Lifeboat Foundation

The technology is based on integrated circuits, which typically rely on silicon semiconductors in order to process information in a way that is similar to the role played by the brain in the human body.

The research team discovered that integrated circuits capable of performing computational tasks could be achieved using “nearly any material” around us.

“We have created the first example of an engineering material that can simultaneously sense, think and act upon mechanical stress, without requiring additional circuits to process such signals,” said Ryan Harne, an associate professor of mechanical engineering at Penn State.

Modulating Autophagy To Promote Healthspan — Dr. Ana Maria Cuervo, M.D., Ph.D., Albert Einstein College of Medicine.

Dr. Ana Maria Cuervo, M.D., Ph.D. (https://www.einsteinmed.edu/faculty/8784/ana-maria-cuervo/) is Co-Director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. She serves as a Professor in the Department of Developmental & Molecular Biology, and the Department of Medicine (Hepatology), and has the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases.

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Aging is a complex and inevitable process that affects all organisms – and it is associated with tissue dysfunction, susceptibility to various diseases, and death [1]. The development of strategies like cellular reprogramming for increasing the duration of healthy life and promoting healthy aging is difficult since the mechanism of aging is not understood clearly. Aging is known to be associated with several hallmarks of aging – such as epigenetic alterations, genomic instability, cellular senescence, telomere shortening, mitochondrial dysfunction and altered intercellular communication.

Aging can be divided into two major phases: healthy aging and pathological aging. Healthy aging is the phase where the accumulation of minor alterations takes place, but pathological aging is the phase where clinical diseases and disabilities predominate along with the impairment of physiological functions [2].

Longevity. Technology: Notions regarding cells undergoing a unidirectional differentiation process during development existed previously [3]. However, in recent years cellular reprogramming using transcription factors has emerged as an important strategy for the rejuvenation of aging cells, erasing markers of cell damage and restoring epigenetic markers. These transcription factors also known as Yamanaka factors include Oct4, Sox2, Klf4, and c-Myc (OSKM). They can convert terminally differentiated somatic cells into pluripotent stem cells which are capable of dividing into any cell type of the body and thus can improve the health and longevity of individuals.

A test that can detect hundreds of thousands of different fragments of DNA sequences, proteins or antibodies could be built onto a tiny silicon chip. Researchers say the technology could lead to devices for medical diagnostics or environmental monitoring.

Scientists have long sought to untangle the mystery of how aging links to increased risk of heart disease, a predominant killer of our time. It’s a tough problem: many biological aspects, spanning nature to nurture, can subtly influence heart health. To untangle the mystery, some experiments have lasted over half a century and scaled to hundreds of thousands of people.

The good news? We’ve got clues. With age, heart cells drastically change their function, eventually struggling to contract and release. A new study published in Nature Aging looked deep into genetic code to unravel why this happens.

Starting with a dozen volunteers spanning 0 to 82 years old, the team sequenced the entire genome of 56 heart muscle cells, or cardiomyocytes. The result is the first landscape painting of genetic changes in the aging heart. As we age, the heart gets hit with a double whammy at the DNA level. Cells’ genetic code physically breaks down, while their ability to repair DNA erodes.

A collection of photos of genetically unrelated look-alikes, along with DNA analysis, revealed that strong facial similarity is associated with shared genetic variants. The work appears August 23 in the journal Cell Reports.

“Our study provides a rare insight into human likeness by showing that people with extreme look-alike faces share common genotypes, whereas they are discordant at the epigenome and microbiome levels,” says senior author Manel Esteller of the Josep Carreras Leukemia Research Institute in Barcelona, Spain. “Genomics clusters them together, and the rest sets them apart.”

The number of people identified online as virtual twins or doubles who are genetically unrelated has increased due to the expansion of the World Wide Web and the possibility of exchanging pictures of humans across the planet. In the new study, Esteller and his team set out to characterize, on a molecular level, random human beings that objectively share facial features.

According to recent Baycrest research, adults without dementia risk factors like smoking, diabetes, or hearing loss had brain health comparable to that of those who are 10 to 20 years younger than them. According to the research, only one dementia risk factor can age a person’s cognition by up to three years.

“Our results suggest lifestyle factors may be more important than age in determining someone’s level of cognitive functioning. This is great news since there’s a lot you can do to modify these factors, such as managing diabetes, addressing hearing loss, and getting the support you need to quit smoking,” says Dr. Annalise LaPlume, Postdoctoral Fellow at Baycrest’s Rotman Research Institute (RRI) and the study’s lead author.

The research is one of the first to look at lifestyle risk factors for dementia across the entire lifespan.

Many heart problems, including tachycardia and fibrillation, mainly originate from imperfections in the way electric currents propagate through the heart. Unfortunately, it is difficult for doctors to study these imperfections. This is because measuring these currents involves highly invasive procedures and exposure to X-ray radiation.

Luckily, there are other options. For example, magnetocardiography (MCG) is a promising alternative approach to measuring heart currents indirectly. The technique involves sensing minute changes in the magnetic field near the heart caused by cardiac currents. This can be done in a completely contactless manner. To this end, various types of quantum sensors suitable for this purpose have been developed. However, their spatial resolution is limited to centimeter scales, which is not good enough to detect cardiac currents that propagate at millimeter scales. Furthermore, each of these sensors has a fair share of its practical limitations, such as size and operating temperature.

In a new study published today (August 23, 2022) in Communications Physics, a team of scientists developed a novel setup to perform MCG at higher resolutions. Their approach is based on a diamond quantum sensor comprising nitrogen vacancies, which act as special magnetic “centers” that are sensitive to the weak magnetic fields produced by heart currents. The researchers were led by Associate Professor Takayuki Iwasaki of Tokyo Institute of Technology (Tokyo Tech), Japan.

In recent years, roboticists have developed a wide variety of robotic systems with different body structures and capabilities. Most of these robots are either made of hard materials, such as metals, or soft materials, such as silicon and rubbery materials.

Researchers at Hong Kong University (HKU) and Lawrence Berkeley National Laboratory have recently created Aquabots, a new class of soft robots that are predominantly made of liquids. As most biological systems are predominantly made up of water or other aqueous solutions, the new robots, introduced in a paper published in ACS Nano, could have highly valuable biomedical and environmental applications.

“We have been engaged in the development of adaptive interfacial assemblies of materials at the oil-water and water-water interface using nanoparticles and polyelectrolytes,” Ho Cheung (Anderson) Shum, Thomas P. Russell, and Shipei Zhu told TechXplore via email. “Our idea was to assemble the materials that the interface and the assemblies lock in the shapes of the liquids. The shapes are dictated using external forces to generate arbitrary shapes or to use all-liquid 3D printing to be able to spatially organize the assemblies.”