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Category: biotech/medical – Page 63

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

Researchers identified three types of zombie skin cells; only one gets worse with age. Researchers have identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions – an advance that could equip scientists with the ability to target and kill the harmful types while leaving the helpful ones intact.

Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation and promoting diseases while also helping the immune system to heal wounds.

New findings may explain why: Not all senescent skin cells are the same. They were published today in the journal Science Advances.

Coming Soon to Apple Devices: Brain Control Accessibility Features

Apple is making progress on a standard for brain implant devices that can help people with disabilities control devices such as iPhones with their thoughts. As reported in The Wall Street Journal, Apple has plans to release that standard to other developers later this year.

The company has partnered with Synchron, which has been working with other companies, including Amazon, on ways to make devices more accessible. Synchron makes an implant called a Stentrode that is implanted in a vein on the brain’s motor cortex. Once implanted, the Stentrode can read brain signals and translate that to movement on devices including iPhones, iPads and Apple’s Vision Pro VR headset.

As we saw last year, a patient with ALS testing the Synchron technology was able to navigate menus in the Vision Pro device and use it to experience the Swiss Alps in VR. The technology could become more widely available to people with paralysis. The company has a community portal for those interested in learning about future tests.

Which Epigenetic Clock Is Best For Evaluating Death Risk?

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Sugar-coated nanotherapy dramatically improves neuron survival in Alzheimer’s model

Scientists at Northwestern University have developed a new approach that directly combats the progression of neurodegenerative diseases like Alzheimer’s disease and amyotrophic lateral sclerosis (ALS).

In these devastating illnesses, proteins misfold and clump together around brain cells, which ultimately leads to cell death. The innovative new treatment effectively traps the proteins before they can aggregate into the toxic structures capable of penetrating neurons. The trapped proteins then harmlessly degrade in the body.

The “clean-up” strategy significantly boosted the survival of lab-grown human neurons under stress from disease-causing proteins.

Scientists reveal crystal structure of protein that allows viruses to infect cells in human airway

New research by scientists at the University of Toronto and the Structural Genomics Consortium has deepened our understanding of how viruses like the flu, common cold, and COVID-19 get into cells in human airways.

Using the Canadian Light Source at the University of Saskatchewan, the researchers identified for the first time the crystal structures of a human protein (TMPRSS11D) that viruses use as a doorway into our body. The study is published in the journal Nature Communications.

Understanding how viruses use our proteins to gain entry into our cells will help researchers develop better ways to stop infections in their tracks.

How the tiny microbes in your mouth could be putting your health at risk

Current dental implants can work well, but they’re not perfect. They don’t attach to bones and gums in the same way that real teeth do. And around 20% of people who get implants end up developing an infection called peri-implantitis, which can lead to bone loss.

It is all down to the microbes that grow on them. There’s a complex community of microbes living in our mouths, and disruptions can lead to infection. But these organisms don’t just affect our mouths; they also seem to be linked to a growing number of disorders that can affect our bodies and brains. If you’re curious, read on.

The oral microbiome, as it is now called, was first discovered in 1670 by Antonie van Leeuwenhoek, a self-taught Dutch microbiologist. “I didn’t clean my teeth for three days and then took the material that had lodged in small amounts on the gums above my front teeth … I found a few living animalcules,” he wrote in a letter to the Royal Society at the time.

Designing enzymes from scratch: New workflow paves way for more powerful and environmentally benign chemistry

Researchers at UC Santa Barbara, UCSF and the University of Pittsburgh have developed a new workflow for designing enzymes from scratch, paving the way toward more efficient, powerful and environmentally benign chemistry. The new method allows designers to combine a variety of desirable properties into new-to-nature catalysts for an array of applications, from drug development to materials design.

This research is published in the journal Science, and is the result of a collaborative effort among the DeGrado lab at UCSF, the Yang lab at UCSB and the Liu lab at the University of Pittsburgh.

“If people could design very efficient enzymes from scratch, you could solve many important problems,” said UCSB chemistry professor Yang Yang, a senior author on the paper.