Lifeboat Foundation

Although artificial skins can facilitate the healing of damaged skin, the restoration of tactile functions remain a challenge. Here, Kang et al. report an artificial skin with an implantable tactile sensor that can simultaneously replace the tactile function by nerve stimulation and promote skin regeneration.

Unlike older methods that use things foreign to our bodies, this one doesn’t trigger our immune system and employs small molecules to interact with RNA.

Researchers at Baylor College of Medicine have developed a breakthrough technology to regulate gene expression in gene therapy, addressing the crucial issue of maintaining therapeutic gene levels within a safe range.

This is important because having too much or too little of a gene’s activity within a therapeutic window can cause problems. Their method uses tiny substances in amounts approved by the FDA to control the genes.

Continue reading “Gene on/off? New tech lets scientists control genes like a light switch” »

Diets that are higher in fat and significantly lower in carbohydrates are known to have a drastic effect on reducing the incidence of seizures in individuals with drug-resistant forms of epilepsy, particularly among children.

While it’s becoming apparent the diet creates some sort of shift in the gut’s microflora, the precise nature of those changes and their connection to the prevalence of seizures remains a mystery.

In a prospective study on children and experiments involving mice, researchers from the University of California, Los Angeles (UCLA) bring us a step closer to understanding how the foods we eat alter the functions of microbes in our digestive system, which in turn affect a variety of neurological functions suspected to play a role in epilepsy.

Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell. These subcellular structures carry out specific jobs within the cell; for example, mitochondria power the cell, and lysosomes keep the cell tidy.

Although damage to these two organelles has been linked to aging, cellular senescence, and many diseases, the regulation and maintenance of these organelles have remained poorly understood. Now, researchers at Osaka University have identified a protein, HKDC1, that plays a key role in maintaining these two organelles, thereby acting to prevent cellular aging.

There was evidence that a protein called TFEB is involved in maintaining the function of both organelles, but no targets of this protein were known. By comparing all the genes of the cell that are active under particular conditions and by using a method called chromatin immunoprecipitation, which can identify the DNA targets of proteins, the team was the first to show that the gene encoding HKDC1 is a direct target of TFEB, and that HKDC1 becomes upregulated under conditions of mitochondrial or lysosomal stress.

Memorial Sloan Kettering Cancer Center (MSK) has spearheaded revolutionary research unveiling groundbreaking strides in cancer treatment and understanding disease mechanisms.

Their discoveries include CAR T cell therapy targeting specific antigens in acute myeloid leukemia (AML), insights into the genetic element LINE-1, revelations on blood stem cell regulation, and a promising immunotherapy technique targeting CD47, showcasing potential breakthroughs in cancer therapy.

In the battle against acute myeloid leukemia (AML), traditional CAR T cell therapies faced hurdles due to varying antigens in AML cells and their similarity to normal blood stem cells, risking broader immune system damage.

Sunlight provides so much more than just Vitamin D: learn from Dr. Seheult of https://bit.ly/44MTKR2 about the myriad of benefits from optimizing our exposure to light.

Roger Seheult, MD is the co-founder and lead professor at https://bit.ly/44MTKR2

Continue reading “Boost Health and Immunity with Sunlight: Light Therapy and Melatonin” »

I believe nanomachines or new advanced rna antivirals that can target one’s own variants of viruses will be game changers to prevent future global pandemics. Also eventually new genetic engineering could allow for the end to all viruses with some sorta Omni vaccine.

Measurement(s) Pandemic-and epidemic-prone disease outbreaks Technology Type(s) Text mining using R Sample Characteristic — Organism Disease outbreaks Sample Characteristic — Environment spatiotemporal region Sample Characteristic — Location Global.

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New vaccine may protect against future variants of coronaviruses, such as COVID-19 and SARS.

Cankat, S., Demael, M.U. & Swadling, L. In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms. Cell Mol Immunol (2023). https://doi.org/10.1038/s41423-023-01116-8

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