Lifeboat Foundation

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then hold those antibodies in abeyance in case they encounter that same pathogen again, the way we do. Instead, they incorporate some of the pathogen’s DNA into their own genome and link it to an enzyme that can use it to recognize that pathogenic DNA sequence and cut it to pieces if the pathogen ever turns up again.

The enzyme that does the cutting is called Cas, for CRISPR associated. Although the CRISPR-Cas system evolved as a bacterial defense mechanism, it has been harnessed and adapted by researchers as a powerful tool for genetic manipulation in laboratory studies. It also has demonstrated agricultural uses, and the first CRISPR-based therapy was just approved in the UK to treat sickle-cell disease and transfusion-dependent beta-thalassemia.

Now, researchers have developed a new way to search genomes for CRISPR-Cas-like systems. And they’ve found that we may have a lot of additional tools to work with.

A new study in mice, published recently in the journal Cell Metabolism, shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.

There’s a popular saying in some circles that “a calorie is a calorie,” but science shows that it may not be true. In fact, it may be possible to eat more of some kinds of calories while also improving your health.

“We like to say a calorie is not just a calorie,” says Dudley Lamming, a professor and metabolism researcher at the University of Wisconsin School of Medicine and Public Health. “Different components of your diet have value and impact beyond their function as a calorie, and we’ve been digging in on one component that many people may be eating too much of.”

Beyond glycemic benefits, users of the app also reported significantly less-related emotional distress than standard care (−1.9 vs 1.7 points in composite survey scores, P =0.03).

“We are currently working on making technology like this accessible to patients outside of research settings because we think it can really help patients in underserved areas who need high-touch care to get their under control,” Nayak said.

The researchers developed their custom voice-based AI app and had it powered by Alexa (Amazon wasn’t involved with the study). The software was equipped with titration algorithms by the American Association of Clinical Endocrinologists and the American College of Endocrinology and included emergency protocols to handle hypoglycemia and hyperglycemia.

The field of research focusing on self-propelled particles, known as active particles, is rapidly expanding. In most theoretical models, these particles are assumed to maintain a constant swimming speed. However, this assumption does not hold true for many experimentally produced particles, like those propelled by ultrasound for medical applications. Their propulsion speed varies with orientation.

A team of physicists, led by Prof. Raphael Wittkowski from the University of Münster and including Prof. Michael Cates from the University of Cambridge, conducted a collaborative study to explore how this orientation-dependent speed influences the behavior of particle systems, particularly in cluster formation.

They combined computer simulations with theoretical analysis to uncover new effects in systems of active particles with orientation-dependent speeds. Their findings were recently published in the journal Physical Review Letters.

Chronic hepatitis B affects more than 250 million individuals worldwide, putting them at risk of developing liver cirrhosis and liver cancer. While antiviral immune responses are key to eliminating hepatitis B virus (HBV) infections, insufficient antiviral immunity characterized by failure to eliminate HBV-infected hepatocytes is associated with chronic hepatitis B. Prophylactic vaccination against hepatitis B successfully established protective immunity against infection with the hepatitis B virus and has been instrumental in controlling hepatitis B. However, prophylactic vaccination schemes have not been successful in mounting protective immunity to eliminate HBV infections in patients with chronic hepatitis B.

Painless lesions investigated in mice

Now, for the first time, researchers have looked into the lesions on mouse skin to assess if there are any metabolic signalling pathways that are responsible for thwarting pain. The aim is to hopefully use this mechanism to help people suffering from debilitating pain through the development of non-narcotic pain medications.

“No one knows why these lesions are painless – but it has been thought that the parasite somehow manipulates the host physiological system,” said Abhay Satoskar, senior author of the study and professor of pathology in The Ohio State University College of Medicine.

Researchers have worked out how a protein called photolyase repairs DNA using light, and their discoveries could guide the development of light-based manufacturing technologies.

By Grace Wade

This can be helpful for first responders in treating victims and patients with traumatic brain injury.

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How EyeD works?

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Researchers have found that some pathogens can use physical force to enter and survive inside cells, bypassing the immune system. This could lead to new ways of fighting intracellular infections.

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Toxoplasma as intracellular pathogen.

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