Lifeboat Foundation

On December 18, 2019, Wuhan Central Hospital admitted a patient with symptoms common for the winter flu season: a 65-year-old man with fever and pneumonia. AI Fen, director of the emergency department, oversaw a typical treatment plan, including antibiotics and anti-influenza drugs.

Six days later, the patient was still sick, and AI was puzzled, according to news reports and a detailed reconstruction of this period by evolutionary biologist Michael Worobey. The respiratory department decided to try to identify the guilty pathogen by reading its genetic code, a process called sequencing. They rinsed part of the patient’s lungs with saline, collected the liquid, and sent the sample to a biotech company. On December 27, the hospital got the results: The man had contracted a new coronavirus closely related to the one that caused the SARS outbreak that began 17 years before.

The US Department of Energy has assessed that the Covid-19 pandemic most likely came from a laboratory leak in China, according to a newly updated classified intelligence report.

Two sources said that the Department of Energy assessed in the intelligence report that it had “low confidence” the Covid-19 virus accidentally escaped from a lab in Wuhan.

Intelligence agencies can make assessments with either low, medium or high confidence. A low confidence assessment generally means that the information obtained is not reliable enough or too fragmented to make a more definitive analytic judgment or that there is not enough information available to draw a more robust conclusion.

Aging is a complex process, a river fed by several tributaries connected by countless interweaving streams. Its direction is set inexorably towards infirmity, or so it would first appear. Daunting as navigation may seem, their interrelatedness should inspire hope instead of fear.

Aging is undeniably the root of the most common and costly noncommunicable diseases in the developed world, as well as a predisposing factor to severe or fatal reactions to infectious ones. Whatever can be done to slow, halt, or reverse its course holds inestimable economic and humanitarian value (Lee, 2017).

The hallmarks of aging were assembled to broadly conceptualize what lies behind phenomena as seemingly unrelated as gray hair, wrinkles, heart disease, cognitive decline, and cancer. They serve as explanations for why everything from our joints to our eyesight steadily give out over time.

As chatbot responses begin to proliferate throughout the Internet, they will, in turn, impact future machine learning algorithms that mine the Internet for information, thus perpetuating and amplifying the impact of the current programming biases evident in ChatGPT.

ChatGPT is admittedly a work in progress, but how the issues of censorship and offense ultimately play out will be important. The last thing anyone should want in the future is a medical diagnostic chatbot that refrains from providing a true diagnosis that may cause pain or anxiety to the receiver. Providing information guaranteed not to disturb is a sure way to squash knowledge and progress. It is also a clear example of the fallacy of attempting to input “universal human values” into AI systems, because one can bet that the choice of which values to input will be subjective.

If the future of AI follows the current trend apparent in ChatGPT, a more dangerous, dystopic machine-based future might not be the one portrayed in the Terminator films but, rather, a future populated by AI versions of Fahrenheit 451 firemen.

Nature has an extraordinary knack for producing composite materials that are simultaneously light and strong, porous and rigid — like mollusk shells or bone. But producing such materials in a lab or factory — particularly using environmentally friendly materials and processes — is extremely challenging.

Researchers in the Soft Materials Laboratory in the School of Engineering turned to nature for a solution. They have pioneered a 3D printable ink that contains Sporosarcina pasteurii: a bacterium which, when exposed to a urea-containing solution, triggers a mineralization process that produces calcium carbonate (CaCO3). The upshot is that the researchers can use their ink — dubbed BactoInk — to 3D-print virtually any shape, which will then gradually mineralize over the course of a few days.

-This would be good for coral reefs.

Continue reading “3D printing with bacteria-loaded ink produces bone-like composites” »

Normal body temperature can vary from individual to individual. However, despite this variation, the average basal body temperature of humans has mysteriously dropped since the 1860s. A recent study points to the gut microbiome as a possible contributor to regulating body temperature, both in healthy individuals and during life-threatening infections.

The study, conducted by a team of researchers led by Robert Dickson, M.D., at the University of Michigan Medical School, utilized health records from patients admitted to the hospital with sepsis and conducted experiments on mice to investigate the relationship between the gut bacteria composition, temperature changes, and health outcomes.

Sepsis, the body’s response to a life-threatening infection, can cause drastic changes in body temperature, the trajectory of which is linked to mortality. Previous work has demonstrated that hospitalized patients with sepsis vary widely in their temperature responses, and this variation predicts their survival.

A new study suggests that we may be able to prevent chronic inflammation in multiple sclerosis (MS) patients in a totally new way, by manipulating their gut microbiomes — the unique collection of microbes that live in our digestive tracts and play an important role in our health.

“We are approaching the search for multiple sclerosis therapeutics from a new direction,” said lead researcher Andrea Merchak from the University of Virginia (UVA).

Chronic inflammation: The immune system fights infections and heals injuries by sending inflammatory cells to the site of the problem. This process, inflammation, can cause pain, swelling, or other side effects, but ultimately, it’s for the greater good.

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Continue reading “Epigenetic Test #4: What’s My Biological Age?” »

The pros and cons of moonlighting—taking up an extra job in addition to full-time employment—are hotly debated. But in biology, moonlighting is not uncommon, as individual proteins often perform multiple functions. For many years, scientists knew that the Unusual Floral Organ (UFO) protein seems to do some moonlighting.

Based on the protein’s structure, its role in plants is thought to target proteins for destruction. But it also works with the Leafy (LFY) protein to aid flower formation. A team of scientists from France has now shed light on how this protein performs two roles.