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EPFL scientists have crafted a biological system that mimics an electronic bandpass filter, a novel sensor that could revolutionize self-regulated biological mechanisms in synthetic biology.

Synthetic biology holds the promise of enhancing and modifying biological systems into innumerable new technologies for the benefit of society. This engineering approach to biology has already reaped benefits in the fields of drug delivery, agriculture, and energy production.

In a paper published in Nature Chemical Biology, EPFL researchers at the Laboratory of Protein Design and Immunoengineering (LPDI) at the School of Engineering have taken an important step in designing more performative biological systems.

As we learned in middle school science classes, inside this common variety of greens—and most other plants—are intricate circuits of biological machinery that perform the task of converting sunlight into usable energy. Or photosynthesis. These processes keep plants alive. Boston University researchers have a vision for how they could also be harnessed into programmable units that would enable scientists to construct the first practical quantum computer.

A quantum computer would be able to perform calculations much faster than the classical computers that we use today. The laptop sitting on your desk is built on units that can represent 0 or 1, but never both or a combination of those states at the same time. While a classical computer can run only one analysis at a time, a quantum computer could run a billion or more versions of the same equation at the same time, increasing the ability of computers to better model extremely complex systems—like weather patterns or how cancer will spread through tissue—and speeding up how quickly huge datasets can be analyzed.

The idea of using photosynthetic molecules from, say, a spinach leaf to power quantum computing services might sound like science fiction. It’s not. It is “on the fringe of possibilities,” says David Coker, a College of Arts & Sciences professor of chemistry and a College of Engineering professor of materials science and engineering. Coker and collaborators at BU and Princeton University are using computer simulations and experiments to provide proof-of-concepts that photosynthetic circuits could unlock new technological capabilities. Their work is showing promising early results.

Abrain is nothing if not communicative. Neurons are the chatterboxes of this conversational organ, and they speak with one another by exchanging pulses of electricity using chemical messengers called neurotransmitters. By repeating this process billions of times per second, a brain converts clusters of chemicals into coordinated actions, memories, and thoughts.

Researchers study how the brain works by eavesdropping on that chemical conversation. But neurons talk so loudly and often that if there are other, quieter voices, it might be hard to hear them.

Researchers from the Faculty of Medicine and Surgery at the Catholic University, Rome and the Fondazione Policlinico Universitario A. Gemelli IRCCS have developed an engineered protein that boosts memory.

Neuroscientists at the Faculty of Medicine and Surgery of the Catholic University, Rome, and the Fondazione Policlinico Universitario Agostino Gemelli IRCCS have genetically modified a molecule, the protein LIMK1, which is normally active in the brain, with a key role in memory.

They added a “molecular switch” that is activated by administering a drug, rapamycin, known for its several anti-aging effects on the brain.

Misaligned AI is not the one you should worry most about (yet).

For the first time, scientists have used the concept of evolutionary traps on human societies at large. They find that humankind risks getting stuck in 14 evolutionary dead ends, ranging from global climate tipping points to misaligned artificial intelligence, chemical pollution, and accelerating infectious diseases.

The anthropocene era: success and challenges.

A new device that can be swallowed like a pill can track vital signs such as breathing and heart rate from inside the body.

Left: Ben Pless Right: Traverso Lab at Brigham and Women’s Hospital.

“This device can help diagnose and monitor many health conditions without requiring hospital visits, which can make healthcare more accessible and supportive for patients,” says Giovanni Traverso, the lead author of the study, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital.

Continue reading “Swallowable device tracking vital signs inside the body in human trial” »

Now, generative AI models — similar to the large language model (LLM) that powers ChatGPT — are being developed to understand the rules and relationships of DNA, RNA and proteins, and the many functions and properties they produce.

How it works: Humans arrange the 26 letters in the modern English alphabet into roughly — and arguably — about 500,000 words.

Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress without symptoms, so diagnosis is usually very late.

Another problem: Advanced tumors – and their metastases – can no longer be completely removed. Chemotherapies, in turn, attack not only the tumor cells but also healthy cells throughout the body. Innovative nanoparticles could be a new approach to treat cancer more precisely.

The approach was developed by a research team from the Max Planck Institute (MPI) for Multidisciplinary Sciences, the University Medical Center Göttingen (UMG), and the Karlsruhe Institute of Technology (KIT). The therapy is now to be optimized for clinical application as quickly as possible.

Melting a bacteriophage’s coat of proteins turns it into a tiny power plant, which could fire up the discovery of new bioengineered devices.