Lifeboat Foundation

Summary: Researchers have successfully created a synthetic version of a small molecule found in a recently discovered sea sponge that appears to have therapeutic benefits for Parkinson’s disease.

Source: UCLA

Organic chemists at UCLA have created the first synthetic version of a molecule recently discovered in a sea sponge that may have therapeutic benefits for Parkinson’s disease and similar disorders. The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells.

José Cordeiro, PhD, talking about his international bestseller “The Death of Death” during the coming DLD Tel Aviv Innovation Festival in Israel. Top news at i24 news discussing about aging as the “mother” of all chronic diseases!

José Cordeiro is an international fellow of the World Academy of Art and Science, vicechair of HumanityPlus, director of The Millennium Project, founding faculty at Singularity University in NASA Research Park, Silicon Valley, and former director of the Club of Rome (Venezuela Chapter), the World Transhumanist Association and the Extropy Institute.

Continue reading “The Death of Death during the coming #DLD Tel Aviv Innovation Festival in Israel. Top news at #i24” »

A new technological development by Tel Aviv University has made it possible for a robot to smell using a biological sensor. The sensor sends electrical signals as a response to the presence of a nearby odor, which the robot can detect and interpret.

In this new study, the researchers successfully connected the biological sensor to an electronic system and, using a machine learning algorithm, were able to identify odors with a level of sensitivity 10,000 times higher than that of a commonly used electronic device. The researchers believe that in light of the success of their research, this technology may also be used in the future to identify explosives, drugs, diseases, and more.

Continue reading “A robot able to ‘smell’ using a biological sensor” »

The orbitofrontal cortex (OFC) is a region in the frontal lobe of the brain known to be involved in decision-making and information processing. The lateral part of this brain region, known as the lOFC, has been identified as a particularly salient region for the creation of so-called “cognitive maps.”

Cognitive maps are mental representations of the world that are believed to guide human behavior. While past studies have linked the lOFC to the brain’s use of these maps, it is still unclear whether it creates these maps or merely deploys them when necessary.

Researchers at the National Institute on Drug Abuse in Baltimore and the Max Planck Institute for Biological Cybernetics have recently carried out a study exploring these two hypotheses, with the hope of better understanding the functions of the lOFC. Their findings, published in Nature Neuroscience, suggest that the lateral OFC is directly involved in the writing of cognitive maps.

Science_Hightech — operanewsapp.

Chronic pancreatitis, a painful, debilitating condition, often requires major surgery to remove all or part of the pancreas. Few large studies have evaluated how these patients fare five years or more after their operations. The largest study to date of patients who have had surgery for chronic pancreatitis with follow-up of six years or longer has found that about two-thirds survive after 10 years. However, more than one-fourth of these patients were still using opioids daily for pain.

The study, presented at the Southern Surgical Association 134^th annual meeting in December in Palm Beach, Florida, has been published online as an “article in press” in the Journal of the American College of Surgeons (JACS).

“After surgical intervention, we, as surgeons, expect that we return these patients back to their normal lives,” said lead study author Gregory C. Wilson, MD, an assistant professor of surgery at the University of Cincinnati College of Medicine. “In this study, we have long-term follow-up examining survival and cause of death in these patients well after that surgical period, and what we see is that survival continues to decline even five years out from surgery.”

Recent experiments conducted in Boston labs have shown reverse aging results among mice and could show similar results in people.

The combined experiments — which were conducted during a span of 13 years — published Thursday (January 12) in the scientific journal Cell reported that old, blind mice regained eyesight, developed smarter brains and built healthier muscle and kidney tissue, challenging the theory that DNA was the only cause of aging, as it proved that chemical and structural changes to chromatin played a factor without altering genetic code.

The research showed that a breakdown in epigenetic information caused the mice to age and the restoration of the epigenome reversed aging effects.

Virus-enveloping macromolecular shells or tilings can prevent viruses from entering cells. Here, we describe the design and assembly of a cone-shaped DNA origami higher-order assembly that can engulf and tile the surface of pleomorphic virus samples larger than 100 nm. We determine the structures of subunits and of complete cone assemblies using cryoelectron microscopy (cryo-EM) and establish stabilization treatments to enable usage in in vivo conditions. We use the cones exemplarily to engulf influenza A virus particles and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), chikungunya, and Zika virus-like particles. Depending on the relative dimensions of cone to virus particles, multiple virus particles may be trapped per single cone, and multiple cones can also tile and adapt to the surface of aspherical virus particles. The cone assemblies form with high yields, require little purification, and are amenable for mass production, which is a key requirement for future real-world uses including as a potential antiviral agent.

The concept of emergence is controversial to some — for example Eliezer Yudkowski, who favors reductionism, wrote a critique at Less Wrong (see link below). Do reductionists often dismiss emergence?

Ben formalized emergence in his book ‘The Evolving Mind’ as patterns that appear when you put two or more things together that are not there in any of the individual parts.
Book — ‘The Evolving Mind’: http://www.goertzel.org/books/mind/contents.html http://www.amazon.com/Evolving-Futures-General-Evolution-Stu…atfound-20

Continue reading “Ben Goertzel — Emergence, Reduction & Artificial Intelligence” »