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Category: biotech/medical – Page 878

Bowhead whales may have a cancer-defying superpower: DNA repair

Hints from the bowhead whale genome published nearly a decade ago predicted that the mammals may use this alternate strategy (SN: 1/6/15). “But you need actual experiments to actually validate those predictions,” Tollis says.

In the lab, study coauthor Vera Gorbunova at the University of Rochester in New York and her colleagues ran an assortment of experiments on cells harvested from bowhead whale tissue, as well as on cells from humans, cows and mice.

The whale cells were both efficient and accurate at repairing double-strand breaks in DNA, damage that severs both strands of the DNA double helix. Whale repair restored broken DNA to like-new condition more often than cells from other mammals, the team found. In those animals, mends to the genome tended to be sloppier, like a poorly patched pair of jeans. The team also identified two proteins in bowhead whale cells, CIRBP and RPA2, that are part of the DNA repair crew.

These little piggies helped their neighbors, but why? New research design may help shed light

Pigs are generally considered to have high intelligence, and new research shows that they may also be empathic to other members of their social groups, helping them during instances of need. But is this behavior truly unselfish, or is it driven by goal-specific motivations?

To investigate, researchers from the Research Institute for Farm Animal Biology in Germany and Austria’s University of Veterinary Medicine Institute of Animal Welfare Science have studied helping behavior among social groups of domestic pigs. Their work, titled “Spontaneous helping in pigs is mediated by helper’s social attention and distress signals of individuals in need,” is published in Proceedings of the Royal Society B.

In the wild, animals will often help members of their social groups in times of distress, defending them against predators or releasing them from traps, snares, or other types of confinement. There is no general consensus over whether such helping behavior is truly empathic, or whether it might be driven by a more selfish motivation.

Cleveland Clinic Study Shows Deep Brain Stimulation Encouraging for Stroke Patients

Click image for animation of DBS for post-stroke rehabilitation

A first-in-human trial of deep brain stimulation (DBS) for post-stroke rehabilitation patients by Cleveland Clinic researchers has shown that using DBS to target the dentate nucleus – which regulates fine-control of voluntary movements, cognition, language, and sensory functions in the brain – is safe and feasible.

The EDEN trial (Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke) also shows that the majority of participants (nine out of 12) demonstrated improvements in both motor impairment and function. Importantly, the study found that participants with at least minimal preservation of distal motor function at enrollment showed gains that almost tripled their initial scores.

Researchers find risk of premature birth 50% higher in mothers with poor mental health

New work led by researchers at the University of Exeter, King’s College London, the London School of Hygiene and Tropical Medicine and the University of Liverpool has found that women who had at least one contact with mental health services in the seven years prior to their pregnancy were at increased risk of preterm birth.

The study, “Obstetric and neonatal outcomes in pregnant women with and without a history of specialist mental care: a national population-based cohort study using linked routinely collected data in England,” published in Lancet Psychiatry, analyzed data from more than two million , and found that one in 10 women who had used mental health services before their pregnancy had a , compared to one in 15 in those who had not.

Researchers also found that women who had used mental health services faced a higher risk of giving birth to a baby that was small for its gestational age, increasing from 65 per 1,000 births in women who had not used mental health services to 75 per 1,000 births in women who had.

Hand-held tube containing aluminum foil balls produces enough electricity to power LED array when shaken

A team of mechanical engineers from Chung-Ang University, Massachusetts General Hospital, LS Materials and Yonsei University has found that a hand-held cylinder containing crumpled aluminum foil balls is capable of producing enough electricity when shaken to light a small LED grid. In their paper published in the journal Advanced Science, the group describes other materials used in the cylinder and possible uses for such a device.

Prior research has shown that a wide variety of materials can be used to generate , and that some constructions can capture that . Researchers have suggested such devices could be useful as the power needs of personal electronics decrease. In this new effort, the researchers have looked to aluminum foil as a material for generating static electricity and capturing it to power an external device.

The device the team built is shaped as a with a cap on the top and bottom—about the size of a Pringle’s can. The tube was made using an acrylic substrate covered with a polytetrafluoroethylene layer. The caps, which serve as electrodes, were made of aluminum. The team then crumpled three wads of into balls and placed them inside the tube.

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Australian Researchers Create Technique for Engineering Blood Vessels Using Natural Tissue

Blood vessels form the transportation network within our bodies. They are streets where red and white blood cells drive. They are the delivery system to oxygenate our brain and other vital organs and muscles. There are other highways in our bodies such as our nervous and lymphatic systems, but blood vessels are the ones that are central to healthy heart function and keeping our brain supplied with oxygen. When blood vessels are compromised we can suffer a stroke, heart attack, aneurysm or die.

When usual causes of heart attacks are blocked coronary arteries. The coronary arteries supply blood and oxygen to the heart. When partially blocked people experience symptoms like angina. When blocked they can suffer a myocardial infarction, the fancy name for a heart attack.

Today, harvested blood vessel grafts from human donors or the patient are used for bypassing coronary blood vessel blockages. But researchers at the University of Melbourne believe that fabricated blood vessel tissue that can be shaped to any need would be an effective substitute for existing grafts. The team in its search for a graft alternative has combined a variety of materials and living tissue with a fabrication technique to create complex blood vessels that can serve multiple purposes.