Lifeboat Foundation

But the technology for using bridge RNA in genome editing is still in the early stages. Hsu’s team has demonstrated this system only in bacteria, though Hsu says he is optimistic that efforts to adapt the approach to work in mammalian cells will succeed. Chen says this system’s efficiency may not be as good as CRISPR’s is now but that improvements will come with time.

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer’s disease. Leveraging single-cell Merfish spatial transcriptomics technology, the team was able to profile the effects of the mutation across multiple cortical and subcortical brain regions, offering first-of-their-kind insights at the single-cell level.

The study, published in Molecular Psychiatry, compared the brains of normal mice and special mouse models that undergo changes like those in humans with Alzheimer’s.

Findings revealed that the TREM2 mutation led to divergent patterns of beta-amyloid plaque accumulation in various parts of the brain involved in higher-level functions such as memory, reasoning and speech. It also affected certain cell types and their gene expression near the plaques.

With the first CRISPR–Cas9 gene therapy now approved, scientists are turning to newer editing technologies to produce safer, faster and better treatments for genetic diseases.

The higher cost of owning an electric versus a gas-powered vehicle is a sticking point for many would-be buyers of EVs. Now, the price of a key EV component is falling, raising hopes that automakers could close the gap as they grapple with waning demand.

Batteries make up about one-third to one-fourth of the cost of producing an electric vehicle, according to Goldman Sachs analysts. The firm predicts the global average cost to automakers for batteries in 2024 will average about $115 per kilowatt hours, about 23% lower than last year. Prices are expected fall another 20% in 2025.

Tesla CEO Elon Musk (TSLA) recently noted costs have come down for lithium-ion cells used in EV batteries, a big reversal from the “massive spike” during the pandemic when car manufacturers put in “giant, giant orders.”

Elon Musk says his startup Neuralink has implanted a brain chip into a second patient and plans to perform another eight trials later this year.

Almost half the electrodes are working… for now.

DNA contains foundational information needed to sustain life. Understanding how this information is stored and organized has been one of the greatest scientific challenges of the last century.

With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome.

Chromosomes are threadlike structures composed entirely of DNA that reside in the cells of all living things. Each one of these biological databanks contains a wealth of genetic information that scientists can use to glean insights into the history and evolution of life on Earth. Normally, the remains of dead creatures degrade over time, causing DNA to fragment. Most ancient animal DNA discovered to date has been incomplete, often comprised of fewer than 100 base pairs out of the billions that once made up the full sequence of the organism.

However, the 52,000-year-old skin sample at the heart of this research was taken from behind the ear of a mammoth discovered in Northern Siberia in 2018. An intensive analysis of the sample revealed the presence of complete fossil chromosomes. These chromosomes, each measuring billionths of a meter in length, had seemingly been frozen in a glass-like state for tens of thousands of years. Knowing the shape of an organism’s chromosomes can help researchers to assemble entire DNA sequences of extinct creatures, a task previously deemed nearly impossible due to DNA degradation over time.

“This is a new type of fossil, and its scale dwarfs that of individual ancient DNA fragments — a million times more sequence,” explained Erez Lieberman Aiden, a corresponding author on the study and director of the Center for Genome Architecture at the Baylor College of Medicine.

(THE CONVERSATION) Racism steals time from people’s lives – possibly because of the space it occupies in the mind.

Question Is racial discrimination associated with brain connectivity, and are alterations in deep brain functional connectivity associated with accelerated epigenetic aging?

Findings In this cohort study of 90 Black women in the US, higher self-reported racial discrimination was associated with greater resting-state functional connectivity (RSFC) between the locus coeruleus (LC) and precuneus. Significant indirect effects were observed for the association between racial discrimination frequency and DNA methylation age acceleration.

Continue reading “Racial Discrimination, Neural Connectivity, and Epigenetic Aging in Black Women” »

A Perseid is one whose path, if traced backward across the sky, intersects a spot between the constellations Perseus and Cassiopeia. Other “sporadic” meteors traveling in random directions occur once every 5 or 10 minutes. Two much weaker showers are also active at this time of the year, the Delta Aquarids and Kappa Cygnids.

You’ll need no experience to watch the Perseids. Just find a spot with a wide-open sky view and no late-night lights nearby. Bundle up warmly (it can sometimes get chilly even on summer nights), lie back on a ground pad or in a sleeping bag or even better, on a reclining lawn chair, and watch the stars. Also cover exposed parts of your body with mosquito repellent so you won’t get bit.

Be patient, and give your eyes sufficient time to dark adapt. The direction to watch is not necessarily toward Perseus but wherever your sky is darkest, probably straight up.