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Category: biotech/medical – Page 494

Nanotechnology: How Nanomaterials Are Changing the Game

A series of advances in materials and design have enabled manufacturers to work at scales smaller than a billionth of a size to create devices and objects of nanoscopic dimensions. This is nanotechnology, which, although relatively new, produces materials and technologies already used in mass production.

The European Commission defines nano as any material that is at least 50% composed of particles between one and one hundred nanometers in size (i.e. one billionth of a meter, or one-millionth of a millimeter). Nanomaterials differ from conventional materials because of their unique properties such as higher electrical conductivity and mechanical strength, sensor technologies, and biomedical applications, and because they can create coatings that make surfaces more hydrophobic or self-cleaning.

The widespread use of nanotechnology is relatively new. Since 2000, nanomaterials have been used industrially as new research and experimental designs have made their effectiveness in different sectors clear. For example, in the health field, nanotechnology helps to reduce diagnostic errors and to develop nanobots (microscale robots) to repair and replace intercellular structures, or repair DNA molecules; in the chemical sector, it facilitates coating devices with nanoparticles to improve their smoothness and heat resistance; in manufacturing, materials developed with nanotechnology enhance the performance of the final product by improving heat resistance, strength, durability, and electrical conductivity.

Breakthrough in nanoscale force measurement opens doors to unprecedented biological insights

Groundbreaking research has revealed a new way to measure incredibly minute forces at the nanoscale in water, pushing the boundaries of what scientists know about the microscopic world.

The significant nanotechnology advance was achieved by researchers from Beihang University in China with RMIT University and other leading institutions including the Australian National University and University of Technology Sydney (Nature Photonics, “Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy”).

The new technique, involving a super-resolved photonic force microscope (SRPFM), is capable of detecting forces in water as small as 108.2 attonewtons – a scale so minute that it compares to measuring the weight of a virus.

Scientists discover new behavior of membranes that could lead to unprecedented separations

Imagine a close basketball game that comes down to the final shot. The probability of the ball going through the hoop might be fairly low, but it would dramatically increase if the player were afforded the opportunity to shoot it over and over.

A similar idea is at play in the scientific field of membrane separations, a key process central to industries that include everything from biotechnology to petrochemicals to water treatment to food and beverage.

“Separations lie at the heart of so many of the products we use in our everyday lives,” said Seth Darling, head of the Advanced Materials for Energy Water Systems (AMEWS) Center at the U.S. Department of Energy’s (DOE) Argonne National Laboratory. “Membranes are the key to achieving efficient separations.”

Hard Yet Stretchable: Scientists Create “Unbreakable” New Material

Researchers have created a new class of materials called “glassy gels” that are as hard as glassy polymers, but – if you apply enough force – can stretch up to five times their original length, rather than breaking. A key thing that distinguishes glassy gels is that they are more than 50% liquid, which makes them more efficient conductors of electricity than common plastics that have comparable physical characteristics. Credit: Meixiang Wang, NC State University.

Researchers have developed a new class of materials known as glassy gels, which combine the hardness of glassy polymers with the stretchability of gels.

These materials maintain over 50% liquid content, enhancing their elasticity and adhesive properties. The fabrication process involves mixing polymer precursors with an ionic liquid and curing with ultraviolet light, allowing for easy production and potential for widespread application in industries like electronics and medical devices.

Subcutaneous Versus IV Nivolumab for Kidney Cancer

For people with advanced kidney cancer, an injectable form of nivolumab (Opdivo) is a suitable alternative to the original intravenous form, early results from a clinical trial have shown. Experts say the injectable form makes the treatment quicker and easier for patients to receive.

As a result, “patients’ treatment experience will be significantly improved,” said the trial’s leader, Saby George, M.D., of Roswell Park Comprehensive Cancer Center in Buffalo, NY.

The clinical trial involved nearly 500 people with advanced or metastatic kidney cancer. All participants were randomly assigned to receive a new form of nivolumab that is given as injection under the skin (subcutaneous) or the original form, which is given through a vein (an intravenous infusion, or IV).

Five-drug combination targets aggressive B-cell lymphomas

Researchers at the National Institutes of Health (NIH) have developed a non-chemotherapy treatment regimen that is achieving full remissions for some people with aggressive B-cell lymphoma that has come back or is no longer responding to standard treatments. The five-drug combination targets multiple molecular pathways that diffuse large B-cell lymphoma (DLBCL) tumors use to survive.

In a clinical trial at NIH’s National Cancer Institute (NCI), researchers tested the combination of venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (called ViPOR) in 50 patients with DLBCL, the most common type of lymphoma. The treatment shrank tumors substantially in 26 of 48 (54%) evaluable patients, with 18 (38%) of those patients’ tumors disappearing entirely, known as a complete response. At two years, 36% of all patients were alive and 34% were free of disease. These benefits were seen mainly in people with two specific subtypes of DLBCL.

The findings were published June 20, 2024, in the New England Journal of Medicine.

How hot is too hot for the human body? Study identifies upper limit

An article from last year that’s still relevant.

2023 article

Researchers investigated when the body starts exerting more energy to keep itself cool at high temperatures.

They found that this upper-temperature limit lies between 40℃ (104F) and 50℃ (122F) when the human body stops functioning…

New research finds the human body may stop functioning optimally when outside temperatures reach beyond certain temperatures.