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About 10% of people living with myositis—a rare inflammatory disease in which the immune system attacks healthy muscle cells—also are at risk for developing cancer. Determining which patients need screening and close follow-up is difficult.

“We screen a lot of people aggressively, and possibly unnecessarily,” says rheumatologist Christopher Mecoli, M.D., M.H.S., director of research operations and physician lead for the Myositis Precision Medicine Center of Excellence. This can lead to potential harms for patients such as radiation exposure, anxiety and false-positive test results that indicate a person has cancer when they actually do not.

The chatbot’s reasoning was “at times medically implausible or inconsistent, which can lead to misinformation or incorrect diagnosis, with significant implications,” the report noted.

The scientists also admitted some shortcomings with the research. The sample size was small, with 30 cases examined. In addition, only relatively simple cases were looked at, with patients presenting a single primary complaint.

It was not clear how well the chatbot would fare with more complex cases. “The efficacy of ChatGPT in providing multiple distinct diagnoses for patients with complex or rare diseases remains unverified.”

The idea that genetic modification can improve humanity isn’t new, but it has taken some interesting turns within the scientific community over the past few years. One of the most notable comes from the mind of He Jiankui, a Chinese scientist whose gene editing of human babies led to infamy and a prison sentence. Now, He, known as JK to friends, thinks that gene-edited humans could be the future of our species.

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Mixing and matching various strands of DNA can create versatile biological computer circuits that can take the square roots of numbers or solve quadratic equations.

By Karmela Padavic-Callaghan

Generic single-stranded oligonucleotides used as a uniform transmission signal can reliably integrate large-scale DNA integrated circuits with minimal leakage and high fidelity for general-purpose computing.

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Similarly, individuals who were diagnosed with diabetes at the age of 40 years died ten years earlier, and those diagnosed at the age of 50 died six years earlier than their healthy counterparts.

A robust association was established between earlier age of diabetes diagnosis and deaths due to vascular and non-neoplastic conditions. Common vascular diseases include stroke and myocardial infarction, while non-neoplastic conditions include neurological, respiratory, and infectious diseases.

The association between life expectancy and diabetes was marginally greater in women than in men. Compared to older adults, higher hazard ratios for mortality were associated with earlier age of diabetes detection.

In a recent study published in JAMA, researchers investigated whether accelerometer-assessed sedentary behavior was associated with incident dementia.

The global population is engaging in more sedentary-type activities such as sitting while using the computer, watching television, and driving. Studies have reported associations between sedentary behavior and cardiometabolic diseases and related mortality; however, its relationship with new-onset dementia is not clear.

A clinical trial led by NCI has resulted in FDA approval of the immunotherapy drug atezolizumab (Tecentriq) to treat advanced alveolar soft part sarcoma.