Metastasis, the deadliest and most notorious hallmark of the disease, gives cancer the ability to spread throughout the body, often overwhelming immune defenses and even the…
28 to 34% lifespan increase in mice. I wonder if there would be side effects as a recent study showed Rapamycin and Metformin canceled each other’s side effects.
In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1].
Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity of aging, researchers have to deal with the biological heterogeneity of animals even within the same species and research reproducibility issues due to different experimental designs and approaches.
Continue reading “Combination of Rapamycin and Acarbose Extends Lifespan” »
So early to bed early to rise does not necessarily make a person healthy wealthy and wise.
In a recent study, scientists found early sleeping had a 70% higher risk of developing dementia.
Sleep may impact both physical and mental health and has been linked to various health conditions such as heart disease, stroke, dementia, depression, and obesity.
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Continue reading “Improve Lung Function, Reduce Blood Pressure, Slow Brain Aging?” »
The users can effectively manipulate the prosthetics exactly like they would with an intact limb.
University of Utah researchers have developed the most advanced AI-powered prosthetics “ever created,” prompting Ottobock, the world’s largest prosthetic manufacturer, to collaborate with them to launch the project globally.
Continue reading “Utah Bionic Leg: The most advanced AI-powered prosthetics ‘ever created’” »
While CommonSpirit declined to share specifics, a person familiar with its remediation efforts confirmed to NBC News that it had sustained a ransomware attack.
CommonSpirit, which has more than 140 hospitals in the U.S., also declined to share information on how many of its facilities were experiencing delays. Multiple hospitals, however, including CHI Memorial Hospital in Tennessee, some St. Luke’s hospitals in Texas, and Virginia Mason Franciscan Health in Seattle all have announced they were affected.
Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia are key players in the brain immune system and provide structural and nutritional support for neurons, they are intimately involved in multiple neurological disorders. Recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), Epilepsy, Parkinson’s disease (PD), Alzheimer’s disease (AD), and frontotemporal dementia (FTD). While there is compelling evidence for glial modulation of synaptic formation and regulation that affect neuronal signal processing and activity, in this manuscript we will review recent findings on neuronal activity that affect glial function, specifically during neurodegenerative disorders. We will discuss the nature of each glial malfunction, its specificity to each disorder, overall contribution to the disease progression and assess its potential as a future therapeutic target.
Glia are non-neuronal cells of the nervous system which do not generate electrical impulses yet communicate via other means such as calcium signals. Due to their lack of electrical activity, it was previously assumed that glial cells primarily functioned as “nerve-glue” (Virchow, 1860) and performed house-keeping functions for neurons; however, this concept has shifted due to recent findings showing glia are key components in many neuronal functions that go far beyond housekeeping (Araque et al., 1999; Buskila et al., 2019a).
Glial cells are categorized into two main groups; macroglia, which includes astrocytes, oligodendrocytes, NG2-glia and ependymal cells, and microglia which are the resident phagocytes of the central nervous system (CNS). Each population of glial cells is specialized for a particular function in the central or peripheral nervous system (García-Cabezas et al., 2016), and normal brain function depends on the interplay between neurons and the various types of glial cells. In this review, we will focus on astrocytes and microglia.
This technique involves having participants place their finger over the camera and flash of a smartphone, which uses a deep-learning algorithm to decipher the blood oxygen levels from the blood flow patterns in the resulting video.
Conditions like asthma or COVID-19 make it harder for bodies to absorb oxygen from the lungs. This leads to oxygen saturation percentages dropping to 90% or below, indicating that medical attention is needed.
In a clinic, doctors monitor oxygen saturation using pulse oximeters — those clips you put over your fingertip or ear. But monitoring oxygen saturation at home multiple times a day could help patients keep an eye on COVID symptoms, for example.
Dr. Amy Proal, Ph.D. serves as President & CEO of the PolyBio Research Foundation (https://polybio.org/), and Chief Scientific Officer of the Long Covid Research Initiative (LCRI — https://lc19.org/).
In her work with PolyBio Research Foundation and the LCRI, Dr. Proal conceptualizes and coordinates large-scale collaborative research projects among research teams studying infection-associated chronic conditions such as Long Covid, Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Long Lyme.
Dr. Sarita A. Mohanty, MD, MPH, MBA (https://www.thescanfoundation.org/about/board-of-directors/sarita-a-mohanty/), serves as the President and Chief Executive Officer of The SCAN Foundation, one of the largest foundations in the United States focused on improving the quality of health and life for older adults. Its mission is to advance a coordinated and easily navigated system of high-quality services for older adults that preserve dignity and independence.
The SCAN Foundation was created as an independent charitable organization in April 2008 through a $205 Million one-time contribution from the not-for-profit SCAN Health Plan, a not-for-profit, Medicare Advantage based in Long Beach, California.
