The actor Bruce Willis was diagnosed with aphasia in April 2022—updated in February 2023 to frontotemporal dementia (FTD). Now, a major advancement is helping develop new treatments for some people with motor neuron diseases, including FTD and ALS, possibly including a nasal spray that could help prevent the genetic disease.
I dunno if anyone has seen this. As a former Linux user, I’ve been an Nvidia fan for a long time and now they’ve gone on from games and Bitcoin mining. Sorry if this is a double post. I’m on my way out the door for my mom’s Dr appointment. I always worry I’ll double post by accident.
NVIDIA’s Jensen Huang just announced a set of revolutionary new Artificial Intelligence Models and Partnerships at GTC 2023. NVIDIA has always been one of, if not the most important company in the AI Industry by creating the most powerful AI hardware to date. Among them the A100 and future H100 GPU’s which are powering GPT-4 from OpenAI, Midjourney and everyone else. This gives them a lot of power to jump into the AI race themselves and allows them to surpass and beat the currently best AI models from Large Language Models and Image Generation with software like Omniverse and Hardware like the DGX H100 Supercomputer and Grace CPU’s.
–
TIMESTAMPS:
00:00 NVIDIA enters the AI Industry.
01:43 GTC 2023 Announcements.
04:48 How NVIDIA Beat Every Competitor at AI
07:40 Running High End AI Locally.
10:20 What is NVIDIA’s Future?
13:05 Accelerating Future.
–
Technology is improving at an almost exponential rate. Robots are learning to walk & think, Brain Computer Interfaces are becoming commonplace, new Biotechnology is allowing for age reversal and Artificial Intelligence is starting to surpass humans in many areas. Follow FutureNET to always be up to date on what is happening in the world of Futuristic Technology and Documentaries about humanities past achievements.
–
#nvidia #ai #gtc
Macromolecular machines acting on genes are at the core of life’s fundamental processes, including DNA replication and repair, gene transcription and regulation, chromatin packaging, RNA splicing, and genome editing. Here, we report the increasing role of computational biophysics in characterizing the mechanisms of “machines on genes”, focusing on innovative applications of computational methods and their integration with structural and biophysical experiments. We showcase how state-of-the-art computational methods, including classical and ab initio molecular dynamics to enhanced sampling techniques, and coarse-grained approaches are used for understanding and exploring gene machines for real-world applications.
A recently patented genome editing tool called PASTE holds genuine promise for expanding the universe of treatable genetic diseases. The approach combines elements of CRISPR and prime editing with a pair of enzymes designed to enable the integration of large segments of DNA without incurring double-stranded DNA breaks.
U.S. Patent No. 11,572,556, assigned to MIT, covers systems, methods, and compositions for programmable addition via site-specific targeting elements (PASTE). The patent describes site-specific integration of a nucleic acid into a genome, using a CRISPR–Cas9 nickase fused to a reverse transcriptase (RT) and a serine integrase. These enzymes target specific genome sequences known as attachment sites, binding to them before integrating their DNA payload.
PASTE can insert DNA fragments as large as 50,000 base pairs, which puts it on a different plane compared to other genome editing tools such as prime editing.
The collateral activity of the CRISPR/RfxCas13D system in mammalian cells is explored using spike-in RNA-seq and reporter assays.
Vow, an Australian cultivated food company that creates meat in a laboratory setting from animal cells, says that it has used advanced molecular engineering to resurrect the woolly mammoth in meatball form, by combining original mammoth DNA with fragments of an African elephant’s DNA.
James Ryall, Vow’s chief science officer, said that the company first identified the mammoth myoglobin, a protein that is key to giving meat its color and taste, and then used publicly available data to identify the DNA sequence in mammoths.
Australian company Vow says it has used advanced molecular engineering to resurrect the woolly mammoth in meatball form.
Continue reading “Cultured meat firm resurrects woolly mammoth in lab-grown meatball” »
Caltech engineers have made a significant breakthrough in the field of nano-and micro-architected materials by creating a novel material composed of multiple interconnected microscale knots.
Compared to structurally identical but unknotted materials, the presence of knots in this new material significantly enhances its toughness by enabling it to absorb more energy and deform more before returning to its original shape without any damage. These new knotted materials may find applications in biomedicine as well as in aerospace applications due to their durability, possible biocompatibility, and extreme deformability.
“The capability to overcome the general trade-off between material deformability and tensile toughness [the ability to be stretched without breaking] offers new ways to design devices that are extremely flexible, durable, and can operate in extreme conditions,” says former Caltech graduate student Widianto P. Moestopo (MS ‘19, Ph.D. ’22), now at Lawrence Livermore National Laboratory. Moestopo is the lead author of a paper on the nanoscale.
Nita Farahany, professor of law and philosophy at Duke University, has written a new book, The Battle for Your Brain: Defending the Right to Think Freely in the Age of Neurotechnology (Macmillan), which explores how our lives may be impacted by the use of brain-computer interfaces and neural monitoring devices.
Farahany argues that the development and use of neurotech presents a challenge to our current understanding of human rights. Devices designed to measure, record, and influence our mental processes—used by us or on us—may infringe on our rights to mental privacy, freedom of thought, and mental self-determination. She calls this collection of freedoms the right to cognitive liberty. IEEE Spectrum spoke with Farahany recently about the future and present of neurotech and how to weigh its promises—enhanced capabilities, for instance, including bionics and prosthetics and even a third arm —against its potential to interfere with people’s mental sovereignty.
Author, Nita FarahanyMerritt Chesson.
😗
Eukaryotes generate the energy for survival through cellular respiration in mitochondria by a process known as the oxidative phosphorylation. In this process, nutrients and oxygen are converted into a chemical form of energy: ATP. This is achieved with a proton gradient built up by the electron transport chain inside mitochondria.
Follow our step-by-step video guide for growing cerebral organoids, or brain organoids, from human pluripotent stem cells (hPSCs). We’ll walk you through embryoid body formation, induction, expansion, and organoid maturation.
0:35 — Embryoid Body Formation.
2:57 — Induction.
4:07 — Expansion.
6:42 — Organoid Maturation.
Continue reading “How to Grow Cerebral Organoids from Human Pluripotent Stem Cells” »
