Lifeboat Foundation

The human gut microbiome is known to have a significant influence on many aspects of our health. Usually, when people think of the gut microbiome, they think of the many bacterial species that live there. Other organisms like viruses and fungi are also members of the human gut microbiome that have been getting more research attention. Now, scientists have identified a unicellular organism called Blastocystis, a type of protist with many subtypes that are also a part of the human gut microbiome. The research has shown that different subtypes of Blastocystis can lead to beneficial health impacts while others are detrimental. The findings have been reported in The EMBO Journal.

People in Singapore have been found with a rare Blastocystis subtype called ST7, which is often isolated from patients with diarrhea. Blastocystis ST7 seems to cause gut disease, although the mechanisms that underlie this pathology have been unclear.

There is evidence that some form of conscious experience is present by birth, and perhaps even in late pregnancy, an international team of researchers from Trinity College Dublin and colleagues in Australia, Germany and the U.S. has found.

The findings, published today in Trends in Cognitive Science, have important clinical, ethical and potentially legal implications, according to the authors.

In the study, titled “Consciousness in the cradle: on the emergence of infant experience,” the researchers argue that by birth the infant’s developing brain is capable of conscious experiences that can make a lasting imprint on their developing sense of self and understanding of their environment.

It might be possible to stop or slow the autoimmune progression of multiple sclerosis (MS) by deleting a receptor in the central nervous system, according to a study published today in the journal Science Immunology.

Using mouse models, researchers reported that deleting a receptor that selectively targets a specific type of T cells stopped them from entering the central nervous system while allowing other T cells to penetrate and protect the body from pathogens.

With the vehicle, Springer and her team want to bridge the gap between patients at home and healthcare providers in established healthcare systems.

“What we really are trying to do is build bridges and linkages,” Springer said.

A first-of-its-kind fully mobile pharmacy may soon be coming near you. The “Integrated Mobile Opioid Treatment and Infectious disease cOordinated care in your Neighbourhood,” also known as “InMOTION,” was started by Sandra Springer, a professor of medicine at the Yale School of Medicine, and her team, with the goal of bringing a working pharmacy to people’s homes and enhancing access to health care for residents of Connecticut.

Continue reading “The state’s first fully mobile pharmacy is coming to Connecticut” »

This might be a game-changing tool for accelerating scientific research.

An international group of scientists has begun work on developing a ChatGPT-like tool to accelerate scientific discovery. In recent years, scientists have been leveraging artificial intelligence (AI) for the purpose of advancing scientific research and exploration.

AI’s capability to analyze extensive datasets, simulate complex phenomena, and aid researchers in modeling and comprehending intricate systems has the potential to be a game-changer in various fields, including but not limited to medicine, astronomy, climate science, and materials research.

Continue reading “ChatGPT-like tool to advance scientific studies is in the making” »

As the efficiency of non-viral delivery methods improves, they have the potential to make cell and gene therapy development faster and more cost-effective, as well as mitigating adverse effects.

Salk Institute researchers, as part of a larger collaboration with research teams around the world, analyzed more than half a million brain cells from three human brains to assemble an atlas of hundreds of cell types that make up a human brain in unprecedented detail.

The research, published in a special issue of the journal Science on October 13, 2023, is the first time that techniques to identify brain cell subtypes originally developed and applied in mice have been applied to human brains.

“These papers represent the first tests of whether these approaches can work in human brain samples, and we were excited at just how well they translated,” says Professor Joseph Ecker, director of Salk’s Genomic Analysis Laboratory and a Howard Hughes Medical Institute investigator. “This is really the beginning of a new era in brain science, where we will be able to better understand how brains develop, age, and are affected by disease.”

A quarter-century ago, researchers discovered that adults, not just developing infants, can generate new brain cells, a process called neurogenesis. But it’s still not clear what role these new neurons play in health or disease.

In a new mouse study, Columbia University researchers found that neurogenesis in adults is critical for maintaining brain circuits that support working memory across the lifespan and chronic loss of adult neurogenesis causes progressive memory loss, like that seen in age-related cognitive decline and Alzheimer’s disease in humans.

The study, “Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging,” was published in July in the journal Molecular Psychiatry.

A study by researchers in the laboratory of Dr. Huda Zoghbi, distinguished service professor at Baylor College of Medicine and director of the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital, has discovered that diminished memory recall in Rett syndrome mice can be restored by activating specific inhibitory cells in the hippocampus. The findings are published in the current edition of Neuron.

Rett syndrome is a neurodevelopmental disorder characterized by loss of acquired cognitive, motor, language and social skills after the first year of life as well as profound learning and memory impairments. In particular, contextual memories, those that encode an event and the circumstances in which the event was experienced, are diminished in mouse models of Rett syndrome. Previous research has suggested that diminished contextual memories result from disruptions in the finely tuned balance between excitatory and inhibitory synaptic inputs that constantly bombard hippocampal neurons.

Zoghbi’s team hypothesized that disruptions in this balance may alter the size and composition of ensembles of hippocampal neurons needed to encode a contextual memory. Using a miniature microscope, they directly monitored these ensembles as mice recalled a fearful experience. They found that Rett mice have larger and more correlated ensembles of neurons than wild-type mice, suggesting that hippocampal pyramidal neurons are not receiving enough inhibition in Rett mice.