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Sep 8, 2023

Exercise-induced hormone irisin may reduce Alzheimer’s disease plaque and tangle pathology in the brain

Posted by in categories: biotech/medical, health, neuroscience

Researchers who previously developed the first 3D human cell culture models of Alzheimer’s disease (AD) that displays two major hallmarks of the condition—the generation of amyloid beta deposits followed by tau tangles—have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

As reported in the journal Neuron, the Massachusetts General Hospital (MGH)–led team has uncovered promising results suggesting that irisin-based therapies might help combat AD.

Physical exercise has been shown to reduce deposits in various mouse models of AD, but the mechanisms involved have remained a mystery.

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