Lifeboat Foundation

The capacity to regulate the biodistribution of therapeutics is a highly desired feature that can limit the side effects of many drugs. In a new study in Scientific Reports, Noah Joseph, and a team of biotechnology and nanoscience scientists in Israel, describe a nanoscale agent developed from a coupled polymer-DNA origami hybrid capable of exhibiting stability in serum and slow diffusion through tissues.

By coupling to fragments of polyethylene glycol through polyamine electrostatic interactions, the team noted marked stability of the agents in vivo, where more than 90% of the constituents maintained structural integrity for five days after subcutaneous injection.

The findings highlight the polymer-DNA hybrid nanostructures as viable pharmacological agents that can enter mainstream technologies, including their use as monoclonal antibodies for drug activity.

Buckle up, because we’re entering the era of thinking machines that make humans look like chattering chimps! But don’t worry about polishing your resume to impress our future robot overlords just yet. The experts are wildly divided on when superintelligent AI will actually arrive. It’s like we’re staring at an AI time machine without knowing if it will teleport us to 2 years from now or 2 decades into the future!

In one corner, we have Mustafa Suleyman from Inflection AI. He says take a chill pill, we’ve got at least 10–20 more years before the AI apocalypse. But hang on…his company just whipped up the world’s 2nd biggest AI supercomputer! It’s cruising with 3X the horsepower of GPT-4, the chatbot with reading skills rivaling a university professor. So something tells me Suleyman’s timeline is slower than your grandma driving without her glasses.

Continue reading “The AI Time Machine: When Will Superintelligence Arrive?” »

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Is the Matrix really real? And if so, which pill would David Chalmers take?

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Discover the power of gene editing, including the widely used CRISPR-Cas9 technology, and explore major publicly traded CRISPR companies.

One of ray kurzweils wonder machines are already here self assembled nanobots called foglet machines. This could allow for future avatars that people could pilot for daily life.

Colloidal magnetic nanoparticles are candidates for application in biology, medicine and nanomanufac-turing. Understanding how these particles interact collectively in fluids, especially how they assemble and aggregate under external magnetic fields, is critical for high quality, safe, and reliable deployment of these particles. Here, by applying magnetic forces that vary strongly over the same length scale as the colloidal stabilizing force and then varying this colloidal repulsion, we can trigger self-assembly of these nanoparticles into parallel line patterns on the surface of a disk drive medium. Localized within nanometers of the medium surface, this effect is strongly dependent on the ionic properties of the colloidal fluid but at a level too small to cause bulk colloidal aggregation.

5th BigBrain Workshop 2021
22 September 2021 — Applications.
Chair: Kathleen Rockland.

The Unique Cytoarchitecture and Wiring of The Default Mode Network.
Casey Paquola.

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An amazing graph theoretic analysis of the C. elegans neuropeptide connectome!

Neuromodulation by peptides is essential for brain function. By comprehensively mapping neuropeptide signaling in the nematode C. elegans, Ripoll-Sánchez et al. define a dense wireless network whose organization differs in important ways from wired brain circuits. This network is a prototype for understanding neuropeptide signaling networks in larger brains.

Weaving piezoelectric polymers into nanofibers reveals a surprising pathway to boost stem cell growth naturally, without external power.

Our bodies are a complex tapestry of cells, woven into tissues and organs, like bones, muscle, and skin. All these cells begin as blank slates called stem cells, which are directed to become all the unique cell types in the body by a myriad of genetic and environmental cues.

To harness the biomedical potential of stem cells, researchers have long sought ways to untangle these factors and find a recipe to efficiently grow any desired cell type. Now, expertise from textile research is helping create a new platform to achieve this goal.

Investigators from the laboratory of Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, have discovered a new repeat gene cluster sequence that is exclusively expressed in humans and non-human primates.

The discovery, detailed in a study published in Science Advances, is a breakthrough for human genome biology and has wide-ranging implications for future research in transcriptional regulation, human evolution, and the study of repetitive DNA sequences, according to the authors.

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