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Ultrathin optical elements known as meta-optics can reduce the tip length of endoscopes, which is one of the limiting factors of these medical devices. That’s the latest finding from researchers at the University of Washington, who used an inverse design approach to downsize the tip length by a third. They also demonstrate that the endoscope can capture video in real time over the full visible spectrum, something that has proved difficult with previous approaches.

Endoscopy involves inserting a long, flexible tube (consisting of a camera and a light guide) into the body to obtain images of internal tissues. In existing devices, the tube is tipped with a rigid optical component, the length of which is a fundamental limitation to the device being able to travel through small convoluted ducts such as arteries.

In principle, this problem can be solved by making an endoscope from just a single optical fibre or a bundle of fibres, but the snag here is that some of the light travelling down the fibres is scattered by defects and gets distorted beyond recognition. It cannot therefore be reconstructed to obtain an accurate image. Such devices are also limited to short working distances.

Georgia Tech researchers have transformed a standard BBQ lighter into a delivery system that uses an electric spark to boost DNA vaccines — and it could help increase global access to a cheap, powerful new vaccine technology.

mRNA vs. DNA vaccines: DNA vaccines deliver a bit of genetic code that tells cells in the body to make a protein from a specific virus or bacteria. That triggers the immune system to create antibodies against that protein that will protect you if you’re ever infected by that particular pathogen.

This is exactly how mRNA vaccines work, too, and just like mRNA vaccines, DNA-based shots are relatively cheap to produce and easy to change to make new vaccines — but the way mRNA and DNA vaccines get their genetic instructions into cells is different.

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Low-calorie, intermittent-fasting, and ketogenic diets all can lower the amount of blood glucose available to fuel cancer cells.

Eukaryotes organize cellular contents into membrane-bound organelles and membrane-less condensates, for example, protein aggregates. An unsolved question is why the ubiquitously distributed proteins throughout the cytosol give rise to spatially localized protein aggregates on the organellar surface, like mitochondria. We report that the mitochondrial import receptor Tom70 is involved in the localized condensation of protein aggregates in budding yeast and human cells. This is because misfolded cytosolic proteins do not autonomously aggregate in vivo; instead, they are recruited to the condensation sites initiated by Tom70’s substrates (nascent mitochondrial proteins) on the organellar membrane using multivalent hydrophobic interactions. Knocking out Tom70 partially impairs, while overexpressing Tom70 increases the formation and association between cytosolic protein aggregates and mitochondria. In addition, ectopic targeting Tom70 and its substrates to the vacuole surface is able to redirect the localized aggregation from mitochondria to the vacuolar surface. Although other redundant mechanisms may exist, this nascent mitochondrial proteins-based initiation of protein aggregation likely explains the localized condensation of otherwise ubiquitously distributed molecules on the mitochondria. Disrupting the mitochondrial association of aggregates impairs their asymmetric retention during mitosis and reduces the mitochondrial import of misfolded proteins, suggesting a proteostasis role of the organelle-condensate interactions.

Photonic systems are quickly gaining traction in many emerging applications, including optical communications, lidar sensing, and medical imaging. However, the widespread adoption of photonics in future engineering solutions hinges on the cost of manufacturing photodetectors, which, in turn, largely depends on the kind of semiconductor utilized for the purpose.

Traditionally, silicon (Si) has been the most prevalent semiconductor in the electronics industry, so much so that most of the industry has matured around this material. Unfortunately, Si has a relatively weak light absorption coefficient in the near-infrared (NIR) spectrum compared to those of other semiconductors such as gallium arsenide (GaAs).

Because of this, GaAs and related alloys thrive in photonic applications, but are incompatible with the traditional complementary metal-oxide-semiconductor (CMOS) processes used in the production of most electronics. This leads to a drastic increase in their manufacturing costs.

More people than ever before—828 million, according to the most recent estimates—do not know where their next meal will come from. Yet we are producing more food than ever, with cereal grain production at an all-time high. How did we get so far off track in ending hunger and how do we get back on course?

Food crises are complex, and the temptation is to fix the symptom, rather than identifying the cause. COVID-19, conflict, and climate change are among the most frequently cited causes of the current food price crisis, but the underlying systemic issue remains: We need to radically transform the way we produce and consume food.

A more stable, equitable, and sustainable food system would connect the world’s 600 million farms with its 8 billion consumers, and capitalize on the ability to both feed the hungry while mitigating greenhouse gas emissions and rapidly adapting to a changing climate. We must act now, together, and decisively, or risk more crises in the future. Five critical actions are set out below.

A researcher is undertaking several parallel approaches to understand the microenvironment’s role in pancreatic cancer.