Lifeboat Foundation

Read about the goal to detect and treat cancers at early stages, enable effective treatments, and reduce cancer cases and deaths.

Mini-brains that work and grow like their full-size counterparts could offer an alternative to animal testing, and advance the quest for personalized medicine.

Phage viruses that target bacteria have been known for a century but there are still no clinical trials – though compassionate treatment of patients with pseudomonas shows huge success.

Summary: Neuroscientists delved into the mechanisms behind true and false memories. Their study reveals that electrical signals in the hippocampus can differentiate between the imminent recall of authentic versus fabricated memories.

By monitoring neural activity in epilepsy patients, the team identified distinct patterns ahead of a correct or false recall. These findings not only offer insights into memory retrieval but may also pave the way for novel therapeutic interventions for disorders like PTSD.

But are you ready to explain this complex disease in terms that your child can understand?

Keep It Simple for Young Children Use language that is appropriate for your child’s age to describe what happens when asthma flares-up. Try to avoid medical terminology and details that will confuse a young child. Stick to the basic information at first. This includes making your child aware of what triggers symptoms and giving very basic understanding of what happens to cause the symptoms. Visit Just for Kids for story books, games and puzzles that explain asthma in terms your child can understand.

Medication management is not necessarily an issue with young children, as it is your responsibility as a caregiver to make certain you give your child medication as prescribed. Set a routine so it’s easy to remember when these medications should be taken. Practice with a nebulizer, peak flow meter and spacer so that your child understands how each device helps manage asthma.

150 YEARS MAXIMUM BIOLOGICAL AGE — “We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.”

We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of aging process, henceforth referred to as dynamic organism state index (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

P.O. Fedichev is a shareholder of Gero LLC. A.Gudkov is a member of Gero LLC Advisory Board. T.V. Pyrkov, K. Avchaciov, A.E. Tarkhov, L. Menshikov, and P.O. Fedichev are employees of Gero LLC.

In the biomedical field, optical characterization of cells and tissues is a valuable tool for understanding physiological mechanisms. Current biomedical optical imaging techniques include fluorescence imaging [1], confocal microscopy [2], optical coherence tomography [3], two-photon microscopy [4], near-infrared spectroscopy [5], and diffuse optical tomography [6]. These techniques have significantly advanced biomedical technology and are widely used for both preclinical and clinical purposes. However, the strong optical scattering within turbid biological tissues fundamentally limits the imaging depth of these pure optical imaging techniques to no deeper than the optical ballistic depth ( 1 mm). Thus, their observation depth is superficial and other imaging modalities are needed to explore deeper layers of biological tissue [7].

Photoacoustic imaging (PAI), a promising biomedical technique, achieves superior imaging depths by forming images from optically-derived acoustic signals, which inherently attenuate less than optical signals in biological tissue [8, 9, 10]. PAI is based on the photoacoustic (PA) effect, in which energy is converted from light to acoustic waves via thermoelastic expansion [11,12,13,14,15,16]. To generate PA waves, a laser beam with a typical pulse width of a few nanoseconds illuminates the target tissue. The optical chromophores in biological tissue absorb the light energy and then release the energy soon after. The energy release can can occur as either light energy with a slightly shifted wavelength or as thermal energy that causes thermoelastic expansion. In PAI, the rapidly alternating thermoelastic expansion and contraction caused by pulsed light illumination generates vibrations in tissue that propagate as acoustic waves called PA waves. The generated PA waves can be detected by conventional ultrasound (US) transducers for image generation. Because PAI and ultrasound imaging (USI) share the same signal reception and image reconstruction principle, the two modalities are technically fully compatible and can be implemented in a single US imaging platform accompanied with pulse laser source [17,18,19,20,21]. Since PAI can capture the photochemical properties of the target site, combining PAI with USI can provide both chemical and structural information about a target tissue.

One distinctive advantage of PAI is that its resolution and imaging depth can be adjusted to suit a specific target area. The resolution of PA signals depends on both the optical focus of the excitation laser and the acoustic focus of the receiving US transducer [22], so images with tuned spatial resolutions and imaging depths can be achieved by modifying the system configuration [23]. PAI’s wide applications to date have included nanoscale surface and organelle imaging [24,25,26,27,28], microscale cellular imaging [29,30,31,32], macroscale small animal imaging [33,34,35], and clinical human imaging [36,37,38].

A new study finds artificial intelligence could help predict pancreatic cancer. Dr. Chris Sander, one of the co-authors of the study, joined CBS News to talk about the findings.

#news #ai #cancer.

Continue reading “AI could help predict pancreatic cancer, study finds” »

X-ray technology plays a vital role in medicine and scientific research, providing non-invasive medical imaging and insight into materials. Recent advancements in X-ray technology enable brighter, more intense beams and imaging of increasingly intricate systems in real-world conditions, like the insides of operating batteries.

To support these advancements, scientists are working to develop X-ray detector materials that can withstand bright, high-energy X-rays—especially those from large X-ray synchrotrons—while maintaining sensitivity and cost-effectiveness.

A team of scientists at the U.S. Department of Energy’s (DOE) Argonne National Laboratory and their colleagues have demonstrated exceptional performance of a new material for detecting high energy X-ray scattering patterns. With excellent endurance under ultra-high X-ray flux and relatively low cost, the detector material may find wide application in synchrotron-based X-ray research.