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Altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate, according to a new study led by Cedars-Sinai and the University of California, San Francisco (UCSF).

The findings, to be published today (January 13) in the peer-reviewed journal Cell Stem Cell, may assist in the development of new drugs that can manipulate this process to slow or stop cancer from growing and spreading, and enable regeneration in the context of other diseases.

Ophir Klein, MD, PhD, executive director of Cedars-Sinai Guerin Children’s and the senior author of the study, said the findings underscore the body’s need to produce just the right amount of new cells.

Many of us have seen microscopic images of neurons in the brain — each neuron appearing as a glowing cell in a vast sea of blackness. This image is misleading: Neurons don’t exist in isolation. In the human brain, some 86 billion neurons form 100 trillion connections to each other — numbers that, ironically, are far too large for the human brain to fathom.

Wei-Chung Allen Lee, Harvard Medical School associate professor of neurology at Boston Children’s Hospital, is working in a new field of neuroscience called connectomics, which aims to comprehensively map connections between neurons in the brain.

Last year, Verve Therapeutics started the first human trial of a CRISPR treatment that could benefit most people—a signal that gene editing may be ready to go mainstream.

The University of Singapore has invented a VR Glove that allows you to feel objects in the metaverse! The technology includes pressurized fingertips and restricted motion that mimics the real-life sensation of picking up objects. The goal is to assist medical professionals to practice in Virtual Reality (but we can see how these would make for some pretty incredible immersive gameplay). Production will begin over the next few years.

The VR glove is an important advancement in wearable tech, as it is a fully untethered haptic system. With this super fast feedback loop, the glove encounters the metaverse in what is essentially real-time. So, that means minimal to no lag for users. Additionally, the gloves are lighter and more affordable than the gloves that are currently on the market. This makes The National University of Singapore’s HaptGlove all the more impressive as a piece of wearable tech.

The glove was developed by The National University of Singapore for use with trainees at the National University Health System. Specifically, users will be able to use the technology to grasp surgical devices or check the pulse of a patient. Furthermore, the haptic system inside the glove should resemble the feeling of an object on your fingertips, providing real-time feedback. This is an important moment for the medical field that could have serious impact, as VR becomes a testing ground for future health tech. It’s interesting to note this development alongside other trends, like the push towards Web5.

Past neuroscience research consistently found a link between deviations from the “normal” iron metabolism, also known as iron dysregulation, and different neurodegenerative diseases, including Parkinson’s disease (PD) and Multiple Sclerosis (MS). Specifically, brain regions associated with these diseases have been found to be often populated by microglia (i.e., resident immune cells) packed with Iron.

While the association between iron dysregulation and neurodegenerative diseases is well documented, the ways in which iron accumulation affects the physiology of microglia and neurodegeneration are yet to be fully grasped. Researchers at global health care company Sanofi have recently carried out a study aimed at filling this gap in the literature, by better understanding how microglia respond to iron.

“For years it has been known that iron accumulates in affected brain regions in PD, MS and other neurodegenerative diseases,” Timothy Hammond, one of the researchers who carried out the study, told MedicalXpress. “This is something we can see in patients using MRI imaging, where it has been shown that iron levels increase over the course of the disease. We also had our own data from progressive MS patients showing iron dysregulation in brain microglia, the resident immune cells of the brain.”

High-energy, short-pulse laser sources exist only in a limited number of colors. Researchers in the 1960s found that a liquid-filled cell, which had inadvertently been placed inside a laser’s cavity, shifted the laser’s wavelength. Now a team of scientists from Brookhaven National Laboratory (BNL), New York, show that synthetic, room-temperature liquid salts can also serve as effective laser-color-tuning media [1]. The finding could lead to a simple and energy-efficient tool for creating lasers with desired colors for medical and scientific applications.

In the 1960’s liquid technique, when a photon “hits” a liquid molecule, the photon loses energy, exiting the medium with less energy—and thus a different color—than it entered (see Focus: Holey Fibers Shed New Light). The BNL team reasoned that a salt solution could interact with photons in the same way while offering a high density of energy-swapping sites compared to either a gas or a standard liquid. The vast array of available artificial salts could also make it possible to precisely tune the energy loss caused by the salt–photon interaction, giving increased color control.

The researchers assembled their converter setup from a pulsed green laser and a 63-cm-long cell filled with a salt solution. Passing the laser through the cell, they observed that the light turned orange. The researchers measured a high color-conversion efficiency of the photons, which they attribute to the large interaction cross sections of the salt molecules and to the reduction of other forms of scattering that can inhibit wavelength conversion. The group is currently designing liquids to turn this and other lasers to myriad colors.

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier—the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain’s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

“There is no cure yet for many devastating brain disorders,” says Shaoqin “Sarah” Gong, UW-Madison professor of ophthalmology and visual sciences and biomedical engineering and researcher at the Wisconsin Institute for Discovery. “Innovative brain-targeted delivery strategies may change that by enabling noninvasive, safe and efficient delivery of CRISPR genome editors that could, in turn, lead to genome-editing therapies for these diseases.”

CRISPR is a molecular toolkit for editing genes (for example, to correct mutations that may cause disease), but the toolkit is only useful if it can get through security to the job site. The blood-brain barrier is a membrane that selectively controls access to the brain, screening out toxins and pathogens that may be present in the bloodstream. Unfortunately, the barrier bars some beneficial treatments, like certain vaccines and gene therapy packages, from reaching their targets because in lumps them in with hostile invaders.

A study conducted in Brazil and reported in an article published in Molecular Psychiatry suggests that schizophrenia may be associated with alterations in the vascularization of certain brain regions. Researchers at the State University of Campinas (UNICAMP), D’Or Research and Education Institute (IDOR) and the Federal University of Rio de Janeiro (UFRJ) found a link between astrocytes (central nervous system cells) from patients with schizophrenia and formation of narrow blood vessels.

Schizophrenia is a severe multifactorial mental health disorder affecting around 1% of the world population. Common symptoms include loss of contact with reality (psychosis), hallucinations (hearing voices, for example), delusions or delirium, disorganized motor behavior, loss of motivation and cognitive impairment.

In the study, the researchers focused on the role of astrocytes in development of the disease. These glial cells are housekeepers of the central nervous system and important to its defense. They are the central elements of the neurovascular units that integrate neural circuitry with local blood flow and provide neurons with metabolic support.

Michael Levin is an American developmental and synthetic biologist at Tufts University. His research interests include: bioelectrical signals by which cells communicate to serve the dynamic anatomical needs of the organism during development, regeneration, and cancer suppression; basal cognition and intelligence in diverse unconventional substrates; and top-down control of form and function across scales in biology.

Join us as we discuss.
- Bioelectricity.
- Regeneration.
- The future in medicine.
- The act of free will and more.

Continue reading “Rekindi #29 — Bioelectricity, Regeneration, Cancer Suppression & Xenobots — with Michael Levin” »