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Dec 7, 2023

HIV-1 reservoir size after neonatal antiretroviral therapy and the potential to evaluate antiretroviral-therapy-free remission (IMPAACT P1115): a phase 1/2 proof-of-concept study

Posted by in category: biotech/medical

Long-term data from a study implemented by the # NIH-funded International Maternal Pediatric Adolescent AIDS Clinical Trials Network showed very early antiretroviral therapy (ART) for infants who acquired HIV in utero enabled some infants to sustain viral suppression for more than two years.


Very early ART for in-utero HIV-1 can achieve sustained virological suppression in association with biomarkers indicating restricted HIV-1 reservoirs by age 2 years, which might enable potential ART-free remission.

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