Lifeboat Foundation

The software could cut delays in diagnosis and offer the “ultimate second opinion”, researchers have said.

Elucidating human contact networks could help predict and prevent the transmission of SARS-CoV-2 and future pandemic threats. A new study from Scripps Research scientists and collaborators points to which public health protocols worked to mitigate the spread of COVID-19—and which ones didn’t.

In the study, published online in Cell on December 14, 2023, the Scripps Research-led team of scientists investigated the efficacy of different mandates—including stay-at-home measures, social distancing and travel restrictions —at preventing local and regional transmission during different phases of the COVID-19 pandemic.

They found that local transmission was driven by the amount of travel between locations, not by how geographically nearby they were. The study also revealed that the partial closure of the U.S.-Mexico border was ineffective at preventing cross-border transmission of the virus. These findings, in combination with ongoing genomic surveillance, could help guide public health policy to prevent future pandemics and mitigate the new “endemic” phase of COVID-19.

Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only stimulate a two-pronged immune system response that enhances the body’s ability to fight cancer but also make vaccines more effective in targeting tumors.

“This research marks a pivotal turning point in our understanding of how lipid nanoparticles can be harnessed to optimize anticancer immunity,” said Hai-Quan Mao, director of Johns Hopkins’ Institute for NanoBioTechnology and professor in the Whiting School of Engineering’s Department of Materials Science and Engineering. “Our findings unlock new avenues for enhancing the efficacy of RNA-based treatments for cancer and infectious diseases.”

The team’s results appear in Nature Biomedical Engineering.

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai have introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain and loss-of-function variants across the genome.

Unlike current methods that predominantly focus on loss of function, LoGoFunc distinguishes among different types of harmful mutations, offering potentially valuable insights into diverse disease outcomes. The findings are described in Genome Medicine.

Genetic variations can alter protein function, with some mutations boosting activity or introducing new functions (gain of function), while others diminish or eliminate function (loss of function). These changes can have significant implications for human health and the treatment of disease.

This Perspective reviews large-scale genomics and longitudinal phenomics efforts and the insights they can provide into wellness. The authors describe their vision for the transformation of the current health care from disease-oriented to data-driven, wellness-oriented and personalized population health.

The targeted integration of large DNA payloads into primary human T cells can be efficiently achieved non-virally by leveraging Cas9-based editing and the DNA-repair pathway homology-mediated end joining.

Brain transplant is not a reality for humans or for any living organism. But there are human research experiments in which transplanted brain cells are used to help treat several diseases that affect the brain. So far, there are very few results and measured outcomes of brain cell transplant, but the concept of transplanting brain tissue has shown some promise in preliminary studies.

If you are interested in having a brain cell transplant procedure, you can talk to your healthcare provider and look for a university or research center where brain cell transplant procedures are being done. These procedures tend to be part of research studies, so you will likely need to enroll in a research study if you want to have this type of treatment.

The brain is composed of many different regions and cells. Neurons in the brain have dedicated functions, and they do not typically heal when they are damaged. Parkinson’s disease, stroke, multiple sclerosis (MS), epilepsy, Alzheimer’s disease, and head trauma are among the conditions for which brain cell transplant has been used for humans in an experimental setting.

Newly approved CRISPR treatment can change a person’s “blueprint.”

Scientists have discovered that bacteria can form memory-like mechanisms, informing strategies that lead to dangerous infections in humans. These strategies include antibiotic resistance and the formation…