” says Professor Anand Ramamurthi, chair of the Department of Bioengineering in Lehigh University’s P.C. Rossin College of Engineering and Applied Science. “These fibers are produced primarily before and just after birth. After that, they don’t regenerate or undergo natural repair after injury. So when they become injured or diseased, the tissue weakens and causes an aneurysm, which can grow over time. After about seven to 10 years, it typically reaches the rupture stage.”

Continue reading “Nanomedicine research aims to transform treatment of aortic aneurysms” »

Cerebral cavernous malformations occur in 0.5% of the population; 85% are sporadic, and 15% are familial or radiation-induced. Several genetic variants, including variants in CCM, drive their development. Read the full review:

Review Article from The New England Journal of Medicine — Cavernous Malformations of the Central Nervous System.

Here are 10 signs to look for if you suspect a loved one may have Alzheimer’s disease:

If you suspect a loved one may have Alzheimer’s disease, here are 10 signs to look for from WebMD.

Discover a fascinating case study on Superficial Temporal Artery-to-Middle Cerebral Artery Bypass for Ischemic Stroke with Blood Pressure-Dependent Symptoms! 🧠

Tap the link to discover:

The efficacy of extracranial-intracranial (EC-IC) bypass in preventing ischemic stroke progression and recurrence is controversial. As per the current hypothesis, EC-IC bypass is most beneficial for patients with persistent hemodynamic insufficiency. Hence, various approaches have been used to evaluate hemodynamic insufficiency, including repeated single photon emission CT (SPECT) imaging or continuous monitoring of cerebral flow with transcranial Doppler ultrasound (TCD). However, both modalities are time-and resource-intensive. In this report, we discuss how EC-IC bypass turned out to be beneficial for a patient presenting with blood pressure-dependent severe aphasia and right hemiparesis due to middle cerebral artery (MCA) occlusion that failed thrombectomy. CT perfusion (CTP) scan at admission demonstrated a persistent volume of delayed perfusion without core infarct.

Continue reading “Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms” »

Multiresolution computational simulations generate all-atom models of a complete packaged virus particle.

The blockbuster weight loss drug semaglutide can cut the progression of diabetic kidney disease, according to its manufacturer Novo Nordisk, adding to growing evidence that the medication has beneficial effects beyond treating Type 2 Diabetes and obesity.

Semaglutide — which is marketed under the name Ozempic for diabetes treatment and Wegovy for weight loss — managed to also reduce death from kidney disease and cardiovascular issues by 24 percent versus a placebo.

The results came from a Novo Nordisk clinical trial that had 3,533 participants with both diabetes and chronic kidney disease. High blood sugar from diabetes can damage kidneys and ultimately lead to chronic kidney disease, in which the organ has trouble filtering toxins from the blood.

Year 2023 face_with_colon_three

More than half a billion people worldwide are affected by type 2 diabetes, and yet researchers still don’t know what’s behind the condition’s breakdown in insulin functionality.

Researchers from Case Western Reserve University in the US have now pulled back the molecular curtain and figured out why insulin, the hormone that maintains stable blood sugar, often stops working at its full effect.

Continue reading “Scientists Think They’ve Found a New Cause of Type 2 Diabetes” »