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Category: biotech/medical – Page 453

Dr. Ryan Potts, Ph.D. — VP and Head, Induced Proximity Platform, Amgen — Any Target, Every Time

Leading The Next Wave Of Innovation In Drug Discovery, To Modulate Any Target, Every Time — Dr. P. Ryan Potts, Ph.D., VP and Head, Induced Proximity Platform, Amgen.

Dr. Ryan Potts, Ph.D. is Vice President and Head, Induced Proximity Platform at Amgen (https://www.amgen.com/science/researc…) which is focused on novel ways to bring two or more molecules in close proximity to each other to tackle drug targets that are currently considered “undruggable.” He also leads Amgen’s Research \& Development Postdoctoral Fellows Program (https://www.amgen.com/science/scienti…).

Dr. Potts obtained his B.S. in Biology from the University of North Carolina and his Ph.D. in Cell and Molecular Biology from UT Southwestern in 2007. In 2008 he was awarded the Sara and Frank McKnight junior faculty position at UT Southwestern Medical Center. During this time his lab focused on answering a long-standing question in cancer biology regarding the cellular function of cancer-testis antigen (CTAs) proteins. In 2011 he was appointed Assistant Professor in the Departments of Physiology, Pharmacology, and Biochemistry at UT Southwestern Medical Center. His lab’s work defined a function for the enigmatic MAGE gene (Melanoma Antigen Gene) family in protein regulation through ubiquitination.

In 2016 Dr. Potts lab moved to St. Jude Children’s Research Hospital where he was an Associate Member in the Department of Cell and Molecular Biology. There his lab continued to work on CTAs, with a focus on elucidating the biochemical, cellular, physiological and pathological functions of the MAGE gene family.

In 2020 Dr. Potts moved to Amgen, Inc. in Thousand Oaks, California to build a new department called the Induced Proximity Platform (IPP).

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‘Then I Am Myself the World’ ponders what it means to be conscious

Then I Am Myself the World Christof Koch Basic Books, $30

The human brain is the most complex information integrator known in the universe. With 86 billion neurons and 100 trillion connections between them, the brain gives us our rich subjective experiences and our capacity for free will — our consciousness.

Despite being a universal human phenomenon, consciousness is notoriously difficult to describe, and scientists still debate how it arises. In Then I Am Myself the World, neuroscientist Christof Koch offers the latest entry into the long list of books attempting to demystify the origins of our inner lives (SN: 1/5/22). While the topic can be a head-scratcher, Koch’s adept use of analogies and entertaining anecdotes — complete with his own near-death experience and psychedelic drug trips — make the book a compelling and surprisingly light read.

How the stressed-out brain can weaken the immune system

Stress sensitive neural circuits change the gut microbiome and the duodenal glands.

Precision mapping of a gut-brain circuit w/ functional impact.

Glands in the small intestine (Brunner’s) have GLP-1 receptors, are stress-sensitive, connect to the brain via the vagal nerve, modulate bacterial…

Stress leads to disarray of the gut microbiome, which in turn causes inflammation and a drop in the body’s ability to fend off infection.

Glimpse into the nanoworld: Microscope reveals tiniest cell processes

What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers from the Universities of Göttingen and Oxford, in collaboration with the University Medical Center Göttingen (UMG), have succeeded in developing a microscope with resolutions better than five nanometers (five billionths of a meter). This is roughly equivalent to the width of a hair split into 10,000 strands. Their new method was published in Nature Photonics.

Northrop Grumman spacecraft hitches ride on SpaceX rocket for NASA resupply mission

The Cygnus spacecraft is filled with nearly 8,200 pounds of supplies, hardware and other critical materials for dozens of scientific and research experiments, according to NASA.

That includes tests for water recovery technology and supplies needed for a process to produce blood and immune stem cells in microgravity. Also included in the payload are materials to study the effects of spaceflight on engineered liver tissue and microorganism DNA, NASA said.